Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling
出版年份 2021 全文链接
标题
Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling
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出版物
Frontiers in Pharmacology
Volume 12, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2021-07-15
DOI
10.3389/fphar.2021.667644
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- METTL14-regulated PI3K/Akt signaling pathway via PTEN affects HDAC5-mediated epithelial–mesenchymal transition of renal tubular cells in diabetic kidney disease
- (2021) Zhaoxia Xu et al. Cell Death & Disease
- Relevance of the Pyroptosis-Related Inflammasome Pathway in the Pathogenesis of Diabetic Kidney Disease
- (2021) Pan Liu et al. Frontiers in Immunology
- Crosstalk between PTEN/PI3K/Akt Signalling and DNA Damage in the Oocyte: Implications for Primordial Follicle Activation, Oocyte Quality and Ageing
- (2020) Mila Maidarti et al. Cells
- Overexpression of METTL3 attenuates high-glucose induced RPE cell pyroptosis by regulating miR-25-3p/PTEN/Akt signaling cascade through DGCR8
- (2020) Xu Zha et al. Aging-US
- Perspectives on the role of PTEN in diabetic nephropathy: an update
- (2020) Manoj Khokhar et al. CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
- Hypothermia protects neurons against ischemia/reperfusion-induced pyroptosis via m6A-mediated activation of PTEN and the PI3K/Akt/GSK-3β signaling pathway
- (2020) Meng-Yuan Diao et al. BRAIN RESEARCH BULLETIN
- Chemical constituents, clinical efficacy and molecular mechanisms of the ethanol extract of Abelmoschus manihot flowers in treatment of kidney diseases
- (2020) Nan Li et al. PHYTOTHERAPY RESEARCH
- Mechanisms of Herbal Nephroprotection in diabetes mellitus
- (2020) Dorin Dragoș et al. Journal of Diabetes Research
- Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy
- (2020) Qian Cheng et al. ACTA PHARMACOLOGICA SINICA
- Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice
- (2020) Fang Yang et al. BIOMEDICINE & PHARMACOTHERAPY
- Role of m6A RNA methylation in cardiovascular disease (Review)
- (2020) Yuhan Qin et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- New Insights into the Mechanisms of Pyroptosis and Implications for Diabetic Kidney Disease
- (2020) Jinwen Lin et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Total Flavones of Abelmoschus manihot Remodels Gut Microbiota and Inhibits Microinflammation in Chronic Renal Failure Progression by Targeting Autophagy-Mediated Macrophage Polarization
- (2020) Yue Tu et al. Frontiers in Pharmacology
- Epigenetics and epigenomics in diabetic kidney disease and metabolic memory
- (2019) Mitsuo Kato et al. Nature Reviews Nephrology
- Multifactorial functions of the inflammasome component NLRP3 in pathogenesis of chronic kidney diseases
- (2019) Shrikant R. Mulay KIDNEY INTERNATIONAL
- NOD-like receptors and inflammasomes: A review of their canonical and non-canonical signaling pathways
- (2019) Jaye M. Platnich et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Nε-carboxymethyl-lysine-induced PI3K/Akt signaling inhibition promotes foam cell apoptosis and atherosclerosis progression
- (2019) Zhongqun Wang et al. BIOMEDICINE & PHARMACOTHERAPY
- Application of Herbal Medicines with Heat-Clearing Property to Anti-Microinflammation in the Treatment of Diabetic Kidney Disease
- (2019) Jing Guo et al. Evidence-based Complementary and Alternative Medicine
- Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
- (2019) Humayun Sharif et al. NATURE
- The PTEN–PI3K Axis in Cancer
- (2019) Papa et al. Biomolecules
- Recent Insights on Inflammasomes, Gasdermin Pores, and Pyroptosis
- (2019) Nathalia M. de Vasconcelos et al. Cold Spring Harbor Perspectives in Biology
- NLRP3 inflammasome negatively regulates podocyte autophagy in diabetic nephropathy
- (2019) Yun Hou et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications
- (2019) Zi-Wei Yu et al. LIFE SCIENCES
- Glomerular podocytes in diabetic renal disease
- (2019) Paweł Podgórski et al. Advances in Clinical and Experimental Medicine
- Inhibition of Akt/mTOR/p70S6K Signaling Activity With Huangkui Capsule Alleviates the Early Glomerular Pathological Changes in Diabetic Nephropathy
- (2018) Wei Wu et al. Frontiers in Pharmacology
- PI3k/AKT signaling pathway: Erythropoiesis and beyond
- (2018) Mahjoobeh Jafari et al. JOURNAL OF CELLULAR PHYSIOLOGY
- RNA m6A modification and its function in diseases
- (2018) Jiyu Tong et al. Frontiers of Medicine
- Huangkui capsule alleviates renal tubular epithelial-mesenchymal transition in diabetic nephropathy via inhibiting NLRP3 inflammasome activation and TLR4/NF-κB signaling
- (2018) Wenbei Han et al. PHYTOMEDICINE
- Molecular mechanisms involved in podocyte EMT and concomitant diabetic kidney diseases: an update
- (2017) Qidi Ying et al. RENAL FAILURE
- Treatment of chronic kidney disease using a traditional Chinese medicine,Flos Abelmoschus manihot(Linnaeus) Medicus (Malvaceae)
- (2016) Yizhi Chen et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Notoginsenoside R1 ameliorates podocyte injury in rats with diabetic nephropathy by activating the PI3K/Akt signaling pathway
- (2016) Guodong Huang et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Recent Advances in Traditional Chinese Medicine for Kidney Disease
- (2015) Yifei Zhong et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- PTEN Inhibits High Glucose-Induced Phenotypic Transition in Podocytes
- (2015) Lingling Xing et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Huangkui capsule attenuates renal fibrosis in diabetic nephropathy rats through regulating oxidative stress and p38MAPK/Akt pathways, compared to α-lipoic acid
- (2015) Zhi-Min Mao et al. JOURNAL OF ETHNOPHARMACOLOGY
- NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component
- (2015) Hexin Shi et al. NATURE IMMUNOLOGY
- Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
- (2015) Annette Ives et al. Nature Communications
- Efficacy and Safety of Abelmoschus manihot for Primary Glomerular Disease: A Prospective, Multicenter Randomized Controlled Clinical Trial
- (2014) Li Zhang et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- Molecular mechanisms of diabetic kidney disease
- (2014) Kimberly Reidy et al. JOURNAL OF CLINICAL INVESTIGATION
- The global implications of diabetes and cancer
- (2014) Yuankai Shi et al. LANCET
- The PI3K/p-Akt signaling pathway participates in calcitriol ameliorating podocyte injury in DN rats
- (2014) Zhixia Song et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Pretreatment with the Total Flavone Glycosides of Flos Abelmoschus manihot and Hyperoside Prevents Glomerular Podocyte Apoptosis in Streptozotocin-Induced Diabetic Nephropathy
- (2012) Lei Zhou et al. JOURNAL OF MEDICINAL FOOD
- PINCH1 Is Transcriptional Regulator in Podocytes That Interacts with WT1 and Represses Podocalyxin Expression
- (2011) Dan Wang et al. PLoS One
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