Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability

Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington’s disease

(2020) S. Fernández-García et al.   BMC BIOLOGY

Prevention of age-associated neuronal hyperexcitability with improved learning and attention upon knockout or antagonism of LPAR2

(2020) Caroline Fischer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice

(2020) Raquel Larramona-Arcas et al.   Molecular Neurodegeneration

Apolipoprotein E/Aβ Complex Accumulates in AD Cortical Synapses via apoE Receptors and Is Enhanced by APOE4

(2019) Tina Bilousova et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease

(2019) Ramsey Najm et al.   Molecular Neurodegeneration

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

(2018) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit

(2017) S.L. Angulo et al.   NEUROBIOLOGY OF DISEASE

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology

(2017) Tal Nuriel et al.   Nature Communications

Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer’s Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade

(2017) Syed F. Kazim et al.   Frontiers in Aging Neuroscience

Fast online deconvolution of calcium imaging data

(2017) Johannes Friedrich et al.   PLoS Computational Biology

Apolipoprotein E Genotype Affects Size of ApoE Complexes in Cerebrospinal Fluid

(2016) Nicolette Mary Heinsinger et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Impaired spatial memory and enhanced long-term potentiation in mice with forebrain-specific ablation of the Stim genes

(2015) Gisela Garcia-Alvarez et al.   Frontiers in Behavioral Neuroscience

Apolipoprotein E4 Produced in GABAergic Interneurons Causes Learning and Memory Deficits in Mice

(2014) J. Knoferle et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms

(2014) Jaekwang Kim et al.   MOLECULES AND CELLS

Neuronal morphometry directly from bitmap images

(2014) Tiago A Ferreira et al.   NATURE METHODS

Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice

(2014) Rebecca C. Klein et al.   NEUROBIOLOGY OF AGING

Extracellular Proteolysis of Apolipoprotein E (apoE) by Secreted Serine Neuronal Protease

(2014) Irfan Y. Tamboli et al.   PLoS One

Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy? - Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain

(2013) Peter Schönfeld et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis

(2013) Helen S. Bateup et al.   NEURON

Molecular mechanisms of homeostatic synaptic downscaling

(2013) Benjamin Siddoway et al.   NEUROPHARMACOLOGY

Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease

(2013) Keith A. Vossel et al.   JAMA Neurology

Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

(2012) Robert M. Koffie et al.   BRAIN

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer’s disease and apoE TR mouse cortex

(2011) Stephen Arold et al.   ACTA NEUROPATHOLOGICA

Homeostatic responses by surviving cortical pyramidal cells in neurodegenerative tauopathy

(2011) Johanna L. Crimins et al.   ACTA NEUROPATHOLOGICA

Hippocampal Hyperactivation Associated with Cortical Thinning in Alzheimer's Disease Signature Regions in Non-Demented Elderly Adults

(2011) D. Putcha et al.   JOURNAL OF NEUROSCIENCE

Hippocampal hyperactivation in presymptomatic familial Alzheimer's disease

(2010) Yakeel T. Quiroz et al.   ANNALS OF NEUROLOGY

Apolipoprotein E4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice

(2010) Y. Andrews-Zwilling et al.   JOURNAL OF NEUROSCIENCE

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippocampal interictal spikes disrupt cognition in rats

(2009) Jonathan K. Kleen et al.   ANNALS OF NEUROLOGY

ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons In Vivo

(2009) S. B. Dumanis et al.   JOURNAL OF NEUROSCIENCE

Distinct patterns of brain activity in young carriers of the APOE- 4 allele

(2009) N. Filippini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Candidate genes for temporal lobe epilepsy: a replication study

(2008) Annick Salzmann et al.   NEUROLOGICAL SCIENCES