Article
Chemistry, Medicinal
Aziz Unnisa, Ananda K. Chettupalli, Reem S. Alazragi, Walla Alelwani, Azzah M. Bannunah, Jameel Barnawi, Padmanabha R. Amarachinta, Suresh B. Jandrajupalli, Badria A. Elamine, Omkalthoum A. Mohamed, Talib Hussain
Summary: This study focuses on the development of a novel transdermal drug delivery system using nanostructured lipid carriers (NLCs) to deliver the antianginal drug RZ. RZ-NLCs were successfully formulated and tested for their absorption and transdermal delivery potential. The results showed that RZ-NLCs have good absorption properties and significant potential for transdermal delivery.
Article
Polymer Science
Randa Mohammed Zaki, Mohamed A. Ibrahim, Doaa H. Alshora, Amal El Sayeh Abou El Ela
Summary: This study aimed to prepare Span 60-based elastic nanovesicles using the adapted ethanol injection method, and evaluate their ability to improve transdermal permeation of tacrolimus. Different concentrations and types of penetration enhancers were assessed for their impact on the physicochemical properties of the nanovesicles. The results showed significant enhancement in in vitro release compared to pure drug suspension.
Article
Polymer Science
Hassan Raza, Shefaat Ullah Shah, Zakir Ali, Atif Ullah Khan, Irfa Basharat Rajput, Arshad Farid, Mohammed Al Mohaini, Abdulkhaliq J. J. Alsalman, Maitham A. A. Al Hawaj, Saima Mahmood, Abid Hussain, Kifayat Ullah Shah
Summary: In this study, FLU-ACT-coloaded nanostructured lipid carriers (NLCs) were successfully prepared to reduce side effects and enhance therapeutic efficacy. The optimized FLU-ACT-coloaded NLCs exhibited desired particle size, zeta potential, and encapsulation efficiency values. In vitro and ex vivo studies showed sustained release and minimal permeation of FLU and ACT from the FLU-ACT-coloaded NLC gel, compared to the FLU-ACT suspension and conventional gel.
Article
Biotechnology & Applied Microbiology
Fahad Pervaiz, Ayesha Saba, Haya Yasin, Manal Buabeid, Sobia Noreen, Abida Kalsoom Khan, Ghulam Murtaza
Summary: This study aimed to enhance drug absorption and bioavailability of paroxetine by preparing novel paroxetine-loaded solid lipid nanoparticles (SLNs) based sustained-release transdermal patches. The SLNs showed a particle size range of 113-230 nm and an entrapment efficiency of 85.14%. Paroxetine was evenly distributed in an amorphous form in SLNs, as demonstrated by DSC and PXRD analysis. SLNs formulated patches showed higher drug permeation through the skin and sustained release behavior. Draize patch test revealed no sign of erythema after applying paroxetine-loaded SLN patches.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Maria Rincon, Lupe Carolina Espinoza, Marcelle Silva-Abreu, Lilian Sosa, Jessica Pesantez-Narvaez, Guadalupe Abrego, Ana Cristina Calpena, Mireia Mallandrich
Summary: Transmucosal delivery is a common method used to treat local diseases. This study aimed to develop and optimize a nanostructured lipid carrier for the topical management of inflammatory processes on mucosal tissues. The results showed high permeation and retention of pranoprofen loaded in the lipid-based nanoparticles in various mucosal tissues, with no systemic effects observed.
Article
Chemistry, Multidisciplinary
Ming Yuan, Jiangxiu Niu, Fei Li, Huiyuan Ya, Xianghui Liu, Keying Li, Yanli Fan, Qiuyan Zhang
Summary: This study proposes a hydrogel containing CUR-encapsulated nanostructured lipid carriers (CUR-DP-NLCs gel) to enhance topical drug delivery and improve the therapeutic effect. The gel showed increased skin retention of CUR and better anti-inflammatory and analgesic activities after topical administration.
Article
Pharmacology & Pharmacy
Mohammad A. Altamimi, Afzal Hussain, Sultan Alshehri, Syed Sarim Imam, Usamah Abdulrahman Alnemer
Summary: The study compared the skin permeation of luteolin (LUT) using different carrier systems and found that cationic nanoemulsions (CNE) prepared with bergamot oil have significant advantages in permeation.
Article
Pharmacology & Pharmacy
Neeraj K. Garg, Nikunj Tandel, Sanjay Kumar Bhadada, Rajeev K. Tyagi
Summary: In this study, an NLC-based hydrogel formulation of ACE was developed and characterized, showing high stability and superior skin delivery efficiency. Compared with conventional marketed gel formulations, the NLC-based gel formulation of ACE may offer promising advantages as a nanoscale lipid carrier for topical applications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biophysics
Shan Zhu, Zhiyue Zhao, Wenxiao Qin, Tao Liu, Yi Yang, Zijing Wang, Hongfei Ma, Xiang Wang, Tao Liu, Dongli Qi, Pan Guo, JiaXin Pi, BaoCheng Tian, Han Zhang, Nan Li
Summary: Oxidative stress damage caused by sun exposure is a major cause of skin aging and skin cancer. Nanostructured lipid carriers (NLC) have been shown to improve drug permeability and stability in the skin. This study prepared NLC loaded with Oroxylin A (OA) and found that it had better therapeutic effects compared to OA solution in a cellular model of UVB radiation. Additionally, immobilizing OA-NLC in a hydrogel matrix protected the skin from damage after UV radiation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Pharmacology & Pharmacy
Doaa H. Hassan, Joseph N. Shohdy, Doaa Ahmed El-Setouhy, Mohamed El-Nabarawi, Marianne J. Naguib
Summary: The research aimed to improve the bioavailability of Zolmitriptan by developing transdermal nanostructured lipid carriers. The optimized formulation showed enhanced drug release and pharmacokinetic parameters in rabbits. The results suggest the potential of using the proposed NLCs for transdermal delivery to enhance drug bioavailability.
Article
Pharmacology & Pharmacy
Mahmoud H. Teaima, Mohamed Azmi Ahmed Mohamed, Randa Tag Abd El Rehem, Saadia A. Tayel, Mohamed A. El-Nabarawi, Shahinaze A. Fouad
Summary: The study enhanced the transdermal delivery of bisoprolol hemifumarate (BH) through differently prepared hydrogels, proving it as a successful alternative route to conventional oral tablets.
Article
Chemistry, Applied
Ali Barri, Babak Ghanbarzadeh, Maryam Mohammadi, Akram Pezeshki
Summary: Novel food-grade nanostructured lipid carrier (NLC) systems were developed using sodium caseinate as a protein surfactant, anhydrous milk fat as a solid lipid, and vitamin E acetate as a liquid oil. The optimal formulation consisted of 1% w/v caseinate protein and a 73.23/26.78 solid lipid/liquid oil ratio, resulting in small particle size, narrow size distribution, and high encapsulation efficiency. The encapsulated vitamin D3 showed improved anticancer effect in the NLC structure.
FOOD HYDROCOLLOIDS
(2023)
Article
Pharmacology & Pharmacy
Federica De Gaetano, Consuelo Celesti, Giuseppe Paladini, Valentina Venuti, Maria Chiara Cristiano, Donatella Paolino, Daniela Iannazzo, Vincenza Strano, Anna M. Gueli, Silvana Tommasini, Cinzia Anna Ventura, Rosanna Stancanelli
Summary: In recent years, the focus of scientific research has been on bioactive compounds due to their unique properties and low toxicity. However, these compounds have low solubility, chemical stability, and bioavailability. Solid lipid nanoparticles (SLNs) have emerged as potential drug delivery systems to overcome these limitations. This study successfully prepared MRN-loaded SLNs using different lipids and investigated their properties. The MRN-SLNs showed spherical and non-aggregated morphology with high encapsulation efficiency. The release studies demonstrated sustained release of MRN over 10 days. Furthermore, ex vivo permeation studies confirmed the ability of SLNs to enhance the penetration of MRN.
Article
Pharmacology & Pharmacy
Eleonora Maretti, Eliana Leo, Cecilia Rustichelli, Eleonora Truzzi, Cristina Siligardi, Valentina Iannuccelli
Summary: This study investigated the use of Nanostructured Lipid Carriers (NLC) to enhance skin permeation of the highly lipophilic beta-carotene (BC) for improved antioxidant effects. The smallest sized NLC sample showed deeper penetration into the skin barrier, potentially providing better protection against oxidative damages.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Rania S. Abdel-Rashid, Doaa A. Helal, Ahmed Adel Alaa-Eldin, Raghda Abdel-Monem
Summary: This study investigated the potential of polymeric and lipid nanocapsules as carrier systems for miconazole nitrate (MN) topical delivery, showing slow biphasic release, high drug encapsulation efficiency, and improved stability. The encapsulation strategy created formulations with promising results for MN delivery. Polymeric nanocapsules demonstrated higher cell viability and antifungal activity compared to lipid nanocapsules, suggesting potential advantages in superficial and deep fungal infections.
Article
Pharmacology & Pharmacy
Laura A. Junqueira, Hudson Polonini, Sharlene Loures, Nadia R. B. Raposo, Anderson O. Ferreira, Marcos Antonio F. Brandao
CURRENT DRUG DELIVERY
(2019)
Article
Plant Sciences
Elaine C. D. Goncalves, Pollyana M. Assis, Laura A. Junqueira, Maira Cola, Adair R. S. Santos, Nadia R. B. Raposo, Rafael C. Dutra
JOURNAL OF NATURAL PRODUCTS
(2020)
Article
Pharmacology & Pharmacy
Laura Andrade Junqueira, Atabak Ghanizadeh Tabriz, Francisco Jose Raposo, Luana Rocha Carobini, Urias Pardocimo Vaz, Marcos Antonio Fernandes Brandao, Dennis Douroumis, Nadia Rezende Barbosa Raposo
Summary: The study utilized Fused Deposition Modelling (FDM) and inkjet printing technologies to fabricate polyvinyl alcohol tablets and dispense minoxidil ethanolic solutions, demonstrating the potential for rapid development of personalized dosage forms.
Article
Pharmacology & Pharmacy
Laura Andrade Junqueira, Atabak Ghanizadeh Tabriz, Fiona Rousseau, Nadia Rezende Barbosa Raposo, Marcos Antonio Fernandes Branda, Dennis Douroumis
Summary: This study combines Fused Deposition Modelling (FDM) and jet dispensing to print polyvinyl alcohol (PVA) tablets and customize the drug dissolution rates by dispensing polymer inks loaded with rosuvastatin calcium (RSV). The drop on demand approach is used to dispense RSV-loaded inks of methacrylate (EUDRAGIT EPO), vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64), and ethylcellulose (Aqualon) in FDM printed tablets with 5 and 15 mg of active dose respectively. Physicochemical characterization confirms the molecular dispersion of RSV in the deposited inks. Different dissolution rates are achieved based on polymer solubility and drug loading. This study sets a paradigm for printing personalized dosage forms through the development of suitable inks.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Medicine, General & Internal
Shirley Braga Lima Gamonal, Aloisio Carlos Couri Gamonal, Marcos Antonio Fernandes Brandao, Laura Andrade Junqueira, Pollyana Mendonca de Assis, Nadia Rezende Barbosa Raposo
Summary: A retrospective cross-sectional study conducted in Brazil found that 24.3% of patients with plaque psoriasis also had psoriatic arthritis. Among them, asymmetric oligoarthritis was the most common type, followed by dactylitis and enthesitis. Patients with arthritis tended to be older, have a positive family history, longer disease duration, and higher PASI scores compared to those without arthritis.
SAO PAULO MEDICAL JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Yan-Ting Su, Jian Zhang
Summary: This study aimed to improve the water solubility and stability of cannabidiol (CBD) using micelle technology. CBD-loaded mixed micelles (CBD-M) composed of Poloxamer 407 (P407) and rubusoside (RUB) were successfully prepared and showed significant improvement in solubility and encapsulation efficiency. The CBD-M solution remained stable and maintained the antioxidant activity of CBD after dilution and centrifugation. These findings suggest that CBD-M could serve as a promising formulation for enhanced CBD delivery.
CURRENT DRUG DELIVERY
(2024)