Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Cell Biology
Ziming Jiang, Yiming Zhang, Yu Zhang, Zhankui Jia, Zhengguo Zhang, Jinjian Yang
Summary: The study revealed that exosomes released by bladder cancer cells can promote the immunosuppressive polarization of macrophages, facilitating tumor growth. This process is mediated by down-regulation of PTEN and activation of AKT/STAT3/6 signaling. Inhibiting the generation or secretion of exosomes can suppress the immunosuppressive transformation of macrophages, thereby inhibiting tumor growth.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Wenqing Li, Zihao Wang, Ziming Jiang, Yan Yan, Xiaohan Yao, Zhenzhen Pan, Lin Chen, Fei Wang, Ming Wang, Zhihai Qin
Summary: The study found that miR-3960 levels in bladder cancer tissue were positively correlated with patient survival time. miR-3960 inhibited bladder cancer growth and promoted drug-induced apoptosis by suppressing DEXI expression. These findings suggest that miR-3960 could be a potential therapeutic strategy against bladder cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Emily K. K. Kleczko, Joanna M. M. Poczobutt, Andre C. C. Navarro, Jennifer Laskowski, Amber M. M. Johnson, Sean P. P. Korpela, Natalia J. J. Gurule, Lynn E. E. Heasley, Katharina Hopp, Mary C. M. Weiser-Evans, Elizabeth B. B. Gottlin, Ryan T. T. Bushey, Michael J. J. Campa, Edward F. F. Patz, Joshua M. M. Thurman, Raphael A. A. Nemenoff
Summary: In this study, an orthotopic immunocompetent model of lung cancer was used to investigate the pathways altered in cancer cells recovered from tumors compared to cells grown in culture. Changes in interferon response, antigen presentation, cytokine signaling, and complement pathway induction were observed in all tumors. The activation of complement was found to be critical for tumor progression, and the expression of complement regulatory proteins protected cells from complement-mediated cell killing.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yidong Cheng, Hao Yu, Kai Li, Jiancheng Lv, Juntao Zhuang, Kexin Bai, Qikai Wu, Xiao Yang, Haiwei Yang, Qiang Lu
Summary: Accumulating evidence has shown that hsa_circ_0003098 plays a vital role in bladder cancer (BCa). The overexpression of hsa_circ_0003098 is associated with poor prognosis and promotes BCa cell proliferation, migration, invasion, and tumor growth. Mechanistically, hsa_circ_0003098 acts as a sponge for miR-377-5p, promoting the upregulation of ACAT2 expression and inducing cholesteryl ester accumulation. Therefore, hsa_circ_0003098 could serve as a potential biomarker and therapeutic target for BCa.
Article
Andrology
Feng Yuan, Xiao-Yu Yin, Yu Huang, Xiao-Wei Cai, Lu Jin, Guang-Cheng Dai, Ya-Cheng Zang, Yi Sun, Xiao-Long Liu, Bo-Xin Xue
Summary: This study found that tumor-derived exosomes play an important role in the progression of BLCA, with miR-93-5p being a particularly important molecule. Malignant cells release more exosomal miR-93-5p compared to normal cells, and tumor-derived exosomal miR-93-5p significantly promotes cell proliferation, invasion, and angiogenesis. The study also identified PTEN as the main target of miR-93-5p in BLCA and human umbilical vein endothelial cells.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2023)
Article
Cell Biology
Yuan Chen, Shiben Ji, Jianxin Ying, Yongchang Sun, Jun Liu, Guohong Yin
Summary: This study identifies a novel biomarker, KRT6A, for early diagnosis of bladder tumors and reveals its role in promoting bladder tumor progression. Additionally, it uncovers the regulatory axis of KRT6A/miR-31-5p in bladder tumor growth.
Review
Biochemistry & Molecular Biology
Magdalena Wilczak, Magdalena Surman, Malgorzata Przybylo
Summary: Bladder cancer is the 10th most common malignancy worldwide, with a high mortality rate. Altered glycosylation of bladder cancer cells plays a crucial role in disease progression and could be used for diagnostic and therapeutic purposes.
Article
Oncology
Liping Luo, Pingping Miao, Yao Ming, Jie Tao, Hongchun Shen
Summary: In this study, it was found that the expression of circZFR was upregulated in bladder cancer patients and positively correlated with patient survival rates. Inhibiting circZFR expression suppressed the proliferation, migration, and invasion of BCa cells. Additionally, circZFR was shown to promote BCa progression by upregulating WNT5A expression through sponging miR-545 and miR-1270.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Min Liang, Wenxia Yao, Boyun Shi, Xiongjie Zhu, Rui Cai, Zhongjian Yu, Weihong Guo, Huaiming Wang, Zhijie Dong, Mingzhen Lin, Xinke Zhou, Yanfang Zheng
Summary: The study identified hsa_circ_0110389 as a novel upregulated circRNA in malignant-transformed gastric cancer cells, and found that it promotes gastric cancer progression via the miR-127-5p/miR-136-5p-SORT1 pathway. This circRNA may serve as a diagnostic/prognostic biomarker and therapeutic target for gastric cancer.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Chengxin Ma, Dasa He, Pu Tian, Yuan Wang, Yunfei He, Qiuyao Wu, Zhenchang Jia, Xue Zhang, Peiyuan Zhang, Hao Ying, Zi-Bing Jin, Guohong Hu
Summary: This study reveals the crucial role of the TGF beta/miR-182/TLR4 axis in the polarization of tumor-associated macrophages (TAMs) and provides a theoretical basis for RNA-based therapeutics targeting TAMs in cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Janson Tse, Thomas Pierce, Annalisa L. E. Carli, Mariah G. Alorro, Stefan Thiem, Eric G. Marcusson, Matthias Ernst, Michael Buchert
Summary: MicroRNA-21 (miR-21) is a small, non-coding RNA that is overexpressed in gastric cancer and other solid malignancies, with both pro- and anti-tumorigenic properties. However, the regulation of miR-21 and the effects of its inhibition in gastric cancer are not fully understood. In this study, the researchers investigated the molecular pathways that control miR-21 expression in gastric cancer and evaluated the therapeutic potential of targeting miR-21 with a synthetic miR-21 antagomir. They found that miR-21 expression in early gastric cancer is dependent on Stat3, which is activated by IL-6 family cytokines through the gp130 receptor. Inhibition of miR-21 with the antagomir reduced gastric tumor growth, epithelial-to-mesenchymal transition, and matrix remodeling. The study highlights miR-21 as a promising target for anti-cancer therapy in gastric cancer.
Article
Pharmacology & Pharmacy
Yangyang Xia, Shouzhen Chen, Jianfeng Cui, Yong Wang, Xiaochen Liu, Yangli Shen, Li Gong, Xuewen Jiang, Wenfu Wang, Yaofeng Zhu, Shuna Sun, Jiangxia Li, Yongxin Zou, Benkang Shi
Summary: Hyperactivation of STAT3 is closely related to cancer progression, and BBR has been shown to have anti-tumor effects on BCa cells by inhibiting JAK1-STAT3 signaling through upregulation of miR-17-5p, which may serve as a potential therapeutic option for BCa treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Chen Yang, Zezhong Mou, Zheyu Zhang, Siqi Wu, Quan Zhou, Yiling Chen, Jian Gong, Chenyang Xu, Yuxi Ou, Xinan Chen, Xiyu Dai, Haowen Jiang
Summary: Our study revealed the tumor suppressive role of circRBPMS in bladder cancer by targeting the miR-330-3p/RAI2 axis, leading to inhibition of cell proliferation and metastasis. Downregulation of circRBPMS is associated with aggressive bladder cancer, while upregulation can suppress cell proliferation and migration.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Genetics & Heredity
Zhu Yufeng, Qi Ming, Wu Dandan
Summary: miR-320d inhibits the malignant phenotype of EGFR-positive CRC by targeting TUSC3, reducing proliferation and invasion abilities, with therapeutic potential.
FRONTIERS IN GENETICS
(2021)