Structural insights into GIRK2 channel modulation by cholesterol and PIP2

3D variability analysis: Resolving continuous flexibility and discrete heterogeneity from single particle cryo-EM

(2021) Ali Punjani et al.   JOURNAL OF STRUCTURAL BIOLOGY

Defining how multiple lipid species interact with inward rectifier potassium (Kir2) channels

(2020) Anna L. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GemSpot: A Pipeline for Robust Modeling of Ligands into Cryo-EM Maps

(2020) Michael J. Robertson et al.   STRUCTURE

A constricted opening in Kir channels does not impede potassium conduction

(2020) Katrina A. Black et al.   Nature Communications

Identification of a G-Protein-Independent Activator of GIRK Channels

(2020) Yulin Zhao et al.   Cell Reports

Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels

(2020) Yiming Niu et al.   eLife

Elevated cellular cholesterol in Familial Alzheimer’s presenilin 1 mutation is associated with lipid raft localization of β-amyloid precursor protein

(2019) Yoon Young Cho et al.   PLoS One

Interfacial Binding Sites for Cholesterol on G Protein-Coupled Receptors

(2019) Anthony G. Lee   BIOPHYSICAL JOURNAL

Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

(2019) Gregory M Martin et al.   eLife

Lipid-Dependent Regulation of Ion Channels and G Protein–Coupled Receptors: Insights from Structures and Simulations

(2019) Anna L. Duncan et al.   Annual Review of Pharmacology and Toxicology

Conduction through a narrow inward-rectifier K+ channel pore

(2019) Harald Bernsteiner et al.   JOURNAL OF GENERAL PHYSIOLOGY

Cholesterol Metabolism in the Brain and Its Association with Parkinson’s Disease

(2019) Uram Jin et al.   Experimental Neurobiology

Lipid Biomarkers in Alzheimer's Disease

(2018) Amira Zarrouk et al.   Current Alzheimer Research

Gain-of-function KCNJ6 Mutation in a Severe Hyperkinetic Movement Disorder Phenotype

(2018) Gabriella A. Horvath et al.   NEUROSCIENCE

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Accumulation of Cholesterol and Homocysteine in the Nigrostriatal Pathway of Brain Contributes to the Dopaminergic Neurodegeneration in Mice

(2018) Rajib Paul et al.   NEUROSCIENCE

GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization

(2018) Robert A. Rifkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Cholesterol up-regulates neuronal G protein-gated inwardly rectifying potassium (GIRK) channel activity in the hippocampus

(2017) Anna N. Bukiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology

(2017) Robert S. Rosenson et al.   Nature Reviews Cardiology

Hypercholesterolemia causes psychomotor abnormalities in mice and alterations in cortico-striatal biogenic amine neurotransmitters: Relevance to Parkinson's disease

(2017) Rajib Paul et al.   NEUROCHEMISTRY INTERNATIONAL

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson’s disease: Involvement of mitochondrial dysfunctions and oxidative stress

(2017) Rajib Paul et al.   PLoS One

Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol

(2017) Ian W. Glaaser et al.   Scientific Reports

Is there an association between hypercholesterolemia and depression? Behavioral evidence from the LDLr −/− mouse experimental model

(2016) Daiane Fátima Engel et al.   BEHAVIOURAL BRAIN RESEARCH

Interaction of G protein coupled receptors and cholesterol

(2016) Gerald Gimpl   CHEMISTRY AND PHYSICS OF LIPIDS

Mutations in Nature Conferred a High Affinity Phosphatidylinositol 4,5-Bisphosphate-binding Site in Vertebrate Inwardly Rectifying Potassium Channels

(2015) Qiong-Yao Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Semi-automated selection of cryo-EM particles in RELION-1.3

(2015) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Cholesterol metabolism and homeostasis in the brain

(2015) Juan Zhang et al.   Protein & Cell

Sorting Nexin 27 Regulation of G Protein-Gated Inwardly Rectifying K+ Channels Attenuates In Vivo Cocaine Response

(2014) Michaelanne B. Munoz et al.   NEURON

Identification of Novel Cholesterol-binding Regions in Kir2 Channels

(2013) Avia Rosenhouse-Dantsker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray structure of the mammalian GIRK2–βγ G-protein complex

(2013) Matthew R. Whorton et al.   NATURE

Cholesterol Down-Regulates BK Channels Stably Expressed in HEK 293 Cells

(2013) Wei Wu et al.   PLoS One

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

(2011) Matthew R. Whorton et al.   CELL

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

KCNJ6 is Associated with Adult Alcohol Dependence and Involved in Gene × Early Life Stress Interactions in Adolescent Alcohol Drinking

(2011) Toni-Kim Clarke et al.   NEUROPSYCHOPHARMACOLOGY

Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins

(2011) D. Shaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative analysis of cholesterol sensitivity of Kir channels: Role of the CD loop

(2010) Avia Rosenhouse-Dantsker et al.   Channels

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

(2010) Christian Lüscher et al.   NATURE REVIEWS NEUROSCIENCE

Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol

(2009) Y. Epshtein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

(2008) Michael A. Hanson et al.   STRUCTURE