Article
Biochemistry & Molecular Biology
Alexandra Gros, Leandre Lavenu, Jean-Luc Morel, Philippe De Deurwaerdere
Summary: The study revealed that microgravity affects brain adaptive responses in rats, particularly the monoaminergic systems, leading to changes in neurotransmitter contents and correlations between brain regions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Agoston Patthy, Janos Murai, Janos Hanics, Anna Pinter, Peter Zahola, Tomas G. M. Hokfelt, Tibor Harkany, Alan Alpar
Summary: Alzheimer's disease (AD) is a devastating neurodegenerative disorder for which an effective therapy has yet to be found. Research suggests that early damage to the ascending monoaminergic system in the brainstem may be an early sign and potential trigger of AD. In addition, cortical malfunction and local neurohistopathology are also related to the progression of AD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Lidong Wang, Shengyang Zhou, Guangshuai Liu, Tianshu Lyu, Lupeng Shi, Yuehuan Dong, Shangbin He, Honghai Zhang
Summary: This study analyzed the skin transcriptomes of American minks to uncover the molecular mechanisms underlying their fur color formation and development. The research found that keratin associated protein genes are the main genes regulating fur development, while members of the tyrosinase family genes are involved in hair color formation. The results provide molecular support for improving mink coat color and fur quality.
Article
Multidisciplinary Sciences
Aki Takahashi, Romain Durand-de Cuttoli, Meghan E. Flanigan, Emi Hasegawa, Tomomi Tsunematsu, Hossein Aleyasin, Yoan Cherasse, Ken Miya, Takuya Okada, Kazuko Keino-Masu, Koshiro Mitsui, Long Li, Vishwendra Patel, Robert D. Blitzer, Michael Lazarus, Kenji F. Tanaka, Akihiro Yamanaka, Takeshi Sakurai, Sonoko Ogawa, Scott J. Russo
Summary: The glutamatergic projections from the lateral habenula (LHb) to the dorsal raphe nucleus (DRN) modulate male mice's aggressive behavior. Inhibition of LHb-DRN projection blocks the increase in aggression after social instigation. The activity of this pathway is not necessary for the expression of species-typical aggressive behavior but essential for the increase in aggression resulting from social instigation.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Tiziana Carandini, Mara Cercignani, Daniela Galimberti, Elio Scarpini, Marco Bozzali
Summary: Dopamine, noradrenaline, and serotonin play crucial roles in the interaction between the nervous and immune systems by binding to cell-receptors and regulating their function. Dysregulation of monoamines may contribute to fatigue and depression in Multiple Sclerosis, with potential for targeted drug treatments.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Gunasingh Jeyaraj Masilamoni, Allison Weinkle, Stella M. Papa, Yoland Smith
Summary: This study found decreased serotonergic and catecholaminergic innervation in the frontal cortex at early stages of Parkinson's disease. The use of MPTP-treated monkeys as animal models revealed that these changes may contribute to early non-motor symptoms in PD.
Article
Neurosciences
Yukio Ago, Rei Yokoyama, Satoshi Asano, Hitoshi Hashimoto
Summary: The antidepressant effects of ketamine may be related to both the dopaminergic system and the serotonergic system, while the effects of (R)-ketamine may be independent of the monoaminergic system. Ketamine metabolites differ in their ability to regulate monoamine neurotransmitters, and some metabolites may share common serotonergic signaling mechanisms with ketamine.
Article
Behavioral Sciences
Kristi Liiver, Sophie Imbeault, Marianna Skolnaja, Tanel Kaart, Margus Kanarik, Karita Laugus, Jade De Wettinck, Aleksander Pulver, Ruth Shimmo, Jaanus Harro
Summary: Sex differences in exploratory behavior were observed in male and female rats. Female rats displayed higher exploratory activity and a normal distribution, while males exhibited a bimodal distribution. There were no major effects of litter or estrous cycle. Differences in monoamine metabolism between male and female rats were found, including lower dopamine levels in the frontal cortex and higher levels of 3,4-dihydroxyphenylacetic acid (DOPAC) in the raphe area in males. Females had higher levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the dorsal striatum, but lower levels in the locus coeruleus area. There were also differences in noradrenaline (NA) and normetanephrine (NMN) levels between the sexes. Female rats displayed not only higher levels of exploration, but also a distinct population distribution of this behavior, which may be related to differences in monoaminergic systems.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Cell Biology
D. Kavindi Weerasinghe, Jason M. Hodge, Julie A. Pasco, Rasika M. Samarasinghe, Behnaz Azimi Manavi, Lana J. Williams
Summary: This article provides an overview of the mechanisms of action of antipsychotics and the expression profiles of dopamine, serotonin, and adrenergic receptors during osteoclastogenesis and osteoblastogenesis, aiming to elucidate the effects of antipsychotic use on bone.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Fei Huang, Xiaojun Wu
Summary: Researches show that gut microbiota play a crucial role in neurotransmitter modulation in the brain, which is closely related to the pathophysiology of anxiety and depression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Karolina Noworyta, Agata Cieslik, Rafal Rygula
Summary: This review summarizes recent advances in understanding biased cognition in depressive disorder, focusing on pessimistic judgment bias and abnormal response to negative feedback. The discussion includes neurochemical mechanisms identified through genetic, molecular, and pharmacological studies, as well as experimental approaches to depression treatment based on improved understanding of cognitive substrates.
Review
Clinical Neurology
Francesca A. Cupaioli, Fabio A. Zucca, Cinzia Caporale, Klaus-Peter Lesch, Luca Passamonti, Luigi Zecca
Summary: In modern societies, efforts are being made to improve the quality of life by better understanding the brain's influence on aggression. Neurobiological research shows that changes in specific brain regions are related to aggression, and genetic and environmental factors also play a significant role in aggressiveness.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Stina Borchers, Jil Carl, Katharina Schormair, Jean-Philippe Krieger, Mohammed Asker, Christian E. Edvardsson, Elisabeth Jerlhag, Karolina P. Skibicka
Summary: Studies show that contrary to the common notion that female rats are not aggressive, female rats also exhibit aggressive behavior outside of maternal context and find winning in aggressive interactions rewarding. This reward is similar to that experienced by male rats and is dopamine-dependent.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Anatomy & Morphology
Isabel Perez-Santos, Miguel Angel Garcia-Cabezas, Carmen Cavada
Summary: Neuromodulatory afferents to the thalamus are important for information transmission, but the descriptions of these inputs in primates have methodological divergences, making them less comparable. This article proposes reproducible methodologies and terminologies for mapping the primate thalamus and suggests the use of standardized planes and terminology for consistent identification of thalamic nuclei.
BRAIN STRUCTURE & FUNCTION
(2023)
Review
Biochemistry & Molecular Biology
Jolyon A. Jones, Katharina Zuhlsdorff, Jeffrey W. Dalley
Summary: Drug addiction is manifested in some individuals and involves multifaceted processes such as cognitive control failures. Impulsivity, which includes reckless behavior without foresight, underlies most drug-taking behavior. While the neural substrates of the relationship between trait impulsivity and drug compulsion are poorly understood, advances have been made in studying limbic cortico-striatal circuits and neuromodulatory influences.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Physics, Atomic, Molecular & Chemical
A. V. Kulikov, V. R. Bogatyrenko, A. I. Grigorash
APPLIED MAGNETIC RESONANCE
(2019)
Article
Chemistry, Multidisciplinary
S. V. Kurmaz, V. D. Sen', A. V. Kulikov, D. V. Konev, V. A. Kurmaz, A. A. Balakina, A. A. Terent'ev
RUSSIAN CHEMICAL BULLETIN
(2019)
Article
Biochemistry & Molecular Biology
N. A. Sinyakova, E. Yu Bazhenova, E. A. Kulikova, D. Fursenko, A. Kulikov
Article
Biochemistry & Molecular Biology
E. A. Kulikova, D. V. Fursenko, E. Yu. Bazhenova, A. V. Kulikov
Article
Medicine, Research & Experimental
E. A. Kulikova, D. V. Bazovkina, V. S. Evsyukova, A. V. Kulikov
Summary: The acute treatment with antidepressant drugs, imipramine and citalopram, was found to affect the behavior and activity of striatal-enriched tyrosine protein phosphatase (STEP) in the whole brain of zebrafish Danio rerio.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
I. I. Faingold, D. A. Poletaeva, Yu. V. Soldatova, A. V. Smolina, O. V. Pokidova, A. V. Kulikov, N. A. Sanina, R. A. Kotelnikova
Summary: The study demonstrates that BSA effectively stabilizes the TNIC complex, prolonging its role as an NO donor and inhibiting lipid peroxidation-induced oxidative stress. Additionally, TNIC-BSA was found to inhibit the catalytic activity of mitochondrial membrane-bound enzymes. These findings suggest the practical application of TNIC-BSA in combating socially significant diseases.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
I. E. Sorokin, V. S. Evsyukova, A. V. Kulikov
Summary: Reduced daylight duration leads to the development of seasonal affective disorder (SAD) in sensitive individuals, and zebrafish can be used as a promising model to study the involvement of serotonin (5-HT) in the mechanism of SAD.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Medicine, Research & Experimental
P. D. Komleva, E. Yu. Bazhenova, N. V. Khotskin, E. A. Kulikova, A. V. Kulikov
Summary: The study examined the effect of the C1473G polymorphism in the Tph2 gene on motor activity and serotonin levels in the brain. It was found that this polymorphism influenced the level of 5-HIAA in the cortex and striatum. This finding is important for understanding the role of tryptophan hydroxylase 2 in the nervous system's adaptation during infections and for predicting and reducing the risks of mental disorders.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Darya V. Bazovkina, Dariya V. Fursenko, Vladimir S. Naumenko, Aleksandr V. Kulikov
Summary: The study showed that acute ethanol administration has a significant impact on the expression of the c-fos gene and the metabolism of serotonin and catecholamines in mouse brains. The C1473G polymorphism in the Tph2 gene plays an important role in the expression pattern of c-fos and biogenic amine metabolism.
BIOCHEMISTRY-MOSCOW
(2023)
Article
Medicine, Research & Experimental
A. B. Arefieva, A. V. Kulikov
Summary: We have developed a rapid and sensitive assay for measuring the activity of tryptophan hydroxylase 2 enzyme. This method is based on the fluorescence of the complex formed between 5-hydroxytryptophan (5-HTP) and o-phthalic aldehyde. It has been shown to be comparable to the standard chromatographic method in terms of accuracy and sensitivity. This new method offers a simplified and cost-effective solution for measuring tryptophan hydroxylase 2 activity, making it accessible to a wider range of research laboratories.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Behavioral Sciences
Darya Bazovkina, Nina B. Illarionova, Elizabeth A. Kulikova, Ekaterina Yu. Bazhenova, Nadezhda A. Sinyakova, Nikita V. Khotskin, Sergey Nikitin, Vasily S. Lankin, Elena E. Terenina, Oleg V. Trapezov, Aleksandr V. Kulikov
Summary: This study provides the first evidence of brain adaptation in pigs tolerant to the presence of humans, which is a behavioral trait favoring domestication. The study compares the behavior and neurochemical profiles of piglets with high and low tolerance to human presence, finding significant differences in cortisol levels, neurotransmitter systems, and neurotrophic markers.
BRAIN BEHAVIOR AND EVOLUTION
(2023)
Article
Chemistry, Physical
S. I. Kuzina, A. I. Bol'shakov, A. V. Kulikov, A. I. Mikhailov
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A
(2020)
Article
Biology
A. V. Kulikov, L. V. Arkhipova, P. A. Kulikova, A. A. Glazkov, E. Yu. Mndlyan, V. B. Gavrilyuk, D. A. Kulikov
Review
Veterinary Sciences
Dimitar Nakov, Slavcha Hristov, Branislav Stankovic, Francois Pol, Ivan Dimitrov, Vlatko Ilieski, Pierre Mormede, Julie Nerve, Elena Terenina, Blandine Lieubeau, Dimitrios K. Papanastasiou, Thomas Bartzanas, Tomas Norton, Deborah Piette, Emanuela Tullo, D. E. van Dixhoorn
FRONTIERS IN VETERINARY SCIENCE
(2019)