期刊
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
卷 106, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2020.110059
关键词
Aggression; imaging of aggressive brain; brain regions of aggression; dopamine and serotonin in aggression; genetics of aggression
资金
- Italian Ministry of Education, University, and Research (MIUR) - National Research Council of Italy (CNR) - Progetto Premiale L'amministrazione della giustizia in Italia: il caso della neurogenetica e delle neuroscienze
- MIUR - National Research Programme (PNR) - CNR Flagship InterOmics Project [PB.P05]
- MIUR - PNR - CNR Aging Program
- Medical Research Council (MRC) at the University of Cambridge, UK [MR/P01271X/1]
- MRC [MR/P01271X/1] Funding Source: UKRI
In modern societies, efforts are being made to improve the quality of life by better understanding the brain's influence on aggression. Neurobiological research shows that changes in specific brain regions are related to aggression, and genetic and environmental factors also play a significant role in aggressiveness.
In modern societies, there is a strive to improve the quality of life related to risk of crimes which inevitably requires a better understanding of brain determinants and mediators of aggression. Neurobiology provides powerful tools to achieve this end. Pre-clinical and clinical studies show that changes in regional volumes, metabolism-function and connectivity within specific neural networks are related to aggression. Subregions of prefrontal cortex, insula, amygdala, basal ganglia and hippocampus play a major role within these circuits and have been consistently implicated in biology of aggression. Genetic variations in proteins regulating the synthesis, degradation, and transport of serotonin and dopamine as well as their signal transduction have been found to mediate behavioral variability observed in aggression. Gene-gene and gene-environment interactions represent additional important risk factors for aggressiveness. Considering the social burden of pathological forms of aggression, more basic and translational studies should be conducted to accelerate applications to clinical practice, justice courts, and policy making.
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