Article
Medicine, Research & Experimental
Elisabetta Vulpis, Francesca Giulimondi, Luca Digiacomo, Alessandra Zingoni, Reihaneh Safavi-Sohi, Shahriar Sharifi, Giulio Caracciolo, Morteza Mahmoudi
Summary: Gender plays a significant role in nanomedicine vaccine research, impacting cellular uptake and immune responses. A comprehensive understanding of gender differences is crucial for the development of safer and more effective gender-specific vaccines.
MOLECULAR PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Shahriar Sharifi, Giulio Caracciolo, Daniela Pozzi, Luca Digiacomo, Jennifer Swann, Heike E. Daldrup-Link, Morteza Mahmoudi
Summary: Gender differences can influence the therapeutic efficacy, side effects, and drug delivery safety of nanomedicine products. A deep understanding of the effects of sex on nano-based drug delivery agents can greatly improve the risk assessment process, leading to safer formulations, successful clinical translation, and improved therapeutic efficacies for both sexes.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Pediatrics
Qianfan Yang, Kameron Kennicott, Runqi Zhu, Jooyong Kim, Hunter Wakefield, Katelyn Studener, Yun Liang
Summary: The majority of autoimmune diseases affect more women than men, indicating the important role of sex hormones in regulating immune response. Current research emphasizes the significance of sex hormones in both immune and metabolic regulation. Puberty is characterized by significant changes in sex hormone levels and metabolism, which may contribute to the difference in autoimmunity bias between men and women.
FRONTIERS IN PEDIATRICS
(2023)
Article
Chemistry, Multidisciplinary
Yu Zhang, Sheng Ma, Xinming Liu, Yudi Xu, Jiayu Zhao, Xinghui Si, Hongxiang Li, Zichao Huang, Zhenxin Wang, Zhaohui Tang, Wantong Song, Xuesi Chen
Summary: A programmable immune activation nanomedicine (PIAN) is reported in this study, which sequentially finishes multiple steps after intravenous injection and elicits robust antitumor immunity in situ. This innovative approach provides a new framework for designing programmable nanomedicine as an in situ cancer vaccine for cancer immunotherapy.
ADVANCED MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Z. Y. Wan, V. C. L. Lin, Yue Gen Hua
Summary: Sexual dimorphism is common in the animal kingdom, with mechanisms of sexual size dimorphism being limitedly understood. Tilapia, a type of cichlid fish, has been studied to understand the differences in gene expression between males and females in the brain, particularly focusing on the Pomc gene and its relation to growth and feeding behavior in zebrafish. Results suggest that Pomc contributes to sexual size dimorphism, with high estrogen levels in females promoting its expression and suppressing feeding, leading to slower growth in female tilapias.
MARINE BIOTECHNOLOGY
(2021)
Review
Cell Biology
Yitian Zhang, Weihui Zeng, Yumin Xia
Summary: Fibrosis is a common pathological condition associated with abnormal repair after tissue injury, and the TWEAK/Fn14 pathway plays a crucial role in this process.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Anatomy & Morphology
Sarah E. E. Seese, Sanaa Muheisen, Natalie Gath, Jeffrey M. M. Gross, Elena V. V. Semina
Summary: This study identified heat shock proteins as interacting partners of MAB21L2/mab21l2 and suggests a role for this interaction in vertebrate eye development.
DEVELOPMENTAL DYNAMICS
(2023)
Review
Chemistry, Multidisciplinary
Saeid Moghassemi, Arezoo Dadashzadeh, Ricardo Bentes Azevedo, Olivier Feron, Christiani A. Amorim
Summary: Photodynamic therapy (PDT) combines photochemistry and photophysics sciences for cancer therapy, showing significant potential. Despite advantages and progress, common photosensitizing agents have limitations, which can be addressed by using liposomes as carriers for PS.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Immunology
Ravi Vattepu, Sunny Lyn Sneed, Robert M. Anthony
Summary: Antibodies play a critical role in linking the adaptive immune response to the innate immune system. Human antibodies are categorized into different classes and undergo post-translational modification by sugars. The structure of glycans on antibodies, especially sialic acid, significantly influences their functions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Nura Adam Mohamed, Luisa Zupin, Sarah Ismail Mazi, Hebah A. Al-Khatib, Sergio Crovella
Summary: Human monkeypox is a rare viral zoonosis that has become a global epidemic, with recent reports suggesting its increase in cases worldwide. There is currently no proven treatment or vaccine for the disease, but developing a nanomedicine-based preventative strategy shows promising potential. However, limited and incomplete data in this area calls for further investigation to develop effective counteractive measures against this emerging virus and prevent a potential pandemic, especially in the recovery phase from the COVID-19 pandemic.
Review
Pharmacology & Pharmacy
Victor M. Moreno, Alejandro Baeza
Summary: The use of nanocarriers to deliver antitumor agents to solid tumors is challenging due to biological barriers. Recent research has suggested a paradigm shift, targeting the immune system instead of tumoral cells to exploit its ability for capturing and interacting with nanometric particles. Bacteria are proposed as valuable carriers to improve the accumulation and penetration of nanomedicines into malignancies, utilizing their natural immunogenicity.
Review
Biochemistry & Molecular Biology
Megan M. Jorgensen, Pilar de la Puente
Summary: This article introduces the role of Leukemia Inhibitory Factor (LIF) in various diseases and tumors, as well as its potential mechanisms of action. Exploring the role of LIF in normal physiology and non-cancer pathologies can provide important insights into its dysregulation in cancer. LIF expression in various cancers is associated with features and overall survival.
Article
Chemistry, Multidisciplinary
Zijin Lin, Zahra Jiwani, Vahid Serpooshan, Haniyeh Aghaverdi, Phillip. C. Yang, Aitor Aguirre, Joseph. C. Wu, Morteza Mahmoudi
Summary: Sex-specific considerations are crucial in the development of nanomedicine technologies for the prevention, diagnosis, and treatment of cardiovascular disease. This Perspective emphasizes the need for robust and accurate consideration of sex in the design and development of safer and more efficient nanomedicine approaches.
Review
Pharmacology & Pharmacy
Zhiwen Fu, Liu Wang, Shijun Li, Fen Chen, Kathy Ka-Wai Au-Yeung, Chen Shi
Summary: miRNAs play a crucial role in cancer treatment by regulating gene expression and influencing the growth and survival of cancer cells. They are considered an attractive target for anticancer drug development and have shown promising results in research and therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Suyeon Kim, Han Young Chung, Joon-Gi Kwon, Sang Ho Choi, Ju-Hoon Lee
Summary: Vibrio vulnificus, a well-known pathogen causing food-borne illnesses, has a new strain isolated in South Korea with two circular DNA chromosomes, one of which contains a super integron likely associated with antibiotic resistance and pathogenicity. Pan-genome analysis revealed important virulence factors in the core genome regions, while unique genes related to resistance ability were found in accessory genome regions. RNA-Seq analysis showed that consumption of contaminated fresh crab could provide a large number of V. vulnificus to humans, posing a potential danger. Biocontrol of V. vulnificus may be critical for ensuring seafood safety.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Analytical
Ali Akbar Ashkarran, Shahriar Shari, Christoffer K. Abrahamsson, Morteza Mahmoudi
Summary: This study presents a method for in-situ monitoring of photopolymerization of water-soluble bifunctional macromers using a magnetic levitation system. The conversion rate of polyethylene glycol diacrylate was successfully measured by observing changes in levitation heights.
ANALYTICA CHIMICA ACTA
(2022)
Article
Pharmacology & Pharmacy
Yadollah Omidi, Maha Mobasher, Ana M. Castejon, Morteza Mahmoudi
Summary: Breast cancer is the second major cause of death among women worldwide, with a high mortality rate. The unique tumor microenvironment created by breast cancer cells allows them to evade immune surveillance, making conventional chemotherapy and immunotherapy ineffective. Overexpressed tumor markers in breast cancer cells can be targeted for detection and therapy, with HER2 being a clinically valid molecular target.
JOURNAL OF DRUG TARGETING
(2022)
Letter
Multidisciplinary Sciences
Susanne Tauber, Morteza Mahmoudi
Article
Chemistry, Multidisciplinary
Liqun Ning, Jenny Shim, Martin L. Tomov, Rui Liu, Riya Mehta, Andrew Mingee, Boeun Hwang, Linqi Jin, Athanasios Mantalaris, Chunhui Xu, Morteza Mahmoudi, Kelly C. Goldsmith, Vahid Serpooshan
Summary: This study utilizes 3D bioprinting and NB spheroids to create a vascular model of NB with an endothelialized microenvironment. The results suggest that NB exhibits increased aggression in this model, and metabolic, cytokine, and gene expression profiles can be assessed under different TME conditions.
Article
Multidisciplinary Sciences
Rahimeh B. Attasgah, Brenda Velasco-Rodriguez, Alberto Pardo, Javier Fernandez-Vega, Lilia Arellano-Galindo, Luis Carlos Rosales-Rivera, Gerardo Prieto, Silvia Barbosa, Jose Felix Armando Soltero, Morteza Mahmoudi, Pablo Taboada
Summary: Hybrid hydrogels composed of chitosan, hyaluronic acid, and collagen were prepared by polyelectrolyte complex self-assembly. These hydrogels exhibited good porosity and storage modulus, making them suitable for tissue engineering and transdermal drug delivery applications.
Review
Chemistry, Multidisciplinary
Carmen J. Gil, Lan Li, Boeun Hwang, Melissa Cadena, Andrea S. Theus, Tyler A. Finamore, Holly Bauser-Heaton, Morteza Mahmoudi, Ryan K. Roeder, Vahid Serpooshan
Summary: Tissue engineering is a multidisciplinary field that focuses on generating or regenerating functional three-dimensional tissues for disease modeling, drug screening, and therapeutic purposes. Advanced biological and engineering methods are utilized to enhance and customize tissue engineered scaffolds, while tunable drug delivery mechanisms are incorporated to address clinical challenges. The review covers the mechanisms and recent developments in drug delivery vehicles, loading strategies, and monitoring/release kinetics of embedded drugs in engineered scaffolds, as well as the trend of using stimuli driven biopolymer scaffolds for precise spatiotemporal control of drug release.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Inorganic & Nuclear
Mohammad Reza Sepand, Banafsheh Bigdelou, Armin Salek Maghsoudi, Nima Sanadgol, Jim Q. Ho, Prashant Chauhan, Mohammad Raoufi, Atefeh Kermanian, Rahim Esfandyarpour, Mohammad Javad Hajipour, Steven Zanganeh
Summary: Ferroptosis is an iron-mediated cell death that combines cell metabolism, redox status, and human disease. Excessive reactive oxygen species (ROS) can lead to cellular oxidative changes, suppress protein activity, and trigger cell death. This review summarizes the effects of environmental chemical exposure on cellular redox signaling, ferroptosis, and cell death, providing critical information to mitigate the impact of ferroptosis on human health.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Physical
Behnaz Ghaemi, Mohammad Javad Hajipour
Summary: This study investigates the biological impacts of different nanoparticles on cancer cells at different pH levels. The researchers found that a slight change in the pH of the cancer cell microenvironment significantly affects the cellular uptake efficacy and toxicity mechanism of the nanoparticles. The nanoparticles exhibited more toxic effects against cancer cells at physiological pH compared to acidic pH, and they also affected different phases of the cell cycle at different pH levels. Additionally, cancer cells expressed higher levels of interleukins involved in cancer cell resistance at acidic pH. The findings highlight the importance of considering the extracellular pH of cancer cells in future cancer nanomedicine research.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Mohammad J. Hajipour, Reihaneh Safavi-Sohi, Shahriar Sharifi, Nouf Mahmoud, Ali Akbar Ashkarran, Elizabeth Voke, Vahid Serpooshan, Milad Ramezankhani, Abbas S. Milani, Markita P. Landry, Morteza Mahmoudi
Summary: The protein corona is formed spontaneously on nanoparticle surfaces in biological systems/fluids. Characterizing the protein corona is crucial for the development of safe and efficient diagnostic and therapeutic nanomedicine products. This review analyzed 470 papers from 2000 to 2021, covering 1702 nanoparticle systems, and revealed key findings regarding the types of nanoparticles studied, the underrepresentation of lipid-based NPs in corona research, the use of new methods to improve reliability, the focus on personalized medicine, and the importance of careful characterization of nanoparticles after corona formation.
Article
Chemistry, Multidisciplinary
Cintia Marques, Mohammad Javad Hajipour, Ceilia Marets, Alexandra Oudot, Reihaneh Safavi-sohi, Melanie Guillemin, Gerrit Borchard, Olivier Jordan, Lucien Saviot, Lionel Maurizi
Summary: The therapeutic efficacy and side effects of nanoparticles (NPs) depend on their circulation time in the body. The adsorbed coronaproteins on NPs determine their plasma half-lives, and it is important to identify the proteins that influence their circulation time. This study analyzed the in vivo circulation time and protein composition of superparamagnetic iron oxide nanoparticles (SPIONs) with different surface charges/chemistries. SPIONs with neutral and positive charges had the longest and shortest circulation times, respectively. The composition of the corona-coated NPs also affected their circulation time, with certain proteins playing a role in determining their systemic circulation time.
Article
Medicine, Research & Experimental
Vidyani Suryadevara, Mohammad Javad Hajipour, Lisa C. Adams, Nour Mary Aissaoui, Ali Rashidi, Louise Kiru, Ashok J. Theruvath, Ching-Hsin Huang, Masahiro Maruyama, Masanori Tsubosaka, Jennifer K. Lyons, Wei (Emma) Wu, Raheleh Roudi, Stuart B. Goodman, Heike E. Daldrup-Link
Summary: This study developed an efficient labeling method for MSCs using MegaPro nanoparticles, which showed better effectiveness in tracking MSCs compared to ferumoxytol nanoparticles. MegaPro-labeled MSCs demonstrated enhanced MRI tracking without affecting cell viability or differentiation.
Article
Nanoscience & Nanotechnology
Shahriar Sharifi, Amir Ata Saei, Hassan Gharibi, Nouf N. Mahmoud, Shannon Harkins, Naruphorn Dararatana, Erika M. Lisabeth, Vahid Serpooshan, Akos Vegvari, Anna Moore, Morteza Mahmoudi
Summary: Albumin-based hydrogels, especially the non-immunogenic photocurable version described in the study, demonstrate excellent biocompatibility and anti-inflammatory properties, making them promising materials for biomedical applications. The modifications and cross-linking of methacrylated HSA were found to reduce macrophage adhesion and inflammatory pathways, with potential for use in passivation coatings and other biomedical applications. In vitro and Ex-Ovo assay results confirmed the biocompatibility and slight angiogenesis-modulating effects of the photocurable albumin hydrogels.
ACS APPLIED BIO MATERIALS
(2022)
Article
Chemistry, Physical
Ali Akbar Ashkarran, Atiyeh Hosseini, Reza Loloee, George Perry, Ki-Bum Lee, Mikael Lund, Mohammad Reza Ejtehadi, Morteza Mahmoudi
Summary: We investigated the charge transport characteristics of self-assembled monolayers (SAMs) of short tau peptides using electron tunneling rates and quantum mechanical simulation. Our findings showed that the conformation and phosphorylation of short peptides can significantly affect their electron tunneling current and energy levels.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Letter
Pharmacology & Pharmacy
Morteza Mahmoudi, Sherry Moss, Loraleigh Keashly
Correction
Nanoscience & Nanotechnology
Steven Zanganeh, Petrina Georgala, Claudia Corbo, Leila Arabi, Jim Q. Ho, Najme Javdani, Mohammad R. Sepand, Kiara Cruickshank, Luis F. Campesato, Chien-Huan Weng, Saeed Hemayat, Chrysafis Andreou, Ricardo Alvim, Gregor Hutter, Marjan Rafat, Morteza Mahmoudi
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)