The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

(2020) Michele M. Nava et al.   CELL

Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain

(2019) Amelia J Thompson et al.   eLife

The nature and intensity of mechanical stimulation drive different dynamics of MRTF-A nuclear redistribution after actin remodeling in myoblasts

(2019) Lorraine Montel et al.   PLoS One

Origin of Slow Stress Relaxation in the Cytoskeleton

(2019) Yuval Mulla et al.   PHYSICAL REVIEW LETTERS

High stretchability, strength, and toughness of living cells enabled by hyperelastic vimentin intermediate filaments

(2019) Jiliang Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active Mechanics Reveal Molecular-Scale Force Kinetics in Living Oocytes

(2018) Wylie W. Ahmed et al.   BIOPHYSICAL JOURNAL

Intermediate filaments control collective migration by restricting traction forces and sustaining cell–cell contacts

(2018) Chiara De Pascalis et al.   JOURNAL OF CELL BIOLOGY

Molecular clutch drives cell response to surface viscosity

(2018) Mark Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Mechanotransduction by Molecular Clutch Dynamics

(2018) Alberto Elosegui-Artola et al.   TRENDS IN CELL BIOLOGY

Cancer cell adaptation to hypoxia involves a HIF‐GPRC5A‐YAP axis

(2018) Alexander Greenhough et al.   EMBO Molecular Medicine

Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress

(2018) Xiaodong Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Active superelasticity in three-dimensional epithelia of controlled shape

(2018) Ernest Latorre et al.   NATURE

Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour

(2018) Giovanna Brusatin et al.   NATURE MATERIALS

Force loading explains spatial sensing of ligands by cells

(2017) Roger Oria et al.   NATURE

Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second

(2017) Nico Strohmeyer et al.   NATURE MATERIALS

Functional assessment of the ex vivo vocal folds through biomechanical testing: A review

(2016) Gregory R. Dion et al.   Materials Science & Engineering C-Materials for Biological Applications

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

The mechanical response of talin

(2016) Mingxi Yao et al.   Nature Communications

Cells Sensing Mechanical Cues: Stiffness Influences the Lifetime of Cell–Extracellular Matrix Interactions by Affecting the Loading Rate

(2015) Li Jiang et al.   ACS Nano

Role of Mechanotransduction in Vascular Biology: Focus on Thoracic Aortic Aneurysms and Dissections

(2015) J. D. Humphrey et al.   CIRCULATION RESEARCH

Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices

(2015) Haguy Wolfenson et al.   NATURE CELL BIOLOGY

Hydraulic fracture during epithelial stretching

(2015) Laura Casares et al.   NATURE MATERIALS

Cyclic stretching of soft substrates induces spreading and growth

(2015) Yidan Cui et al.   Nature Communications

Substrate stress relaxation regulates cell spreading

(2015) Ovijit Chaudhuri et al.   Nature Communications

FibrilTool, an ImageJ plug-in to quantify fibrillar structures in raw microscopy images

(2014) Arezki Boudaoud et al.   Nature Protocols

3D Viscoelastic traction force microscopy

(2014) Jennet Toyjanova et al.   Soft Matter

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

Cellular Response to Substrate Rigidity Is Governed by Either Stress or Strain

(2013) Ai Kia Yip et al.   BIOPHYSICAL JOURNAL

Determinants of Maximal Force Transmission in a Motor-Clutch Model of Cell Traction in a Compliant Microenvironment

(2013) Benjamin L. Bangasser et al.   BIOPHYSICAL JOURNAL

Myosin II in mechanotransduction: master and commander of cell migration, morphogenesis, and cancer

(2013) Rocío Aguilar-Cuenca et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Integrin-dependent force transmission to the extracellular matrix by  -actinin triggers adhesion maturation

(2013) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Cells test substrate rigidity by local contractions on submicrometer pillars

(2012) S. Ghassemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterizing the mechanics of cultured cell monolayers

(2012) A. R. Harris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linear and Nonlinear Rheology of Living Cells

(2011) Philip Kollmannsberger et al.   Annual Review of Materials Research

A pharmacological cocktail for arresting actin dynamics in living cells

(2011) Grace E. Peng et al.   MOLECULAR BIOLOGY OF THE CELL

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Balancing forces: architectural control of mechanotransduction

(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stretchy Proteins on Stretchy Substrates: The Important Elements of Integrin-Mediated Rigidity Sensing

(2010) Simon W. Moore et al.   DEVELOPMENTAL CELL

Quantifying cellular adhesion to extracellular matrix components by single-cell force spectroscopy

(2010) Jens Friedrichs et al.   Nature Protocols

Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression

(2010) P. Schedin et al.   Cold Spring Harbor Perspectives in Biology

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Reinforcement versus Fluidization in Cytoskeletal Mechanoresponsiveness

(2009) Ramaswamy Krishnan et al.   PLoS One

Clustering of  5 1 integrins determines adhesion strength whereas  v 3 and talin enable mechanotransduction

(2009) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Micropatterning of Single Endothelial Cell Shape Reveals a Tight Coupling between Nuclear Volume in G1 and Proliferation

(2008) Pere Roca-Cusachs et al.   BIOPHYSICAL JOURNAL

Do Cells Sense Stress or Strain? Measurement of Cellular Orientation Can Provide a Clue

(2008) Rumi De et al.   BIOPHYSICAL JOURNAL

Two Characteristic Regimes in Frequency-Dependent Dynamic Reorientation of Fibroblasts on Cyclically Stretched Substrates

(2008) Simon Jungbauer et al.   BIOPHYSICAL JOURNAL

Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed

(2008) Margaret L. Gardel et al.   JOURNAL OF CELL BIOLOGY

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

Theory, analysis, and interpretation of single-molecule force spectroscopy experiments

(2008) O. K. Dudko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

One-lung overventilation does not induce inflammation in the normally ventilated contralateral lung

(2008) Isaac Almendros et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE

Role of Cyclic Strain Frequency in Regulating the Alignment of Vascular Smooth Muscle Cells In Vitro

(2007) Bo Liu et al.   BIOPHYSICAL JOURNAL