Discovery of VU6028418: A Highly Selective and Orally Bioavailable M4 Muscarinic Acetylcholine Receptor Antagonist

Applications of deuterium in medicinal chemistry

(2019) Tracey Pirali et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres

(2019) Qingyi Yang et al.   ACS Medicinal Chemistry Letters

Roles of the M4 acetylcholine receptor in the basal ganglia and the treatment of movement disorders

(2019) Mark S. Moehle et al.   MOVEMENT DISORDERS

The neurobiological basis for novel experimental therapeutics in dystonia

(2019) Anthony M. Downs et al.   NEUROBIOLOGY OF DISEASE

Crystal structure of the M5muscarinic acetylcholine receptor

(2019) Ziva Vuckovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric modulators targeting CNS muscarinic receptors

(2018) Andreas Bock et al.   NEUROPHARMACOLOGY

Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists

(2018) Hongtao Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of VU2957 (Valiglurax): An mGlu4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson’s Disease

(2018) Joseph D. Panarese et al.   ACS Medicinal Chemistry Letters

Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

(2016) Paula Ruiz-Castillo et al.   CHEMICAL REVIEWS

Characterization of PCS1055, a novel muscarinic M4 receptor antagonist

(2016) Carrie H. Croy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

(2016) David M. Thal et al.   NATURE

Antipsychotic-like Effects of M 4 Positive Allosteric Modulators Are Mediated by CB 2 Receptor-Dependent Inhibition of Dopamine Release

(2016) Daniel J. Foster et al.   NEURON

Experimentally Validated hERG Pharmacophore Models as Cardiotoxicity Prediction Tools

(2014) Jadel M. Kratz et al.   Journal of Chemical Information and Modeling

New Potent Antibacterial Oxazolidinone (MRX-I) with an Improved Class Safety Profile

(2014) Mikhail F. Gordeev et al.   JOURNAL OF MEDICINAL CHEMISTRY

Muscarinic acetylcholine receptors: novel opportunities for drug development

(2014) Andrew C. Kruse et al.   NATURE REVIEWS DRUG DISCOVERY

Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc

(2010) Rémy C. Lemoine et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes

(2010) Tang Peng Cho et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure†

(2009) Serena Scapecchi et al.   JOURNAL OF MEDICINAL CHEMISTRY