Review
Oncology
Jia Li, Ling Xu, Yi Xuan Zuo, Xue Qin Chang, Hai Tao Chi
Summary: Atherosclerosis is a chronic inflammatory disease of the blood vessels, characterized by the formation of atherosclerotic plaques and vascular endothelial injury. Ferroptosis, a form of cell death, and neuroinflammation have been shown to be involved in the progression of atherosclerosis. Understanding the underlying mechanisms and identifying new therapeutic targets are beneficial for preventing related diseases.
MOLECULAR MEDICINE REPORTS
(2022)
Review
Cell Biology
Yanlong Leng, Xing Luo, Jiaying Yu, Haibo Jia, Bo Yu
Summary: This article provides an overview of the mechanism of ferroptosis and its specific role in cardiovascular disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Kai Chen, Xiaobing Jiang, Moxin Wu, Xianming Cao, Wendai Bao, Ling-Qiang Zhu
Summary: Ferroptosis is considered as a distinct mechanism in the pathogenesis of Alzheimer's disease, with involvement in key features of AD pathology. Inhibitors of ferroptosis show potential clinical benefits in both AD patients and mice models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Zhen Chen, Weilong Wang, Siti Razila Abdul Razak, Tao Han, Nor Hazwani Ahmad, Xiumin Li
Summary: This review summarizes the key pathways of ferroptosis, discusses its dual role as an oncogenic factor and a tumor suppressor in human cancers, and presents multiple pharmacological activators of ferroptosis. The potential of targeting ferroptosis in cancer therapy is also discussed.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Keiko Hosohata, Tanisorn Harnsirikarn, Susama Chokesuwattanaskul
Summary: This review summarizes the involvement and importance of ferroptosis in acute kidney injury through oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Hanshu Yuan, Justin Pratte, Charles Giardina
Summary: Ferroptosis is a recently defined form of programmed cell death that is distinct due to its iron dependency and accumulation of lipid hydroperoxides. It can be regulated by various cellular variables and is potentially linked to degenerative diseases and acute injury scenarios. Additionally, ferroptosis may have significance in tumor-suppression and cancer therapy as a proposed target.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Izadora de Souza, Maria Carolina Clares Ramalho, Camila Banca Guedes, Isabeli Yumi Araujo Osawa, Linda Karolynne Seregni Monteiro, Luciana Rodrigues Gomes, Clarissa Ribeiro Reily Rocha
Summary: Glioblastoma multiforme is a lethal disease characterized by drug resistance and evasion of cell death. Ferroptosis, a recently described type of cell death, holds potential as a promising approach for glioblastoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Lu-Ping Zhou, Ren-Jie Zhang, Chong-Yu Jia, Liang Kang, Zhi-Gang Zhang, Hua-Qing Zhang, Jia-Qi Wang, Bo Zhang, Cai-Liang Shen
Summary: Ferroptosis is an iron-dependent form of programmed cell death that is regulated by various cellular metabolic pathways. It plays a significant role in multiple diseases and has become a new therapeutic target for intervertebral disc degeneration (IVDD) treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Qing Li, Zhigiang Zhao, Xia Zhou, Yuting Yan, Lusi Shi, Jiafan Chen, Baohui Fu, Jingyuan Mao
Summary: This review explains the possible correlations between HFpEF and ferroptosis and provides a reliable theoretical basis for future studies on its mechanism.
Review
Geriatrics & Gerontology
Jie Ju, Ya-nan Song, Kun Wang
Summary: Ferroptosis is a form of programmed cell death triggered by oxidative stress and iron dysregulation, with various proteins and molecules playing regulatory roles. It is involved in pathogen infection, tumor immunology, and cardiovascular diseases, suggesting its potential as a therapeutic target for CVDs.
Review
Medical Laboratory Technology
Li Zhou, Jun-Yi Li, Ping-Ping He, Xiao-Hua Yu, Chao-Ke Tang
Summary: Resistin plays pleiotropic roles in humans by targeting receptors TLR4 and CAP1, triggering intracellular signal transduction pathways and inducing vascular inflammation, leading to damages to cardiovascular system. It is highlighted as a potential therapeutic or diagnostic target for cardiovascular disease.
CLINICA CHIMICA ACTA
(2021)
Review
Cell Biology
Yuqin Wang, Yajie Zhao, Ting Ye, Liming Yang, Yanna Shen, Hong Li
Summary: Atherosclerosis (AS) is a major cause of cardiovascular diseases, while ferroptosis has been shown to play a crucial role in the development and progression of AS. The NRF2-Keap1 pathway reduces ferroptosis associated with AS by maintaining iron homeostasis. p53 and the Hippo pathway have important functions in different stages and progression of AS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Mingyu Yang, Meng Li, Zhuozhen Lyu, Zhen Yang
Summary: Cholangiocarcinoma, the second most common liver neoplasm, has a low 5-year survival rate. Understanding the role of iron-dependent cell death (ferroptosis) and inflammation in its progression is crucial. Cancer cells are addicted to iron, which is essential for their high metabolic demands. Exploring the mechanism of ferroptosis in cholangiocarcinoma development and developing pro-ferroptotic treatments could be promising for future therapies.
CANCER MANAGEMENT AND RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
D. Vitalakumar, Ankita Sharma, Swaran J. S. Flora
Summary: Ferroptosis is a newly identified form of regulated cell death that plays a major role in neurodegenerative diseases, regulated mainly through iron homeostasis, glutathione metabolism, and lipid peroxidation. Studies targeting ferroptosis in PD and AD have shown positive results, suggesting a promising target for treating neurodegenerative diseases. Ongoing research in the brain on ferroptosis provides new insights into understanding the pathogenesis of neurodegenerative diseases.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chang Li, Xunzhe Yin, Zuojia Liu, Jin Wang
Summary: This article reviews recent research on the mechanisms of ferroptosis in PDAC, explores the association between ferroptosis and the KRAS target in PDAC, and summarizes several potential strategies that can trigger ferroptosis to suppress PDAC progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)