Review
Endocrinology & Metabolism
Xi-Ding Yang, Yong-Yu Yang
Summary: This review summarizes the role and regulatory mechanisms of ferroptosis in diabetes and its complications, as well as the inhibitors of ferroptosis in diabetes and diabetic complications. Understanding the regulation of ferroptosis and developing drugs targeting ferroptosis may provide new treatment strategies for patients with diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Kai Chen, Xiaobing Jiang, Moxin Wu, Xianming Cao, Wendai Bao, Ling-Qiang Zhu
Summary: Ferroptosis is considered as a distinct mechanism in the pathogenesis of Alzheimer's disease, with involvement in key features of AD pathology. Inhibitors of ferroptosis show potential clinical benefits in both AD patients and mice models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Keiko Hosohata, Tanisorn Harnsirikarn, Susama Chokesuwattanaskul
Summary: This review summarizes the involvement and importance of ferroptosis in acute kidney injury through oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Qian Deng, Yue Zhu, Mengmeng Zhang, Aihua Fei, Jiaqi Liang, Jinjin Zheng, Qingping Zhang, Tong Cheng, Xia Ge
Summary: Diabetes, a complex metabolic disease, has become a global health concern in recent years. Finding promising therapeutic targets and directions is crucial. Ferroptosis, a new type of programmed cell death characterized by iron-dependent lipid peroxidation, has been shown to play an important regulatory role in the initiation and development of diabetes and its complications. This review summarizes new findings related to ferroptosis and diabetic complications and proposes ferroptosis as a potential target for treating diabetic complications.
ENDOCRINE CONNECTIONS
(2023)
Review
Biochemistry & Molecular Biology
Izadora de Souza, Maria Carolina Clares Ramalho, Camila Banca Guedes, Isabeli Yumi Araujo Osawa, Linda Karolynne Seregni Monteiro, Luciana Rodrigues Gomes, Clarissa Ribeiro Reily Rocha
Summary: Glioblastoma multiforme is a lethal disease characterized by drug resistance and evasion of cell death. Ferroptosis, a recently described type of cell death, holds potential as a promising approach for glioblastoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Xiaoguang Wu, Yi Li, Shuchen Zhang, Xiang Zhou
Summary: Cell death is a significant factor in cardiovascular disease pathophysiology. Ferroptosis, a regulated cell death form characterized by iron overload and lipid hydroperoxide accumulation, is closely associated with various diseases and plays critical roles in cardiomyopathy, myocardial infarction, ischemia/reperfusion injury, and heart failure. Targeting ferroptosis may offer potential novel therapeutic strategies for cardiovascular diseases.
Review
Environmental Sciences
Wenli Ding, Luxi Lin, Ke Yue, Yanfeng He, Bowen Xu, Aftab Shaukat, Shucheng Huang
Summary: Mycotoxin contamination poses a significant threat to food safety and human health. Understanding the mechanism of mycotoxin toxicity is crucial for detoxification. Ferroptosis, characterized by iron overload and accumulation of lipid reactive oxygen species (ROS) and depletion of glutathione (GSH), plays a role in organ damage from mycotoxin exposure, and natural antioxidants can alleviate mycotoxicosis and regulate ferroptosis. Chinese herbal medicine research on treating diseases through ferroptosis has gained attention. This article reviews the mechanism of ferroptosis, discusses its role in mycotoxicosis, and summarizes the current status of Chinese herbal interventions in regulating mycotoxicosis through ferroptosis, providing insights for future treatment strategies.
Review
Cell Biology
Zhen Chen, Weilong Wang, Siti Razila Abdul Razak, Tao Han, Nor Hazwani Ahmad, Xiumin Li
Summary: This review summarizes the key pathways of ferroptosis, discusses its dual role as an oncogenic factor and a tumor suppressor in human cancers, and presents multiple pharmacological activators of ferroptosis. The potential of targeting ferroptosis in cancer therapy is also discussed.
CELL DEATH & DISEASE
(2023)
Review
Pharmacology & Pharmacy
Xiaoli Zhang, Yiming Ma, Guoqing Lv, Hongying Wang
Summary: Ferroptosis is a type of programmed cell death that depends on iron and is characterized by lipid peroxidation induced by reactive oxygen species and resulting membrane damage. Recent research has revealed its mechanism and explored its connection to various diseases, including degenerative diseases, cancer, and inflammation. Inflammation-related intestinal diseases such as colitis and colitis-associated cancer are associated with ferroptosis. Understanding the role of ferroptosis in the pathogenesis of these diseases has led to the identification of potential therapeutic targets. This review summarizes the current knowledge on the molecular mechanisms of ferroptosis and discusses its emerging role and therapeutic potential in inflammation-related intestinal diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
D. Vitalakumar, Ankita Sharma, Swaran J. S. Flora
Summary: Ferroptosis is a newly identified form of regulated cell death that plays a major role in neurodegenerative diseases, regulated mainly through iron homeostasis, glutathione metabolism, and lipid peroxidation. Studies targeting ferroptosis in PD and AD have shown positive results, suggesting a promising target for treating neurodegenerative diseases. Ongoing research in the brain on ferroptosis provides new insights into understanding the pathogenesis of neurodegenerative diseases.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Review
Cell Biology
Zhenyu Zhai, Pengtao Zou, Fuxiang Liu, Zirong Xia, Juxiang Li
Summary: Ferroptosis, a recently discovered iron-dependent programmed cell death pathway, plays a significant role in cardiovascular diseases. Research has shown that blocking the ferroptosis pathways can alleviate myocardial injury. Therefore, ferroptosis may be a novel diagnostic and therapeutic target for patients suffering from cardiomyopathy in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yuzhen Lu, Junjie Hu, Liang Chen, Shan Li, Ming Yuan, Xianxiang Tian, Peng Cao, Zhenpeng Qiu
Summary: Ferroptosis is a nonapoptotic cell death characterized by excessive accumulation of lipid peroxides and disturbances in cellular iron metabolism, which plays a role in the pathogenesis of liver diseases. The liver, as a major metabolic hub, is involved in the synthesis and transport of plasma proteins and fatty acids, as well as iron storage. Pharmacological induction and inhibition of ferroptosis have potential therapeutic effects in hepatic disorders associated with lipid peroxidation. This review outlines the features, molecular mechanisms, and modulatory networks of ferroptosis in liver diseases, and summarizes the mechanisms by which ferroptosis inducers and inhibitors improve liver diseases. Natual active ingredients show efficacy in regulating ferroptosis in preclinical liver disease models.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chang Li, Xunzhe Yin, Zuojia Liu, Jin Wang
Summary: This article reviews recent research on the mechanisms of ferroptosis in PDAC, explores the association between ferroptosis and the KRAS target in PDAC, and summarizes several potential strategies that can trigger ferroptosis to suppress PDAC progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Le Li, Zhijun Zhu
Summary: Liver fibrosis is an abnormal repair reaction and pathological outcome of chronic liver diseases, and recent studies have found that ferroptosis contributes to its development. Therapeutic agents inducing hepatic stellate cell (HSCs) ferroptosis have shown effectiveness in experimental liver fibrosis models. This review focuses on the mechanism of ferroptosis in liver fibrosis and summarizes the pharmacological effectiveness of different therapeutic agents for its treatment. HSCs ferroptosis may be a potential target for novel therapies against liver fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Yunqing Chen, Yan Xu, Kan Zhang, Liang Shen, Min Deng
Summary: This review discusses the pathological changes in liver injury caused by COVID-19 and proposes ferroptosis as a potential mechanism. The therapeutic potential of targeting ferroptosis in COVID-19-related liver injury is also examined. Advancements in these areas will enhance our understanding of strategies to prevent and treat COVID-19-induced hepatic injuries.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)