Regeneration, Rejuvenation, and Replacement: Turning Back the Clock on Tissue Aging

A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis

(2021) Bo Shen et al.   NATURE

Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration

(2020) John V. Pluvinage et al.   NATURE REVIEWS NEUROSCIENCE

Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells

(2020) Tapash Jay Sarkar et al.   Nature Communications

Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues

(2020) Matthew J. Yousefzadeh et al.   GeroScience

Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?

(2020) Hannah J. Smith et al.   DEVELOPMENTAL CELL

Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain

(2020) Alana M. Horowitz et al.   SCIENCE

Candidate rejuvenating factor GDF11 and tissue fibrosis: friend or foe?

(2020) Jan Frohlich et al.   GeroScience

Reprogramming to recover youthful epigenetic information and restore vision

(2020) Yuancheng Lu et al.   NATURE

Nutritional Control of Intestinal Stem Cells in Homeostasis and Tumorigenesis

(2020) Gizem Calibasi-Kocal et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

(2019) Elena P. Moreno-Jiménez et al.   NATURE MEDICINE

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients

(2019) Matthew K. Tobin et al.   Cell Stem Cell

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

(2018) Maria M. Mihaylova et al.   Cell Stem Cell

Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells

(2018) Maryam Yousefi et al.   Stem Cell Reports

Does Adult Neurogenesis Persist in the Human Hippocampus?

(2018) Mercedes F. Paredes et al.   Cell Stem Cell

Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster

(2018) Kazutaka Akagi et al.   PLoS Genetics

Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study

(2018) Sharon J. Sha et al.   JAMA Neurology

Satellite cell activation induced by aerobic muscle adaptation in response to endurance exercise in humans and rodents

(2017) Phablo Abreu et al.   LIFE SCIENCES

CCL11 promotes migration and proliferation of mouse neural progenitor cells

(2017) Feifei Wang et al.   Stem Cell Research & Therapy

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction

(2016) Masaki Igarashi et al.   CELL

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

(2016) Valter D. Longo et al.   Cell Metabolism

Satellite cell depletion prevents fiber hypertrophy in skeletal muscle

(2016) Ingrid M. Egner et al.   DEVELOPMENT

Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging

(2016) Duozhuang Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

(2016) Justin Rebo et al.   Nature Communications

Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

(2016) Jennifer C Regan et al.   eLife

GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration

(2015) Marc A. Egerman et al.   Cell Metabolism

Reduced Circulating GDF11 Is Unlikely Responsible for Age-Dependent Changes in Mouse Heart, Muscle, and Brain

(2015) Buel D. Rodgers et al.   ENDOCRINOLOGY

β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis

(2015) Lucas K Smith et al.   NATURE MEDICINE

Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival

(2015) Kelsey L. Tinkum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cells and healthy aging

(2015) M. A. Goodell et al.   SCIENCE

Erratum: Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin

(2015) Gurpreet S. Baht et al.   Nature Communications

Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status

(2015) Camilla A. Richmond et al.   Cell Reports

Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

(2014) Chia-Wei Cheng et al.   Cell Stem Cell

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity

(2013) Michael J. Conboy et al.   AGING CELL

Reprogramming in vivo produces teratomas and iPS cells with totipotency features

(2013) María Abad et al.   NATURE

Early Activation of Rat Skeletal Muscle IL-6/STAT1/STAT3 Dependent Gene Expression in Resistance Exercise Linked to Hypertrophy

(2013) Gwénaëlle Begue et al.   PLoS One

Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing

(2012) A. V. Ergen et al.   BLOOD

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

(2012) Atsuhiko T. Naito et al.   CELL

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

(2012) Thomas A. Rando et al.   CELL

Rejuvenation of Regeneration in the Aging Central Nervous System

(2012) Julia M. Ruckh et al.   Cell Stem Cell

The let-7–Imp axis regulates ageing of the Drosophila testis stem-cell niche

(2012) Hila Toledano et al.   NATURE

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

(2012) Ömer H. Yilmaz et al.   NATURE

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

(2012) M. Rera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Satellite cell pool enhancement in rat plantaris muscle by endurance training depends on intensity rather than duration

(2011) M. Kurosaka et al.   Acta Physiologica

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Emerging models and paradigms for stem cell ageing

(2011) D. Leanne Jones et al.   NATURE CELL BIOLOGY

Dietary restriction enhances germline stem cell maintenance

(2010) William Mair et al.   AGING CELL

Metabolic Regulation of Stem Cell Behavior and Implications for Aging

(2010) Heinrich Jasper et al.   Cell Metabolism

Stem Cells and the Niche: A Dynamic Duo

(2010) Justin Voog et al.   Cell Stem Cell

Stem Cell Dynamics in Response to Nutrient Availability

(2010) Catherine J. McLeod et al.   CURRENT BIOLOGY

Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila

(2010) Benoît Biteau et al.   PLoS Genetics

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor

(2008) Na-Hyun Choi et al.   AGING CELL

Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction

(2008) William Mair et al.   Annual Review of Biochemistry

JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut

(2008) Benoît Biteau et al.   Cell Stem Cell

Exercise-induced attenuation of obesity, hyperinsulinemia, and skeletal muscle lipid peroxidation in the OLETF rat

(2007) R. Tyler Morris et al.   JOURNAL OF APPLIED PHYSIOLOGY