Drug discovery in the era of cryo-electron microscopy

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

(2021) Goran Kokic et al.   Nature Communications

Structure of the transcription coactivator SAGA

(2020) Haibo Wang et al.   NATURE

Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc

(2020) Dean P. Staus et al.   NATURE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab

(2020) Lionel Rougé et al.   SCIENCE

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

(2020) Dora Pinto et al.   NATURE

Cryo-EM structures from sub-nl volumes using pin-printing and jet vitrification

(2020) Raimond B. G. Ravelli et al.   Nature Communications

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

(2020) Lihong Liu et al.   NATURE

Time-resolved cryo-EM using Spotiton

(2020) Venkata P. Dandey et al.   NATURE METHODS

Cryo-EM analysis of a membrane protein embedded in the liposome

(2020) Xia Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

(2020) Xiangyang Chi et al.   SCIENCE

GemSpot: A Pipeline for Robust Modeling of Ligands into Cryo-EM Maps

(2020) Michael J. Robertson et al.   STRUCTURE

Modular microfluidics enables kinetic insight from time-resolved cryo-EM

(2020) Märt-Erik Mäeots et al.   Nature Communications

Crystal structure of the human oxytocin receptor

(2020) Yann Waltenspühl et al.   Science Advances

Single-particle cryo-EM at atomic resolution

(2020) Takanori Nakane et al.   NATURE

Atomic-resolution protein structure determination by cryo-EM

(2020) Ka Man Yip et al.   NATURE

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Binding mechanisms of therapeutic antibodies to human CD20

(2020) Anand Kumar et al.   SCIENCE

Need for Speed: Examining Protein Behavior during CryoEM Grid Preparation at Different Timescales

(2020) David P. Klebl et al.   STRUCTURE

Small-molecule inhibitors of human mitochondrial DNA transcription

(2020) Nina A. Bonekamp et al.   NATURE

Structural insight into substrate and inhibitor discrimination by human P-glycoprotein

(2019) Amer Alam et al.   SCIENCE

Structural insight into TRPV5 channel function and modulation

(2019) Shangyu Dang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-Electron Microscopy Methodology: Current Aspects and Future Directions

(2019) Radostin Danev et al.   TRENDS IN BIOCHEMICAL SCIENCES

Conformational transitions of a neurotensin receptor 1–Gi1 complex

(2019) Hideaki E. Kato et al.   NATURE

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex

(2019) Emiko Uchikawa et al.   eLife

The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1

(2019) Siew Siew Pang et al.   Nature Communications

CryoEM at 100 keV: a demonstration and prospects

(2019) K. Naydenova et al.   IUCrJ

Fragment-based drug discovery using cryo-EM

(2019) Michael Saur et al.   DRUG DISCOVERY TODAY

Cryo-electron microscopy of membrane proteins

(2018) Nopnithi Thonghin et al.   METHODS

Cryo-EM in drug discovery: achievements, limitations and prospects

(2018) Jean-Paul Renaud et al.   NATURE REVIEWS DRUG DISCOVERY

Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION

(2018) Takanori Nakane et al.   eLife

Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex

(2018) Qianhui Qu et al.   CELL

Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis

(2018) Giovanna Scapin et al.   NATURE

Reducing effects of particle adsorption to the air–water interface in cryo-EM

(2018) Alex J. Noble et al.   NATURE METHODS

GABAA receptor signalling mechanisms revealed by structural pharmacology

(2018) Simonas Masiulis et al.   NATURE

Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

(2017) Timothy P.S. Perera et al.   MOLECULAR CANCER THERAPEUTICS

Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin

(2017) Moran Shalev-Benami et al.   Nature Communications

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

(2016) Yong Jia et al.   NATURE

Discovery of Chemical Inhibitors of Human Bromodomains

(2015) Guangtao Zhang et al.   CHEMICAL REVIEWS

The discovery of first-in-class drugs: origins and evolution

(2014) Jörg Eder et al.   NATURE REVIEWS DRUG DISCOVERY

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

(2013) Jonathan M. Ostrem et al.   NATURE

Activation and allosteric modulation of a muscarinic acetylcholine receptor

(2013) Andrew C. Kruse et al.   NATURE

Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator

(2013) Shifeng Pan et al.   ACS Medicinal Chemistry Letters

New target for inhibition of bacterial RNA polymerase: ‘switch region’

(2011) Aashish Srivastava et al.   CURRENT OPINION IN MICROBIOLOGY

A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives

(2010) Nicholas A. McGrath et al.   JOURNAL OF CHEMICAL EDUCATION

Structure-Based Design, Synthesis, and Structure−Activity Relationship Studies of HIV-1 Protease Inhibitors Incorporating Phenyloxazolidinones

(2010) Akbar Ali et al.   JOURNAL OF MEDICINAL CHEMISTRY

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY