Visible-light induced direct C-H difluoromethylation of quinoxalin-2(1H)-ones by [bis(difluoroacetoxy)iodo]benzene under catalysis-free conditions

CF3SO2Na Acted as a Bifunctional Reagent: Electrochemical Trifluoromethylation of Alkenes Accompanied by SO2-Insertion to Access Trifluoromethylated Cyclic N-Sulfonylimines

(2020) Wei-Wei Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

From C1 to C3: Copper-Catalyzed gem-Bis(trifluoromethyl)olefination of α-Diazo Esters with TMSCF3

(2020) Jinbo Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NHC-Catalyzed Radical Trifluoromethylation Enabled by Togni Reagent

(2020) Bei Zhang et al.   ORGANIC LETTERS

Electrochemical Intramolecular Oxytrifluoromethylation of N-Tethered Alkenyl Alcohols: Synthesis of Functionalized Morpholines

(2020) Aurélie Claraz et al.   ORGANIC LETTERS

Intermolecular Trifluoromethyl-Hydrazination of Alkenes Enabled by Organic Photoredox Catalysis

(2020) Peng Wang et al.   ORGANIC LETTERS

Cu-Catalyzed Site-Selective C(sp2)–H Radical Trifluoromethylation of Tryptophan-Containing Peptides

(2020) Itziar Guerrero et al.   ORGANIC LETTERS

Direct C–H difluoromethylation of heterocycles via organic photoredox catalysis

(2020) Wei Zhang et al.   Nature Communications

Trifluoromethylation of Alkyl Radicals: Breakthrough and Challenges †

(2020) Lin Zhu et al.   CHINESE JOURNAL OF CHEMISTRY

The merger of decatungstate and copper catalysis to enable aliphatic C(sp3)–H trifluoromethylation

(2020) Patrick J. Sarver et al.   Nature Chemistry

Copper-Catalyzed Trifluoromethylation of Ynones Coupled with Dearomatizing Spirocyclization of Indoles: Access to CF3-Containing Spiro[cyclopentane-1,3′-indole]

(2020) Chengwen Li et al.   ORGANIC LETTERS

Access to Aryl and Heteroaryl Trifluoromethyl Ketones from Aryl Bromides and Fluorosulfates with Stoichiometric CO

(2020) Martin B. Johansen et al.   ORGANIC LETTERS

AIBN-Induced Remote Trifluoromethyl-Alkynylation of Thioalkynes

(2020) Zhimin Xiong et al.   ORGANIC LETTERS

Silver‐Enabled General Radical Difluoromethylation Reaction with TMSCF 2 H

(2020) Jun Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal-free C3-alkoxycarbonylation of quinoxalin-2(1H)-ones with carbazates as ecofriendly ester sources

(2019) Long-Yong Xie et al.   Science China-Chemistry

Iminyl Radical-Triggered Intermolecular Distal C(sp3)–H Heteroarylation via 1,5-Hydrogen-Atom Transfer (HAT) Cascade

(2019) Yu-Rui Gu et al.   ORGANIC LETTERS

Direct C(sp 2 )−H Amination to Synthesize Primary 3-aminoquinoxalin-2(1H )-ones under Simple and Mild Conditions

(2019) Qiming Yang et al.   ADVANCED SYNTHESIS & CATALYSIS

Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid

(2019) Claudio F. Meyer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible Light‐Induced Regioselective Decarboxylative Alkylation of the C( sp 2 )−H Bonds of Non‐Aromatic Heterocycles

(2019) Lixin Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Transition-Metal and Solvent-Free Oxidative C–H Fluoroalkoxylation of Quinoxalinones with Fluoroalkyl Alcohols

(2019) Jun Xu et al.   ORGANIC LETTERS

Visible‐Light‐Induced Alkoxylation of Quinoxalin‐2(1 H )‐ones with Alcohols for the Synthesis of Heteroaryl Ethers

(2019) Lulu Zhao et al.   ADVANCED SYNTHESIS & CATALYSIS

Direct C3 Alkoxylation of Quinoxalin-2(1H)-ones with Alcohols via Cross-Dehydrogenative Coupling under Catalyst-Free Conditions

(2019) Qiming Yang et al.   JOURNAL OF ORGANIC CHEMISTRY

Recent Developments in Direct C–H Functionalization of Quinoxalin-2(1H)-ones via Radical Addition Processes

(2019) Monika Monika et al.   SYNTHESIS-STUTTGART

Electrophotocatalytic Undirected C−H Trifluoromethylations of (Het)Arenes

(2019) Youai Qiu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-catalyzed Direct C-3 Benzylation of Quinoxalin-2(1H)-ones with Methylarenes under Microwave Irradiation

(2018) Leqian Hu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Quinoxalinone as a Privileged Platform in Drug Development

(2018) Leilei Shi et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Metal-free oxidative coupling of quinoxalin-2(1H)-ones with arylaldehydes leading to 3-acylated quinoxalin-2(1H)-ones

(2018) Jin-Wei Yuan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Persulfate-promoted oxidative C–N bond coupling of quinoxalinones and NH-sulfoximines

(2018) Ladawan Sumunnee et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Direct C–H Cyanoalkylation of Quinoxalin-2(1H)-ones via Radical C–C Bond Cleavage

(2018) Lin Yang et al.   ORGANIC LETTERS

Visible-Light Photoredox Decarboxylation of Perfluoroarene Iodine(III) Trifluoroacetates for C–H Trifluoromethylation of (Hetero)arenes

(2018) Bin Yang et al.   ACS Catalysis

Direct C−H Trifluoromethylation of Quinoxalin-2(1H )-ones under Transition-Metal-Free Conditions

(2018) Liping Wang et al.   ADVANCED SYNTHESIS & CATALYSIS

Transition-Metal-Free Decarboxylation of 3,3,3-Trifluoro-2,2-dimethylpropanoic Acid for the Preparation of C(CF3)Me2-Containing Heteroarenes

(2018) Shuai Liu et al.   ORGANIC LETTERS

Transition-metal-free direct C-3 alkylation of quinoxalin-2(1H)-ones with ethers

(2018) Jinwei Yuan et al.   Organic Chemistry Frontiers

[3+2] Cyclization of Azidotrimethylsilane with Quinoxalin-2(1H )-Ones to Synthesize Tetrazolo[1,5-a ]quinoxalin-4(5H )-Ones

(2018) Qiming Yang et al.   ADVANCED SYNTHESIS & CATALYSIS

Competing Crystallization between Lanthanide and Actinide in Acidic Solution Leading to Their Efficient Separation

(2018) Xuemiao Yin et al.   CHINESE JOURNAL OF CHEMISTRY

Visible-Light- and Oxygen-Promoted Direct Csp2-H Radical Difluoromethylation of Coumarins and Antifungal Activities

(2018) Peng Dai et al.   ORGANIC LETTERS

Metal-Free C(sp2)–H/N–H Cross-Dehydrogenative Coupling of Quinoxalinones with Aliphatic Amines under Visible-Light Photoredox Catalysis

(2018) Wei Wei et al.   ORGANIC LETTERS

Silver-catalyzed fluoroalkylation of thiols using fluoroalkanesulfinates

(2017) Jing-jing Ma et al.   JOURNAL OF FLUORINE CHEMISTRY

Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept

(2017) Yossi Zafrani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iodine-Catalyzed C–N Bond Formation: Synthesis of 3-Aminoquinoxalinones under Ambient Conditions

(2017) Abhishek Gupta et al.   JOURNAL OF ORGANIC CHEMISTRY

CF2H, a Hydrogen Bond Donor

(2017) Chanan D. Sessler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver-catalyzed decarboxylative acylation of quinoxalin-2(1H)-ones with α-oxo-carboxylic acids

(2017) Xiaobao Zeng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Transition-Metal-Free Direct C–H Arylation of Quinoxalin-2(1H)-ones with Diaryliodonium Salts at Room Temperature

(2017) Kun Yin et al.   ORGANIC LETTERS

The Direct C–H Difluoromethylation of Heteroarenes Based on the Photolysis of Hypervalent Iodine(III) Reagents That Contain Difluoroacetoxy Ligands

(2017) Ryu Sakamoto et al.   ORGANIC LETTERS

China's flourishing synthetic organofluorine chemistry: innovations in the new millennium

(2017) Qinghe Liu et al.   National Science Review

Radical Fluoroalkylation of Isocyanides with Fluorinated Sulfones by Visible-Light Photoredox Catalysis

(2016) Jian Rong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-light-mediated radical oxydifluoromethylation of olefinic amides for the synthesis of CF2H-containing heterocycles

(2016) Weijun Fu et al.   CHEMICAL COMMUNICATIONS

Direct phosphonation of quinoxalin-2(1H)-ones under transition-metal-free conditions

(2016) Ming Gao et al.   CHEMICAL COMMUNICATIONS

Methyl fluorosulfonyldifluoroacetate (MFSDA): An Underutilised Reagent for Trifluoromethylation

(2016) Sarah L. Clarke et al.   CHEMISTRY-A EUROPEAN JOURNAL

Visible Light Induced Oxydifluoromethylation of Styrenes with Difluoromethyltriphenylphosphonium Bromide

(2016) Yang Ran et al.   JOURNAL OF ORGANIC CHEMISTRY

Photoredox-Catalyzed Intramolecular Difluoromethylation of N-Benzylacrylamides Coupled with a Dearomatizing Spirocyclization: Access to CF2H-Containing 2-Azaspiro[4.5]deca-6,9-diene-3,8-diones

(2016) Zuxiao Zhang et al.   ORGANIC LETTERS

Visible-Light-Induced Hydrodifluoromethylation of Alkenes with a Bromodifluoromethylphosphonium Bromide

(2015) Qing-Yu Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient Cu-catalyzed Atom Transfer Radical Addition Reactions of Fluoroalkylsulfonyl Chlorides with Electron-deficient Alkenes Induced by Visible Light

(2015) Xiao-Jun Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Photoredox-Catalyzed Reductive Difluoromethylation of Electron-Deficient Alkenes

(2015) Xiao-Jun Tang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oxydifluoromethylation of Alkenes by Photoredox Catalysis: Simple Synthesis of CF2 H-Containing Alcohols

(2015) Yusuke Arai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Quinoxaline, its derivatives and applications: A State of the Art review

(2015) Joana A. Pereira et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fluoroalkylative Aryl Migration of Conjugated N-Arylsulfonylated Amides Using Easily Accessible Sodium Di- and Monofluoroalkanesulfinates

(2015) Zhengbiao He et al.   ORGANIC LETTERS

Photoredox-Catalyzed Intramolecular Aminodifluoromethylation of Unactivated Alkenes

(2015) Zuxiao Zhang et al.   ORGANIC LETTERS

Photoredox-Catalyzed Tandem Insertion/Cyclization Reactions of Difluoromethyl and 1,1-Difluoroalkyl Radicals with Biphenyl Isocyanides

(2015) Zuxiao Zhang et al.   ORGANIC LETTERS

Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents

(2014) Julie Charpentier et al.   CHEMICAL REVIEWS

Recent Advances in Trifluoromethylation Reactions with Electrophilic Trifluoromethylating Reagents

(2014) Sebastián Barata-Vallejo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Introduction of Fluorine and Fluorine-Containing Functional Groups

(2013) Theresa Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Palladium(II)-Catalyzed Oxidative Arylation of Quinoxalin-2(1H)-ones with Arylboronic Acids

(2013) Amandine Carrër et al.   ORGANIC LETTERS

Copper- and Iron-Catalyzed Decarboxylative Tri- and Difluoromethylation of α,β-Unsaturated Carboxylic Acids with CF3SO2Na and (CF2HSO2)2Zn via a Radical Process

(2013) Zejiang Li et al.   ORGANIC LETTERS

A “Renaissance” in Radical Trifluoromethylation

(2012) Armido Studer   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A New Reagent for Direct Difluoromethylation

(2012) Yuta Fujiwara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical and innate carbon–hydrogen functionalization of heterocycles

(2012) Yuta Fujiwara et al.   NATURE

A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells

(2012) Michel Weïwer et al.   ACS Medicinal Chemistry Letters

Aromatic Trifluoromethylation with Metal Complexes

(2011) Olesya A. Tomashenko et al.   CHEMICAL REVIEWS

The fluorous effect in biomolecular applications

(2011) Massimo Cametti et al.   CHEMICAL SOCIETY REVIEWS

An Efficient Domino Synthesis of Quinoxalin-2(1H)-ones via an SNAr/Coupling/Demesylation Reaction Catalyzed by Copper(I) as Key Step

(2010) Dingben Chen et al.   ADVANCED SYNTHESIS & CATALYSIS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS