Review
Immunology
Yaoyao Xia, Yikun Li, Xiaoyan Wu, Qingzhuo Zhang, Siyuan Chen, Xianyong Ma, Miao Yu
Summary: The review highlights the crucial role of iron in dictating macrophage polarization by orchestrating various aspects such as cellular signaling, cellular metabolism, and epigenetic regulation. Iron modulation affects the development and progression of multiple macrophage-associated diseases, suggesting the potential application of iron supplementation in adjuvant therapy for different inflammatory disorders relative to macrophage polarization balance.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Yanhui Hao, Leilei Yang, Ying Liu, Yumeng Ye, Jiayu Wang, Chao Yu, Hua Yan, Yuan Xing, Zhaoqian Jia, Cuicui Hu, Hongyan Zuo, Yang Li
Summary: The study identified miR-145a-5p as a potential regulator in diabetic wound healing, with downregulated expression during tissue formation and inhibitory effect on M1 macrophage polarization while promoting M2 phenotype activation. Administration of miR-145a-5p mimics significantly accelerated wound healing in diabetic mice.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
William J. Melvin, Christopher O. Audu, Frank M. Davis, Sriganesh B. Sharma, Amrita Joshi, Aaron DenDekker, Sonya Wolf, Emily Barrett, Kevin Mangum, Xiaofeng Zhou, Monica Bame, Alex Ruan, Andrea Obi, Steven L. Kunkel, Bethany B. Moore, Katherine A. Gallagher
Summary: COVID-19 induces a strong inflammatory response, particularly in patients with type 2 diabetes. Research has shown that coronavirus infection decreases the level of histone methyltransferase, contributing to increased inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Kevin Mangum, Katherine Gallagher, Frank M. Davis
Summary: Abdominal aortic aneurysm (AAA) is a life-threatening disease with a lack of pharmaceutical treatment options. Previous studies have shown that epigenetic modifications play a crucial regulatory role in the development of AAA. This review discusses the roles and significance of epigenetic modifications in AAA animal models and their relevance to human pathology.
Article
Biochemistry & Molecular Biology
Chih-Hsing Hung, Yi-Ching Lin, Yi-Giien Tsai, Yu-Chih Lin, Chia-Hong Kuo, Mei-Lan Tsai, Chao-Hung Kuo, Wei-Ting Liao
Summary: Acrylamide promoted mitochondria-specific ROS generation, increased gene expression of mitochondrial respiratory chain complex II SDHA, induced histone modifications and upregulated PINK1 expression, leading to a macrophage M2 polarization shift in THP-1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Paul Martin, David Baruch Gurevich
Summary: Macrophages, primarily known for their phagocytic functions, are highly dynamic multi-taskers that play regulatory roles in development, homeostasis, tissue repair, and disease. Recent studies focus on how macrophages regulate angiogenesis, blood vessel sprouting, and tissue remodelling in diverse models, such as rodents, fish, and tissue culture studies. These interactions and regulatory functions play a crucial role in embryonic tissue growth, wound repair, and pathologies like chronic wounds and cancer.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Changlong An, Baihai Jiao, Hao Du, Melanie Tran, Bo Song, Penghua Wang, Dong Zhou, Yanlin Wang
Summary: This study identifies JMJD3 as a critical regulator of myeloid fibroblast activation, macrophage polarization, and renal fibrosis development, suggesting it as a potential therapeutic target for chronic kidney disease.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ashley K. Putman, G. Andres Contreras
Summary: Dysregulated inflammation and oxidative stress play significant roles in various diseases. Macrophages are crucial in immune responses and regulate inflammation by exhibiting different phenotypes. IsoPs, as biomarkers of oxidative stress, can promote an anti-inflammatory macrophage phenotype during inflammation, contributing to disease prevention and mitigation.
Article
Biochemistry & Molecular Biology
Dalma Cricri, Lara Coppi, Silvia Pedretti, Nico Mitro, Donatella Caruso, Emma De Fabiani, Maurizio Crestani
Summary: Selective inhibition of class I HDACs, particularly HDAC3, improves adipocyte functionality, promotes browning phenotype, and enhances mitochondrial activity in adipocyte precursors. These effects are exerted early in differentiation process and involve modulation of gene expression related to metabolic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Yao Wan, Jiao Fang, Yu Wang, Jiao Sun, Yue Sun, Xiaolin Sun, Manlin Qi, Wen Li, Chunyan Li, Yanmin Zhou, Lin Xu, Biao Dong, Lin Wang
Summary: A strategy of introducing enzymatic activity into nanomaterials for antibacterial and anti-inflammatory effects is introduced, showing dual functionality for treating bacterial infected wounds. This simple metal organic framework design effectively combines the enzymatic activity of manganese ions with the pore structure advantages of ZIF-8.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Chelsea A. Kraynak, Wenbai Huang, Elizabeth C. Bender, Jie-Liang Wang, Mahmoud S. Hanafy, Zhengrong Cui, Laura J. Suggs
Summary: Chronic inflammation is an important pathological process in various diseases. Macrophages play a critical role in inflammation and can switch between pro-inflammatory and anti-inflammatory phenotypes. In this study, a nanoparticle was developed to target inflammation and reduce the inflammatory phenotype of macrophages by mimicking the anti-inflammatory effect of apoptotic cell engulfment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Immunology
Keizo Kohno, Satomi Koya-Miyata, Akira Harashima, Takahiko Tsukuda, Masataka Katakami, Toshio Ariyasu, Shimpei Ushio, Kanso Iwaki
Summary: The study demonstrates that NK-4 drives macrophage polarization towards an inflammatory M1-like phenotype and enhances phagocytic activity, playing a crucial role in resolving the inflammatory phase of wound healing.
JOURNAL OF INFLAMMATION-LONDON
(2021)
Article
Immunology
Xiumeng Hua, Mengni Bao, Han Mo, Zhe Sun, Mengda Xu, Xiao Chen, Xiuxue Mo, Gang Hu, Menghao Tao, Jiangping Song
Summary: This study found that STING is involved in the pathogenesis of autoimmune myocarditis by regulating the differentiation and activation of proinflammatory macrophages. STING activates proinflammatory macrophages via HIF1A, promoting the development of autoimmune myocarditis. This finding may provide a novel therapeutic target for autoimmune myocarditis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jun Li, Ruoshui Li, Izabela Tuleta, Silvia C. Hernandez, Claudio Humeres, Anis Hanna, Bijun Chen, Nikolaos G. Frangogiannis
Summary: The role of macrophage Smad7 in regulating inflammation and repair after myocardial infarction is limited. The anti-inflammatory effects of TGF-beta in macrophages are not restrained by endogenous Smad7 induction.
Review
Food Science & Technology
Lei Yan, Mostafa Vaghari-Tabari, Faezeh Malakoti, Soheila Moein, Durdi Qujeq, Bahman Yousefi, Zatollah Asemi
Summary: Various studies have shown that quercetin has beneficial therapeutic effects in various human diseases, including diabetes. Quercetin has significant anti-diabetic effects and may be helpful in lowering blood sugar and increasing insulin sensitivity. It also has positive effects in preventing and ameliorating diabetic complications, possibly due to its anti-inflammatory and anti-oxidant properties.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)