Article
Engineering, Environmental
Kai Wang, Ruonan Dong, Jiezhang Tang, Huichen Li, Juanli Dang, Zhaoxiang Zhang, Zhou Yu, Baolin Guo, Chenggang Yi
Summary: This study developed a self-healing hydrogel capable of stably releasing exosomes to enhance diabetic wound healing. Through the synergistic effect of exosome release and M2 macrophage polarization, it accelerated angiogenesis and wound healing.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Chi Yuan, Jian Liao, Liying Zheng, Lingzhi Ding, Xiao Teng, Xuesong Lin, Le Wang
Summary: This review examines the association between leptin and wound healing, speculating on the molecular mechanisms and the need for further research to understand its specific role in different phases of wound repair.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Yao Wan, Jiao Fang, Yu Wang, Jiao Sun, Yue Sun, Xiaolin Sun, Manlin Qi, Wen Li, Chunyan Li, Yanmin Zhou, Lin Xu, Biao Dong, Lin Wang
Summary: A strategy of introducing enzymatic activity into nanomaterials for antibacterial and anti-inflammatory effects is introduced, showing dual functionality for treating bacterial infected wounds. This simple metal organic framework design effectively combines the enzymatic activity of manganese ions with the pore structure advantages of ZIF-8.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Lifeng Zhang, Jiali Yang, Wencong Liu, Qiteng Ding, Shuwen Sun, Shuai Zhang, Ning Wang, Yue Wang, Siyu Xi, Chunyu Liu, Chuanbo Ding, Changtian Li
Summary: This study reported a hydrogel dressing (PCA) based on L-arginine conjugated chitosan (CA) and aldehyde functionalized polysaccharides of Phellinus igniarius (OPPI) for wound repair in diabetes. PCA showed good antioxidant, antibacterial, and safety properties, and effectively promoted wound healing by promoting epithelial formation, collagen deposition, and enhancing angiogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Chuan Guo, Yu Wang, Haoyang Song, Weilong Li, Qingquan Kong, Ye Wu
Summary: The study developed a pain reflex-inspired hydrogel that is responsive to the inflammatory microenvironment and can be used to promote the healing of chronically infected diabetic wounds. The intelligent hydrogel exhibited antibacterial, anti-inflammatory, and pro-angiogenic activity, and its reflexive behaviors make it ideal for facilitating wound healing in response to excessive local inflammation.
MATERIALS & DESIGN
(2022)
Review
Immunology
Meirong Li, Qian Hou, Lingzhi Zhong, Yali Zhao, Xiaobing Fu
Summary: The review highlights the persistent hyper-inflammation as a distinguishing characteristic of chronic wounds, with macrophage malfunction identified as a major contributor. The study explores the origin, heterogeneity, and dysregulation of macrophages in wound healing, while also evaluating therapeutic approaches for restoring macrophage response. Multidimensional analysis using high-throughput technologies helps assess the diversity, activation states, and communication of macrophages in healing and non-healing wounds, providing promising interventions for chronic wounds.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Genetics & Heredity
Dong Yu, Ming Bu, Ping Yu, Yaping Li, Yang Chong
Summary: Galectins are a family of proteins that have at least one carbohydrate-recognition domain and play a key role in the wound healing process. They participate in various physiological and pathological reactions such as inflammation, angiogenesis, re-epithelialisation, and fibrous scar formation. Therefore, Galectins have the potential to be used as therapeutic drugs for wounds.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Medicine, Research & Experimental
Sandra Franz, Anastasia Ertel, Kathrin M. Engel, Jan C. Simon, Anja Saalbach
Summary: This study identifies S100A9 as a previously unrecognized vital component in obesity-associated disturbed macrophage differentiation and subsequent impaired regulation of inflammation and wound repair. The findings open new opportunities for therapeutic implications for inflammatory diseases and wound repair in obesity.
Article
Engineering, Biomedical
Hao Yang, Liu Song, Bingxue Sun, Di Chu, Leilei Yang, Meng Li, Huan Li, Yun Dai, Zhuo Yu, Jianfeng Guo
Summary: The study confirmed the potential of paeoniflorin (PF) for transitioning macrophages and developed a high molecular weight hyaluronic acid (HA) hydrogel that significantly promoted cutaneous healing in experimental diabetic mice, showing promising clinical translation potential.
MATERIALS TODAY BIO
(2021)
Article
Chemistry, Multidisciplinary
Kangkang Zha, Yuan Xiong, Wenqian Zhang, Meijun Tan, Weixian Hu, Ze Lin, Peng Cheng, Li Lu, Kaiyong Cai, Bobin Mi, Qian Feng, Yanli Zhao, Guohui Liu
Summary: This study explores the ability of humic acids (HAs) to modulate the inflammatory response, particularly macrophage polarization, and the potential underlying mechanism. A near-infrared (NIR)/pH dual-responsive Cu-HAs nanoparticle (NP)-based poly(vinyl alcohol) (PVA) hydrogel film loaded with SEW2871 (SEW), a macrophage recruitment agent, was developed to treat bacteria-infected cutaneous wounds. The results show that HAs could promote M2 macrophage polarization in a dose-dependent manner. The Cu-HAs NPs successfully eradicated bacterial infection through NIR-induced local hyperthermia. This PVA@Cu-HAs NPs@SEW hydrogel film improves tissue regeneration by promoting M2 macrophage polarization, alleviating oxidative stress, enhancing angiogenesis, and facilitating collagen deposition. These findings highlight the therapeutic potential of PVA@Cu-HAs NPs@SEW hydrogel film for the treatment of bacterially infected cutaneous wound healing.
Article
Engineering, Environmental
Lu Yan, Kai Han, Bing Pang, Han Jin, Xixi Zhao, Xiaoguang Xu, Chunmei Jiang, Ning Cui, Tingli Lu, Junling Shi
Summary: The newly developed hydrogel shows great potential in treating chronic wounds of diabetic patients by regulating macrophage polarization and promoting angiogenesis.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
June Seok Heo
Summary: MSC-derived exosomes have been found to have anti-inflammatory, pro-angiogenic, and wound-repair effects in tissue engineering and regenerative medicine. Selenium-stimulated exosomes showed superior wound healing capacity, highlighting the potential of selenium as a vital agent for wound healing in stem cell-based cell-free therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Takahiro Manabe, Heamin Park, Takashi Minami
Summary: Wound healing is a complex process involving multiple cell types and signaling pathways, which can be easily impaired or dysregulated by the microenvironment, leading to the occurrence of various diseases. The calcium signaling pathway plays an important regulatory role in wound healing, affecting the progress of various healing steps.
INFLAMMATION AND REGENERATION
(2021)
Review
Biochemistry & Molecular Biology
Fa-Wei Xu, Ying-Li Lv, Yu-Fan Zhong, Ya-Nan Xue, Yong Wang, Li-Yun Zhang, Xian Hu, Wei-Qiang Tan
Summary: This review summarizes the effects of EGCG and its wound dressings on skin wound healing, including various types of EGCG-containing wound dressings and their beneficial effects at different stages of wound healing. It also explains the rationale for using EGCG to promote skin wound healing and prevent scar formation, providing a future clinical application direction.
Article
Immunology
Rogerio Marchete, Sarah Oliveira, Leonardo Bagne, Jennyffer Ione de Souza Silva, Ana Paula Valverde, Andrea Aparecida de Aro, Mariana Moreira Figueira, Marcio Fronza, Thaina Mikaela Bressam, Vivian Fernandes Furletti de Goes, Fernanda Oliveira de Gaspari de Gaspi, Glaucia Maria Tech dos Santos, Thiago Antonio Moretti Andrade
Summary: The extract of Alternanthera brasiliana exhibits important anti-inflammatory and antioxidant activities, promoting angiogenesis and tissue formation, accelerating wound healing process.
INFLAMMOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
David B. Gurevich, Phong Dang Nguyen, Ashley L. Siegel, Ophelia V. Ehrlich, Carmen Sonntag, Jennifer M. N. Phan, Silke Berger, Dhanushika Ratnayake, Lucy Hersey, Joachim Berger, Heather Verkade, Thomas E. Hall, Peter D. Currie
Article
Materials Science, Biomaterials
Claire E. Witherel, David Gurevich, John D. Collin, Paul Martin, Kara L. Spiller
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Materials Science, Biomaterials
Claire E. Witherel, David Gurevich, John D. Collin, Paul Martin, Kara L. Spiller
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Biochemistry & Molecular Biology
David B. Gurevich, Charlotte E. Severn, Catherine Twomey, Alexander Greenhough, Jenna Cash, Ashley M. Toye, Harry Mellor, Paul Martin
Article
Medicine, Research & Experimental
Alexander Greenhough, Clare Bagley, Kate J. Heesom, David B. Gurevich, David Gay, Mark Bond, Tracey J. Collard, Chris Paraskeva, Paul Martin, Owen J. Sansom, Karim Malik, Ann C. Williams
EMBO MOLECULAR MEDICINE
(2018)
Review
Biochemistry & Molecular Biology
Ashley L. Siegel, David B. Gurevich, Peter D. Currie
Article
Multidisciplinary Sciences
Phong Dang Nguyen, Georgina Elizabeth Hollway, Carmen Sonntag, Lee Barry Miles, Thomas Edward Hall, Silke Berger, Kristine Joy Fernandez, David Baruch Gurevich, Nicholas James Cole, Sara Alaei, Mirana Ramialison, Robert Lyndsay Sutherland, Jose Maria Polo, Graham John Lieschke, Peter David Currie
Article
Biochemistry & Molecular Biology
Nicholas J. Cole, Thomas E. Hall, Emily K. Don, Silke Berger, Catherine A. Boisvert, Christine Neyt, Rolf Ericsson, Jean Joss, David B. Gurevich, Peter D. Currie
Article
Cell Biology
David B. Gurevich, Kathryn E. French, John D. Collin, Stephen J. Cross, Paul Martin
JOURNAL OF CELL SCIENCE
(2020)
Article
Biology
Kazuhide S. Okuda, Mikaela Keyser, David B. Gurevich, Caterina Sturtzel, Elizabeth A. Mason, Scott Patterson, Huijun Chen, Mark Scott, Nicholas D. Condon, Paul Martin, Martin Distel, Benjamin M. Hogan
Summary: Angiogenesis is regulated by VEGF signaling pathways, with Erk playing a central role as a downstream effector. This study demonstrates the real-time imaging of Erk signaling dynamics in angiogenesis using a vascular Erk biosensor transgenic line in zebrafish. It reveals a dynamic sequence of Erk signaling events in regenerative angiogenesis, providing a new resource for studying vascular Erk signaling in real-time.
Review
Cell Biology
David B. Gurevich, Deena T. David, Ananthalakshmy Sundararaman, Jatin Patel
Summary: The vasculature is composed of heterogeneous endothelial cells that play crucial roles in the formation, maintenance, and regeneration of the vascular system, particularly during wound healing. The diversity and plasticity of endothelial cells have significant implications in disease progression, specifically in scarring and fibrosis. This review focuses on seminal discoveries defining the phenotype and mechanisms of endothelial heterogeneity, with a specific emphasis on wound healing.
Article
Cell & Tissue Engineering
Phong Dang Nguyen, David Baruch Gurevich, Carmen Sonntag, Lucy Hersey, Sara Alaei, Hieu Tri Nim, Ashley Siegel, Thomas Edward Hall, Fernando Jaime Rossello, Sarah Elizabeth Boyd, Jose Maria Polo, Peter David Currie
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)