A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters

A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry

(2021) Yunkai Zhu et al.   Nature Communications

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

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A human neutralizing antibody targets the receptor binding site of SARS-CoV-2

(2020) Rui Shi et al.   NATURE

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

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(2020) Barney S. Graham   SCIENCE

Development of an inactivated vaccine candidate for SARS-CoV-2

(2020) Qiang Gao et al.   SCIENCE

and Animal Models for SARS-CoV-2 research

(2020) Kazuo Takayama   TRENDS IN PHARMACOLOGICAL SCIENCES

A human monoclonal antibody blocking SARS-CoV-2 infection

(2020) Chunyan Wang et al.   Nature Communications

A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS

(2020) Lianpan Dai et al.   CELL

Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells

(2020) Yunlong Cao et al.   CELL

A Thermostable mRNA Vaccine against COVID-19

(2020) Na-Na Zhang et al.   CELL

Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection

(2020) Adam Brufsky et al.   Journal of Translational Medicine

Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

(2020) Noe B. Mercado et al.   NATURE

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(2020) Kizzmekia S. Corbett et al.   NATURE

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

(2020) Lihong Liu et al.   NATURE

A perspective on potential antibody-dependent enhancement of SARS-CoV-2

(2020) Ann M. Arvin et al.   NATURE

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

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Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

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Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

(2020) Ching-Lin Hsieh et al.   SCIENCE

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

(2020) Takuya Sekine et al.   CELL

Molecular Architecture of the SARS-CoV-2 Virus

(2020) Hangping Yao et al.   CELL

Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy

(2020) Shuo Du et al.   CELL

SARS-CoV-2 immunity: review and applications to phase 3 vaccine candidates

(2020) Gregory A Poland et al.   LANCET

SARS-CoV-2 vaccines in development

(2020) Florian Krammer   NATURE

Structures and distributions of SARS-CoV-2 spike proteins on intact virions

(2020) Zunlong Ke et al.   NATURE

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

(2020) Yanchun Peng et al.   NATURE IMMUNOLOGY

Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

(2020) Lisa H. Tostanoski et al.   NATURE MEDICINE

Learning from the past: development of safe and effective COVID-19 vaccines

(2020) Shan Su et al.   NATURE REVIEWS MICROBIOLOGY

Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine

(2020) Cheryl Keech et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

(2020) M. Alejandra Tortorici et al.   SCIENCE

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

(2020) Wen Shi Lee et al.   Nature Microbiology

A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

(2020) Lorena Sanchez-Felipe et al.   NATURE

Replication, pathogenicity, and transmission of SARS-CoV-2 in minks

(2020) Lei Shuai et al.   National Science Review

Virus‐Free and Live‐Cell Visualizing SARS‐CoV‐2 Cell Entry for Studies of Neutralizing Antibodies and Compound Inhibitors

(2020) Yali Zhang et al.   Small Methods

Efficacy, safety, and immunogenicity of an Escherichia coli-produced bivalent human papillomavirus vaccine: An interim analysis of a randomized clinical trial

(2019) You-Lin Qiao et al.   JNCI-Journal of the National Cancer Institute

Immunological Lessons from Respiratory Syncytial Virus Vaccine Development

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Normal Anatomy, Histology, and Spontaneous Pathology of the Kidney, and Selected Renal Biomarker Reference Ranges in the Cynomolgus Monkey

(2019) Ronnie Chamanza et al.   TOXICOLOGIC PATHOLOGY

The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery

(2018) Yun Xia et al.   CELL

Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want

(2018) Harm HogenEsch et al.   npj Vaccines

Pre-fusion structure of a human coronavirus spike protein

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Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo: Role in osteoclast-mediated NK cell activation

(2015) Han-Ching Tseng et al.   Oncotarget

Bisphosphonates for the prevention and treatment of osteoporosis

(2015) Spyridoula Maraka et al.   BMJ-British Medical Journal

Comparable quality attributes of hepatitis E vaccine antigen with and without adjuvant adsorption-dissolution treatment

(2015) Yue Zhang et al.   Human Vaccines & Immunotherapeutics

Bisphosphonates for the prevention and treatment of osteoporosis

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Virus-Specific Memory CD8 T Cells Provide Substantial Protection from Lethal Severe Acute Respiratory Syndrome Coronavirus Infection

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Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Age- and Sex-Based Hematological and Biochemical Parameters for Macaca fascicularis

(2013) Liang Xie et al.   PLoS One

T Cell Responses Are Required for Protection from Clinical Disease and for Virus Clearance in Severe Acute Respiratory Syndrome Coronavirus-Infected Mice

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Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial

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