IKKβ–NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice

LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis

(2020) Manoj Arra et al.   Nature Communications

NF-κB-mediated effects on behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis

(2020) I.M. Berke et al.   OSTEOARTHRITIS AND CARTILAGE

Age-related inflammation triggers skeletal stem/progenitor cell dysfunction

(2019) Anne Marie Josephson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chondrocyte‐Specific RUNX2 Overexpression Accelerates Post‐traumatic Osteoarthritis Progression in Adult Mice

(2019) Sarah E Catheline et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Three-dimensional microstructure of human meniscus posterior horn in health and osteoarthritis

(2019) I. Kestilä et al.   OSTEOARTHRITIS AND CARTILAGE

Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis

(2019) Kirsty L. Culley et al.   Scientific Reports

Deletion of NFKB1 enhances canonical NF-κB signaling and increases macrophage and myofibroblast content during tendon healing

(2019) Katherine T. Best et al.   Scientific Reports

NF-B Signaling Pathways in Osteoarthritic Cartilage Destruction

(2019) Choi et al.   Cells

Expression of p16INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis

(2018) Brian O. Diekman et al.   AGING CELL

Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis

(2018) Yasutaka Murahashi et al.   Scientific Reports

Aggression in group-housed laboratory mice: why can't we solve the problem?

(2017) Elin M. Weber et al.   LAB ANIMAL

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

The NF-κB1 is a key regulator of acute but not chronic renal injury

(2017) Amy Fearn et al.   Cell Death & Disease

Post-Traumatic Osteoarthritis in Mice Following Mechanical Injury to the Synovial Joint

(2017) Muhammad Farooq Rai et al.   Scientific Reports

To Group or Not to Group? Good Practice for Housing Male Laboratory Mice

(2017) Sarah Kappel et al.   Animals

Age-dependent Changes in the Articular Cartilage and Subchondral Bone of C57BL/6 Mice after Surgical Destabilization of Medial Meniscus

(2017) Henry Huang et al.   Scientific Reports

ROS/oxidative stress signaling in osteoarthritis

(2016) Panagiotis Lepetsos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

NFKB1: a suppressor of inflammation, ageing and cancer

(2016) Tyrell Cartwright et al.   FEBS Journal

Identification of Senescent Cells in the Bone Microenvironment

(2016) Joshua N Farr et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Histopathological analyses of murine menisci: implications for joint aging and osteoarthritis

(2016) J. Kwok et al.   OSTEOARTHRITIS AND CARTILAGE

Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury

(2016) Huimin Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes

(2016) Hiroshi Kobayashi et al.   Nature Communications

Loss of Nfkb1 leads to early onset aging

(2016) Giovanna M. Bernal et al.   Aging-US

Life-long caloric restriction does not alter the severity of age-related osteoarthritis

(2014) Jenna N. McNeill et al.   AGE

Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage

(2014) Wang Hui et al.   ANNALS OF THE RHEUMATIC DISEASES

The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study

(2014) Marita Cross et al.   ANNALS OF THE RHEUMATIC DISEASES

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

The IκB kinase complex in NF-κB regulation and beyond

(2013) Michael Hinz et al.   EMBO REPORTS

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

IKKα/CHUK Regulates Extracellular Matrix Remodeling Independent of Its Kinase Activity to Facilitate Articular Chondrocyte Differentiation

(2013) Eleonora Olivotto et al.   PLoS One

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

IKK-β mediates hydrogen peroxide induced cell death through p85 S6K1

(2012) C-H Jia et al.   CELL DEATH AND DIFFERENTIATION

Chronic Activation of the Kinase IKK  Impairs T Cell Function and Survival

(2012) S. Krishna et al.   JOURNAL OF IMMUNOLOGY

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

A Comprehensive Histological Assessment of Osteoarthritis Lesions in Mice

(2011) Margaret A. McNulty et al.   Cartilage

The NF-κB p50:p50:HDAC-1 repressor complex orchestrates transcriptional inhibition of multiple pro-inflammatory genes

(2010) Ahmed M. Elsharkawy et al.   JOURNAL OF HEPATOLOGY

Long bone fracture repair in mice harboring GFP reporters for cells within the osteoblastic lineage

(2010) Chikara Ushiku et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

A three-dimensional quantitative method to measure meniscus shape, position, and signal intensity using MR images: A pilot study and preliminary results in knee osteoarthritis

(2010) Wolfgang Wirth et al.   MAGNETIC RESONANCE IN MEDICINE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Cell surface-bound IL-1  is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

(2009) A. V. Orjalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High frequency of meniscal hypertrophy in persons with advanced varus knee osteoarthritis

(2009) Kwang Am Jung et al.   RHEUMATOLOGY INTERNATIONAL

Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-κBp65-specific siRNA

(2007) L.X. Chen et al.   OSTEOARTHRITIS AND CARTILAGE