Article
Geriatrics & Gerontology
Chiara Grasselli, Silvia Bombelli, Stefano Eriani, Giulia Domenici, Riccardo Galluccio, Chiara Tropeano, Sofia De Marco, Maddalena M. Bolognesi, Barbara Torsello, Cristina Bianchi, Laura Antolini, Fabio Rossi, Paolo Mazzola, Valerio Leoni, Giuseppe Bellelli, Roberto A. Perego
Summary: Frailty is an age-related syndrome that increases vulnerability and often leads to negative outcomes, including mortality. The mechanisms behind frailty are still unclear, but oxidative stress and DNA damage are believed to play a significant role. Early diagnosis and targeted treatments could potentially slow down the progression of frailty.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Edward O'Neill, Michael Mosley, Bart Cornelissen
Summary: An effective absorbed dose response relationship has not yet been established for Lutetium-177 based radionuclide therapies. The inherent biological heterogeneity of neuroendocrine and prostate cancers may make it difficult to establish cohort-based dose-response relationships. Instead, an individual-based approach that monitors the dose-response within each tumor could provide a valuable metric for monitoring treatment efficacy.
Article
Immunology
Yingze Li, Guojian Fang, Wei Cao, Jiali Yuan, Shuai Song, Hong Peng, Yuepeng Wang, Qunshan Wang
Summary: In the aged and fibrotic left atrium, replicative senescence of atrial fibroblasts (AFs) plays a significant role in the pathogenesis of atrial fibrillation. The downregulation of Ezh2, a histone methyltransferase, is identified as a key regulator of AFs' replicative senescence. This finding may have implications for future treatments of atrial fibrosis in the elderly.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Nutrition & Dietetics
Jieun Woo, Seoungwoo Shin, Hyanggi Ji, Dehun Ryu, Eunae Cho, Youngseok Kim, Junoh Kim, Deokhoon Park, Eunsun Jung
Summary: Research has shown that Isatis tinctoria L. leaf extract (ITE) can prevent and restore skin tissue aging by inhibiting cellular senescence, regulating the MAPK/NF-κB pathway, and suppressing the autophagy pathway.
Article
Food Science & Technology
Fatima Guerrero, Andres Carmona, Maria Jose Jimenez, Teresa Obrero, Victoria Pulido, Juan Antonio Moreno, Sagrario Soriano, Alejandro Martin-Malo, Pedro Aljama
Summary: The study showed that uremic toxins cause accelerated aging in HUVECs, affecting their regenerative capacity and potential to form vascular structures. This phenomenon may contribute to endothelial dysfunction associated with CKD progression.
Editorial Material
Biology
Na Yang, Payel Sen
Summary: Many senescence-associated features gradually emerge before cells cease to divide.
Article
Geriatrics & Gerontology
Yasunori Fujita, Masumi Iketani, Masafumi Ito, Ikuroh Ohsawa
Summary: Mitochondrial dysfunction and excessive generation of mitochondrial ROS do not predominantly occur in the transition phase and may not play a role in the development of replicative senescence in normal diploid TIG-1 fibroblasts.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Geriatrics & Gerontology
Laura Gennaccaro, Claudia Fuchs, Manuela Loi, Riccardo Pizzo, Sara Alvente, Chiara Berteotti, Leonardo Lupori, Giulia Sagona, Giuseppe Galvani, Antonia Gurgone, Alessandra Raspanti, Giorgio Medici, Marianna Tassinari, Stefania Trazzi, Elisa Ren, Roberto Rimondini, Tommaso Pizzorusso, Giovanna Zoccoli, Maurizio Giustetto, Elisabetta Ciani
Summary: CDD is a severe neurodevelopmental disease caused by mutations in the X-linked CDKL5 gene, characterized by early-onset epilepsy, intellectual disability, motor impairment, and autistic-like features. The decline in behaviors in older Cdk15 KO mice was associated with decreased neuronal survival, but not worsened neuroanatomical alterations. Evidence was found that CDKL5 may play a fundamental role in neuronal survival during brain aging, suggesting a possible worsening with age of the clinical picture in CDD patients.
Article
Cardiac & Cardiovascular Systems
Diem Duong Ngoc Nguyen, Shamsul Mohd Zain, Mohd Hamzah Kamarulzaman, Teck Yew Low, William M. Chilian, Yan Pan, Kang Nee Ting, Aini Hamid, Arifah Abdul Kadir, Yuh-Fen Pung
Summary: The study focused on the intracellular and exosomal miRNA profiling in human vascular smooth muscle cells during replicative senescence. Specific dysregulated sets of miRNAs were identified from human vascular smooth muscle cells. Hsa-miR-155-5p was significantly downregulated in both intracellular and exosomal hVSMCs, suggesting its crucial role in cellular senescence. Hsa-miR-155-5p might be the mediator in linking cellular senescence to vascular aging and atherosclerosis.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Letter
Biochemical Research Methods
Dmitry S. Sitnikov, Veronika A. Revkova, Inna V. Ilina, Svetlana A. Gurova, Pavel S. Komarov, Evgenia V. Struleva, Mikhail A. Konoplyannikov, Vladimir A. Kalsin, Vladimir P. Baklaushev
Summary: This study evaluated the genotoxic effects of terahertz (THz) radiation on cell cultures, and found that genotoxicity only occurred when the peak intensity and electric field strength exceeded a certain threshold. Furthermore, in tumor cell lines, exposure to high-intensity THz radiation did not result in significant genotoxic effects.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Geriatrics & Gerontology
Hongjie Wang, Mohan Kumar Muthu Karuppan, Dinesh Devadoss, Madhavan Nair, Hitendra S. Chand, Madepalli Krishnappa Lakshmana
Summary: TFEB protein levels decrease in aging mice, but ectopic expression of TFEB in transgenic mice leads to increased mitochondria numbers, reduced markers of senescence, improved memory skills, suggesting that TFEB may help delay neuronal aging and enhance cognitive abilities.
NEUROBIOLOGY OF AGING
(2021)
Article
Biochemistry & Molecular Biology
Ioannis I. Moustakas, Angeliki Katsarou, Aigli-Ioanna Legaki, Iryna Pyrina, Konstantinos Ntostoglou, Alkistis-Maria Papatheodoridi, Bettina Gercken, Ioannis S. Pateras, Vassilis G. Gorgoulis, Michael Koutsilieris, Triantafyllos Chavakis, Antonios Chatzigeorgiou
Summary: Senescence is involved in the development of nonalcoholic fatty liver disease (NAFLD) independently of age, with stress-induced senescence playing a role in steatosis development. Hepatocyte senescence was observed in young mice subjected to different diet-induced NAFLD models, with increased expression of senescence-associated genes and presence of senescence-specific staining in the liver. Telomere length and global DNA methylation did not differ between steatotic and control livers, while oxidative stress marker malondialdehyde was upregulated in NAFLD mouse livers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Zheng-Mei Xiong, Xiaojing Mao, Mason Trappio, Chanda Arya, Jasmin El Kordi, Kan Cao
Summary: Methylene blue, as a premier antioxidant, has shown potential as a sunscreen active ingredient for UV radiation protection. In comparison to oxybenzone, it exhibits better UVB absorption efficiency, prevents UVB-induced DNA damage, and does not harm coral reefs, suggesting its promise as a coral reef-friendly sunscreen active ingredient.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Cell Biology
Jake Atkinson, Eva Bezak, Ivan Kempson
Summary: DNA double-strand breaks play a fundamental role in cell biology, but there is a lack of a reliable assay for quantitatively visualizing DSBs. Relying on proxy detection methods can lead to misinterpretation of conventional assays, highlighting the need for the development of more accurate DSB detection methods.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Cell Biology
Cristina Almenglo, Pilar Caamano, Maximo Fraga, Jesus Devesa, Jose A. Costoya, Victor M. Arce
Summary: GBM, the most common and aggressive primary brain tumor in adults, presents vast genetic variation and phenotypic diversity, making therapeutic strategy development challenging. Transformation of primary mouse embryo astrocytes into immortalized cultures with neural stem cell characteristics provides a model for studying gliomagenesis and testing drug effectiveness throughout GBM's natural history.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)