A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions
出版年份 2021 全文链接
标题
A DNA repair pathway can regulate transcriptional noise to promote cell fate transitions
作者
关键词
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出版物
SCIENCE
Volume 373, Issue 6557, Pages eabc6506
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2021-07-23
DOI
10.1126/science.abc6506
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Transcription in Living Cells: Molecular Mechanisms of Bursting
- (2020) Joseph Rodriguez et al. Annual Review of Biochemistry
- Noise-driven cellular heterogeneity in circadian periodicity
- (2020) Yan Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Long-Distance Cooperative and Antagonistic RNA Polymerase Dynamics via DNA Supercoiling
- (2019) Sangjin Kim et al. CELL
- Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming
- (2019) Kimberley N. Babos et al. Cell Stem Cell
- Mechanism of stimulation of DNA binding of the transcription factors by human apurinic/apyrimidinic endonuclease 1, APE1
- (2019) Milena Bazlekowa-Karaban et al. DNA REPAIR
- A Post-Transcriptional Feedback Mechanism for Noise Suppression and Fate Stabilization
- (2018) Maike M.K. Hansen et al. CELL
- The role of the N-terminal domain of human apurinic/apyrimidinic endonuclease 1, APE1, in DNA glycosylase stimulation
- (2018) Olga A. Kladova et al. DNA REPAIR
- Integrating single-cell transcriptomic data across different conditions, technologies, and species
- (2018) Andrew Butler et al. NATURE BIOTECHNOLOGY
- Modulation of transcriptional burst frequency by histone acetylation
- (2018) Damien Nicolas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia
- (2018) Luis A. Carvajal et al. Science Translational Medicine
- CellProfiler 3.0: Next-generation image processing for biology
- (2018) Claire McQuin et al. PLOS BIOLOGY
- Cytoplasmic Amplification of Transcriptional Noise Generates Substantial Cell-to-Cell Variability
- (2018) Maike M.K. Hansen et al. Cell Systems
- Correcting the Mean-Variance Dependency for Differential Variability Testing Using Single-Cell RNA Sequencing Data
- (2018) Nils Eling et al. Cell Systems
- Transcription-induced supercoiling as the driving force of chromatin loop extrusion during formation of TADs in interphase chromosomes
- (2017) Dusan Racko et al. NUCLEIC ACIDS RESEARCH
- Measurement of incorporation kinetics of non-fluorescent native nucleotides by DNA polymerases using fluorescence microscopy
- (2017) Matthew T. Walsh et al. NUCLEIC ACIDS RESEARCH
- Cell population structure prior to bifurcation predicts efficiency of directed differentiation in human induced pluripotent cells
- (2017) Rhishikesh Bargaje et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells
- (2017) Stefan Semrau et al. Nature Communications
- Discrete distributional differential expression (D3E) - a tool for gene expression analysis of single-cell RNA-seq data
- (2016) Mihails Delmans et al. BMC BIOINFORMATICS
- Mechanical bounds to transcriptional noise
- (2016) Stuart A. Sevier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting
- (2016) Katjana Tantale et al. Nature Communications
- Cell Fate Decision as High-Dimensional Critical State Transition
- (2016) Mitra Mojtahedi et al. PLOS BIOLOGY
- Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
- (2016) Max A Horlbeck et al. eLife
- Transcriptional Bursting Explains the Noise–Versus–Mean Relationship in mRNA and Protein Levels
- (2016) Roy D. Dar et al. PLoS One
- destiny: diffusion maps for large-scale single-cell data in R
- (2015) Philipp Angerer et al. BIOINFORMATICS
- A Hardwired HIV Latency Program
- (2015) Brandon S. Razooky et al. CELL
- Computational assignment of cell-cycle stage from single-cell transcriptome data
- (2015) Antonio Scialdone et al. METHODS
- Structure of silent transcription intervals and noise characteristics of mammalian genes
- (2015) B. Zoller et al. Molecular Systems Biology
- Nuclear Retention of mRNA in Mammalian Tissues
- (2015) Keren Bahar Halpern et al. Cell Reports
- Neural Differentiation of Mouse Embryonic Stem Cells in Serum-free Monolayer Culture
- (2015) Wikrom Wongpaiboonwattana et al. Jove-Journal of Visualized Experiments
- Transcription Factor Competition Allows Embryonic Stem Cells to Distinguish Authentic Signals from Noise
- (2015) Cameron Sokolik et al. Cell Systems
- Transient Changes in Intercellular Protein Variability Identify Sources of Noise in Gene Expression
- (2014) Abhyudai Singh BIOPHYSICAL JOURNAL
- Mechanism of Transcriptional Bursting in Bacteria
- (2014) Shasha Chong et al. CELL
- Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency
- (2014) Elsa Abranches et al. DEVELOPMENT
- Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA
- (2014) Toni Pfaffeneder et al. Nature Chemical Biology
- TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation
- (2014) Udo Müller et al. NUCLEIC ACIDS RESEARCH
- Screening for noise in gene expression identifies drug synergies
- (2014) R. D. Dar et al. SCIENCE
- Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells
- (2014) Hiroshi Ochiai et al. Scientific Reports
- Genome-wide Analysis Reveals TET- and TDG-Dependent 5-Methylcytosine Oxidation Dynamics
- (2013) Li Shen et al. CELL
- FISH-quant: automatic counting of transcripts in 3D FISH images
- (2013) Florian Mueller et al. NATURE METHODS
- Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures
- (2013) Catherine Naughton et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Transcription-generated torsional stress destabilizes nucleosomes
- (2013) Sheila S Teves et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Transcriptional burst frequency and burst size are equally modulated across the human genome
- (2012) R. D. Dar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Using Gene Expression Noise to Understand Gene Regulation
- (2012) B. Munsky et al. SCIENCE
- Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells
- (2011) Piyush B. Gupta et al. CELL
- Mammalian Genes Are Transcribed with Widely Different Bursting Kinetics
- (2011) D. M. Suter et al. SCIENCE
- Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
- (2011) Y.-F. He et al. SCIENCE
- Pausing of RNA Polymerase II Disrupts DNA-Specified Nucleosome Organization to Enable Precise Gene Regulation
- (2010) Daniel A. Gilchrist et al. CELL
- Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
- (2010) Shinsuke Ito et al. NATURE
- Thymidine analog methods for studies of adult neurogenesis are not equally sensitive
- (2009) Benedetta Leuner et al. JOURNAL OF COMPARATIVE NEUROLOGY
- CD15, CD24 and CD29 Define a Surface Biomarker Code for Neural Lineage Differentiation of Stem Cells
- (2009) Jan Pruszak et al. STEM CELLS
- Regulated Fluctuations in Nanog Expression Mediate Cell Fate Decisions in Embryonic Stem Cells
- (2009) Tibor Kalmar et al. PLOS BIOLOGY
- Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences
- (2008) Arjun Raj et al. CELL
- Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells
- (2008) Muralidhar L Hegde et al. CELL RESEARCH
- Database for mRNA Half-Life of 19 977 Genes Obtained by DNA Microarray Analysis of Pluripotent and Differentiating Mouse Embryonic Stem Cells
- (2008) L. V. Sharova et al. DNA RESEARCH
- Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
- (2008) Hannah H. Chang et al. NATURE
- The functional response of upstream DNA to dynamic supercoiling in vivo
- (2008) Fedor Kouzine et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Nuclear protein-induced bending and flexing of the hypoxic response element of the rat vascular endothelial growth factor promoter
- (2007) Jeffrey F. Breit et al. FASEB JOURNAL
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