期刊
PHARMACOLOGICAL RESEARCH
卷 169, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2021.105608
关键词
Liver organoid; Drug validation; Toxicity assessment
资金
- National Health and Medical Research Council of Australia [APP1125794, APP1055176]
- Gallipoli Medical Research Foundation
Liver organoids, as self-organising and self-renewing models, provide a more physiologically relevant approach for disease modelling and personalized therapy. They are essential tools for testing drug efficacy and toxicity, facilitating drug validation and toxicity assessment.
The past decade has seen many advancements in the development of three-dimensional (3D) in vitro models in pharmaceutical sciences and industry. Specifically, organoids present a self-organising, self-renewing and more physiologically relevant model than conventional two-dimensional (2D) cell cultures. Liver organoids have been developed from a variety of cell sources, including stem cells, cell lines and primary cells. They have potential for modelling patient-specific disease and establishing personalised therapeutic approaches. Additionally, liver organoids have been used to test drug efficacy and toxicity. Herein we summarise cell sources for generating liver organoids, the advantages and limitations of each cell type, as well as the application of the organoids in modelling liver diseases. We focus on the use of liver organoids as tools for drug validation and toxicity assessment.
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