Large-Scale Cyclopropanation of Butyl Acrylate with Difluorocarbene and Classical Resolution of a Key Fluorinated Building Block

The preparation and properties of 1,1-difluorocyclopropane derivatives

(2021) Kymbat S Adekenova et al.   Beilstein Journal of Organic Chemistry

Where does the Fluorine come from? A review on the challenges associated with the synthesis of organofluorine compounds.

(2020) Stephane Caron   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous Process for Preparing the Difluoromethylating Reagent [(DMPU)2Zn(CF2H)2] and Improved Synthesis of the ICHF2 Precursor

(2020) Sebastien Monfette et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Difluorocarbene Generation from TMSCF3: Kinetics and Mechanism of NaI-Mediated and Si-Induced Anionic Chain Reactions

(2020) Andrés García-Domínguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Indolizines from Pyridinium Salts and Ethyl Bromodifluoroacetate

(2020) Xiaoya Hou et al.   ORGANIC LETTERS

Difluorocarbene as a Building Block for Consecutive Bond-Forming Reactions

(2018) Alexander D. Dilman et al.   ACCOUNTS OF CHEMICAL RESEARCH

Dual role of ethyl bromodifluoroacetate in the formation of fluorine-containing heteroaromatic compounds

(2018) Xingxing Ma et al.   CHEMICAL COMMUNICATIONS

Synthesis of Functionalized Difluorocyclopropanes: Unique Building Blocks for Drug Discovery

(2018) Roman M. Bychek et al.   CHEMISTRY-A EUROPEAN JOURNAL

Transition Metal-free gem -difluorocyclopropanation of Alkenes with CF3 SiMe3 −NaI System: a Recipe for Electron-deficient Substrates

(2018) Pavel S. Nosik et al.   ADVANCED SYNTHESIS & CATALYSIS

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

(2018) Andrew Fensome et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rapid Synthesis of γ-Arylated Carbonyls Enabled by the Merge of Copper- and Photocatalytic Radical Relay Alkylarylation of Alkenes

(2018) Xu-Lu Lv et al.   ORGANIC LETTERS

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules

(2016) Tanaji T. Talele   JOURNAL OF MEDICINAL CHEMISTRY

Silicon Reagent with Functionalized Tetrafluoroethylene Fragments: Preparation and Coupling with Aldehydes

(2016) Oleg V. Fedorov et al.   JOURNAL OF ORGANIC CHEMISTRY

Difluorocarbene Addition to Alkenes and Alkynes in Continuous Flow

(2016) Pauline Rullière et al.   ORGANIC LETTERS

Trifluoromethyltrimethylsilane: Nucleophilic Trifluoromethylation and Beyond

(2014) Xiao Liu et al.   CHEMICAL REVIEWS

Visible-Light-Mediated Fluoroalkylation of Isocyanides with Ethyl Bromofluoroacetates: Unified Synthesis of Mono- and Difluoromethylated Phenanthridine Derivatives

(2014) Xiaoyang Sun et al.   ORGANIC LETTERS

Recent Advances in the Synthetic Application of Difluorocarbene

(2014) Jinbo Hu et al.   SYNTHESIS-STUTTGART

Synthesis ofgem-Difluorocyclopropa(e)nes and O-, S-, N-, and P-Difluoromethylated Compounds with TMSCF2Br

(2013) Lingchun Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Methyl 2,2-Difluoro-2-(fluorosulfonyl)acetate, a Difluorocarbene Reagent with Reactivity Comparable to That of Trimethylsilyl 2,2-Difluoro-2-(fluorosulfonyl)acetate (TFDA)

(2012) Steffen Eusterwiemann et al.   JOURNAL OF ORGANIC CHEMISTRY

A Safe and Practical Procedure for the Difluoromethylation of Methyl 4-Hydroxy-3-iodobenzoate

(2011) Jeffrey B. Sperry et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Sodium Bromodifluoroacetate: A Difluorocarbene Source for the Synthesis of gem-Difluorocyclopropanes

(2010) Hideki Amii et al.   SYNTHESIS-STUTTGART