标题
The preparation and properties of 1,1-difluorocyclopropane derivatives
作者
关键词
-
出版物
Beilstein Journal of Organic Chemistry
Volume 17, Issue -, Pages 245-272
出版商
Beilstein Institut
发表日期
2021-01-26
DOI
10.3762/bjoc.17.25
参考文献
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- (2020) K. C. Nicolaou et al. JOURNAL OF ORGANIC CHEMISTRY
- Access to Divergent Fluorinated Enynes and Arenes via Palladium-Catalyzed Ring-Opening Alkynylation of gem-Difluorinated Cyclopropanes
- (2020) Ebrahim-Alkhalil M. A. Ahmed et al. ORGANIC LETTERS
- Synthesis of organic liquid crystals containing selectively fluorinated cyclopropanes
- (2020) Zeguo Fang et al. Beilstein Journal of Organic Chemistry
- gem -Difluorocyclopropanation of Alkenyl Trifluoroborates with the CF3 SiMe3 -NaI System
- (2020) Oleksandr V. Hryshchuk et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- TYK2/JAK1 Inhibitor PF-06700841 in Patients with Plaque Psoriasis: Phase IIa, Randomized, Double-blind, Placebo-controlled Trial
- (2020) Seth B. Forman et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Enantioselective Functionalization of Difluorocyclopropenes Catalyzed by Chiral Copper Complexes: Proposal for Chiral gem-Dimethyl and tert-Butyl Analogues
- (2020) Keisuke Sekine et al. JOURNAL OF ORGANIC CHEMISTRY
- Potential Explosion Hazards Associated with the Autocatalytic Thermal Decomposition of Dimethyl Sulfoxide and Its Mixtures
- (2020) Qiang Yang et al. ORGANIC PROCESS RESEARCH & DEVELOPMENT
- Asymmetric transfer hydrogenation of gem‐difluoro‐cyclopropenyl esters. Access to enantio‐enriched gem‐difluorocyclopropanes
- (2020) Christophe Meyer et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Gold Difluorocarbenoid Complexes: Spectroscopic and Chemical Profiling
- (2019) Alexander G. Tskhovrebov et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Synthesis of gem-Difluoromethylene Containing Cycloalkenes via the Ring-Opening Reaction of gem-Difluorocyclopropanes and Subsequent RCM Reaction
- (2019) Yoshihiro Masuhara et al. JOURNAL OF ORGANIC CHEMISTRY
- Ring-Opening Functionalization of Simple gem-Difluorocyclopropanes by Single-Electron Oxidants
- (2019) Toshihito Goto et al. JOURNAL OF ORGANIC CHEMISTRY
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- (2019) Jiabin Ni et al. JOURNAL OF ORGANIC CHEMISTRY
- Fluorinated cyclopropanes: synthesis and chemistry of the aryl α,β,β-trifluorocyclopropane motif
- (2018) Connor J. Thomson et al. CHEMICAL COMMUNICATIONS
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- (2018) Roman M. Bychek et al. CHEMISTRY-A EUROPEAN JOURNAL
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- (2018) Hiroaki Takenaka et al. ORGANIC & BIOMOLECULAR CHEMISTRY
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- (2017) Krzysztof Grudzień et al. JOURNAL OF FLUORINE CHEMISTRY
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- (2014) Hideki Amii et al. SYNLETT
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- (2014) Joseph Sweeney et al. SYNLETT
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- (2013) Lingchun Li et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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- (2013) Yuzo Nakamura et al. Beilstein Journal of Organic Chemistry
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- (2013) Jian Zheng et al. CHEMICAL COMMUNICATIONS
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- (2013) Tang-Po Yang et al. CHEMICAL COMMUNICATIONS
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- (2013) Tang-Po Yang et al. CHEMICAL COMMUNICATIONS
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- (2013) Jian Zheng et al. CHEMISTRY-A EUROPEAN JOURNAL
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- (2012) Steffen Eusterwiemann et al. JOURNAL OF ORGANIC CHEMISTRY
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- (2011) Fei Wang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Correction to Ring-Opening Reactions of Difluoro(methylene)cyclopropanes with Halogens and Amines
- (2011) Xiao-Chun Hang et al. JOURNAL OF ORGANIC CHEMISTRY
- Friedel−Crafts Reactions of 2,2-Difluorocyclopropanecarbonyl Chloride: Unexpected Ring-Opening Chemistry
- (2011) William R. Dolbier et al. JOURNAL OF ORGANIC CHEMISTRY
- Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes
- (2010) Fei Wang et al. CHEMICAL COMMUNICATIONS
- Magnesium iodide promoted defluorinative reactions of 2,2-difluorocyclopropyl aryl ketones with aryl imines: A new, general synthesis of 2-alkylideneazetidines
- (2010) Wei Xu et al. JOURNAL OF FLUORINE CHEMISTRY
- Thermal rearrangement of substituted difluoro(methylene)cyclopropane
- (2010) Xiao-Chun Hang et al. JOURNAL OF FLUORINE CHEMISTRY
- Sodium Bromodifluoroacetate: A Difluorocarbene Source for the Synthesis of gem-Difluorocyclopropanes
- (2010) Hideki Amii et al. SYNTHESIS-STUTTGART
- A New Synthesis of Difluorodiazirine and the Absolute Reactivity of Difluorocarbene
- (2009) Robert A. Moss et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Reaction of difluorocarbene with propargyl esters and efficient synthesis of difluorocyclopropyl ketones
- (2009) Xiao-Chun Hang et al. TETRAHEDRON
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- (2008) Wei Xu et al. JOURNAL OF ORGANIC CHEMISTRY
- Ring-Opening Reactions of Difluoro(methylene)cyclopropanes with Halogens and Amines
- (2008) Xiao-Chun Hang et al. JOURNAL OF ORGANIC CHEMISTRY
- Boron-Substituted Difluorocyclopropanes: New Building Blocks ofgem-Difluorocyclopropanes
- (2008) Yasutaka Fujioka et al. ORGANIC LETTERS
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