Review
Gastroenterology & Hepatology
Carlo Romano Settanni, Stefano Bibbo, Gianluca Ianiro, Emanuele Rinninella, Marco Cintoni, Maria Cristina Mele, Giovanni Cammarota, Antonio Gasbarrini
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, social interaction, and repetitive behaviors. Patients with ASD often experience gastrointestinal (GI) symptoms, which are modulated by the gut microbiota through the 'microbiota-gut-brain axis'. Strategies to alleviate GI distress in ASD patients include antimicrobials, probiotics, prebiotics, fecal microbiota transplantation, and dietary intervention.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Lei Xu, Chung S. Yang, Yanan Liu, Xin Zhang
Summary: This article reviews the possible approach of modulating microbiota to prevent and treat respiratory tract infections, including COVID-19. The gut microbiota can affect lung immune function through the gut-lung axis, and beneficial bacteria can enhance human immunity and reduce the incidence and severity of infection. The use of probiotics and prebiotics can modulate the gut microbiota to prevent or alleviate COVID-19.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Mihaela Cristina Buhas, Laura Ioana Gavrilas, Rares Candrea, Adrian Catinean, Andrei Mocan, Doina Miere, Alexandru Tataru
Summary: Psoriasis is a chronic inflammatory skin disease with autoimmune characteristics, and its pathogenesis is closely related to gut microbiota. Modulation of gut microbiota through dietary approaches or supplementation with probiotics and prebiotics could serve as a novel therapeutic approach for psoriasis.
Review
Biochemistry & Molecular Biology
Agata Chudzik, Anna Orzylowska, Radoslaw Rola, Greg J. Stanisz
Summary: The brain-gut-microbiome axis is a bidirectional communication pathway between the gut microbiota and the central nervous system. Studies have shown that certain probiotics can help alleviate symptoms of depression, and clinical trials have demonstrated improvements in mood and changes in biochemical parameters in patients with depressive disorders.
Review
Veterinary Sciences
Andrew R. Williams, Laura J. Myhill, Sophie Stolzenbach, Peter Nejsum, Helena Mejer, Dennis S. Nielsen, Stig M. Thamsborg
Summary: Nutritional manipulation of the commensal gut microbiota may play a key role in maintaining animal health and production, particularly in an era of reduced antimicrobial usage. Host diet can influence the interaction between helminth infection and GM, which may inform future helminth control strategies and the application of health-promoting feed additives.
BMC VETERINARY RESEARCH
(2021)
Review
Food Science & Technology
Yuan-Wei Zhang, Mu-Min Cao, Ying-Juan Li, Guang-Chun Dai, Pan-Pan Lu, Ming Zhang, Li-Yong Bai, Xiang-Xu Chen, Cheng Zhang, Liu Shi, Yun-Feng Rui
Summary: This review explores the potential mechanisms of probiotics and prebiotics on osteoporosis, focusing on the regulation of intestinal metabolites, intestinal epithelial barrier function, involvement of neuromodulation, immune regulation, and endocrine regulation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Immunology
Shuting Tong, Peiyu Zhang, Qi Cheng, Mo Chen, Xin Chen, Zitao Wang, Xiaoyong Lu, Huaxiang Wu
Summary: This article summarizes the role of gut microbiota in the onset and progression of gout, discusses its importance in the diagnosis and treatment of gout, and explores potential therapeutic approaches targeting the gut microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Microbiology
Pengya Feng, Shuai Zhao, Yangyang Zhang, Enyao Li
Summary: Autism spectrum disorders (ASD) have a significant impact on society. This review analyzes preclinical and clinical research to provide evidence for the association between ASD and gut-brain axis dysregulation, and suggests that probiotics may be a potential treatment for ASD.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Psychiatry
Chiara Puricelli, Roberta Rolla, Luca Gigliotti, Elena Boggio, Eleonora Beltrami, Umberto Dianzani, Roberto Keller
Summary: The large microbial population in the human gut has drawn significant interest in recent decades. It is now known to play a crucial role in health and disease, affecting not only intestinal homeostasis but also seemingly unrelated body systems such as the immune and nervous systems. A novel theory proposes a link between the gut microbial flora and the pathogenesis of neurological and neurodevelopmental disorders, including autism spectrum disorders. This groundbreaking theory has also opened up possibilities for modifying the gut microbiota to treat and prevent various pathologies.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Psychology, Multidisciplinary
Chang Lu, Jiaqi Rong, Changxing Fu, Wenshi Wang, Jing Xu, Xing-Da Ju
Summary: Autism Spectrum Disorder (ASD) patients have different intestinal microbiota composition from typical children, and rebalancing the microbiota may help improve ASD symptoms. Lactobacillus plantarum may be an effective probiotic, but rebalancing the microbiota through microbiota transfer therapy (MMT) could be more crucial.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Davide Banfi, Elisabetta Moro, Annalisa Bosi, Michela Bistoletti, Silvia Cerantola, Francesca Crema, Fabrizio Maggi, Maria Cecilia Giron, Cristina Giaroni, Andreina Baj
Summary: This article discusses the role of the microbiota-gut-brain axis in the pathogenesis of Inflammatory Bowel Disease (IBD) and the impact of microbial-derived metabolites on the development of IBD-related symptoms. It points out that mood disorders and heightened stress responses may affect the severity of IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Yinxi He, Yanxia Chen
Summary: This article summarizes the relationship between gut microbiota and osteoporosis, and discusses the positive therapeutic effects of probiotics, prebiotics, and traditional Chinese medicine on improving bone metabolism. The research suggests that gut microbiota may be a new therapeutic target for treating osteoporosis and preventing fractures.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Biology
Kotryna Simonyte Sjodin, Andreas Sjodin, Marek Ruszczynski, Mette Bach Kristensen, Olle Hernell, Hania Szajewska, Christina E. E. West
Summary: Adding synbiotics to formula milk can prevent infections in infants. This study found that synbiotic feeding led to the development of a healthier gut microbiota, with lower levels of Klebsiella and higher levels of Bifidobacterium. It also increased the production of metabolites associated with immune signaling.
Review
Nutrition & Dietetics
Tarkan Karakan, Ceren Ozkul, Esra Kupeli Akkol, Saniye Bilici, Eduardo Sobarzo-Sanchez, Raffaele Capasso
Summary: The composition and function of gut microbiota play a crucial role in functional gastrointestinal disorders, with a bidirectional communication between the gut and the central nervous system. Antibiotic-induced dysbiosis is identified as a significant factor for the occurrence of these disorders, affecting the gut-brain axis and potentially leading to cognitive and mood disorders. Both animal and human trials provide strong evidence for the causal relationship between gut microbiota and brain functions, highlighting new therapeutic implications for pathogenic pathways.
Review
Food Science & Technology
Chen Wang, Junying Bai, Xiaoyong Chen, Jiajia Song, Yu Zhang, Hongwei Wang, Huayi Suo
Summary: Host health and disease are affected by changes in intestinal flora. Strategies such as probiotics, prebiotics, diet, fecal microbiota transplantation, antibiotics, and phages can regulate the structure and abundance of microflora. Diets and prebiotics have reduced risk and high security, while phages have high specificity for targeted regulation. Individual variability in microflora and metabolic response should be considered, and future studies should use artificial intelligence and multi-omics to develop personalized intervention strategies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Medicine, General & Internal
Sule Yilmaz, Memduha Tas, Erdogan Bulut
Summary: Children with phonological disorder did not show significant differences in contralateral suppression of transient evoked otoacoustic emissions compared to typically developing controls. There were no asymmetries in transient evoked otoacoustic emissions suppression between the two groups.
BALKAN MEDICAL JOURNAL
(2021)
Review
Medicine, General & Internal
Rebecca S. Eshraghi, Camron Davies, Rahul Iyengar, Linda Perez, Rahul Mittal, Adrien A. Eshraghi
Summary: The gut microbiome has been recognized as a major contributor to the pathogenesis of inflammatory disorders, modulating complex signaling pathways through the gut-brain-axis and influencing neurodevelopment. Dysregulation of the GBA may play a causal role in the pathophysiology of autism spectrum disorder by compromising BBB integrity and immunological function. Understanding the interactions between gut microbes, metabolites, neural development, immune mediators, and neurobiological functionality will aid in developing targeted therapeutic approaches for ASD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Otorhinolaryngology
Sinan Eroglu, Rasit Cevizci, Handan Turan Dizdar, Hasan Deniz Tansuker, Erdogan Bulut, Alper Dilci, Selin Ustun, Serap Sirvanci, Ozlem Tugce Kaya, Dilara Bayazit, Burak Omur Cakir, Mehmet Faruk Oktay, Yildirim Ahmet Bayazit
Summary: This study evaluated the association of CHL with structural changes in the organ of Corti, finding that inner ear damage may be linked to CHL, with severity potentially correlated to the duration and severity of CHL. Early correction of CHL is recommended to prevent or reverse inner ear damage progression and improve success rates of hearing restoration surgeries. Subjective differences and compliance among hearing aid users may be influenced by the impact of CHL on inner ear structures.
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY
(2021)
Article
Audiology & Speech-Language Pathology
Selis Gulseven Guven, Onur Ersoy, Ruhan Deniz Topuz, Erdogan Bulut, Gulnur Kizilay, Cem Uzun
Summary: The study found that orally administered MSG in guinea pigs at commonly utilized quantity and route of administration in humans may have cochleotoxic effects, leading to degeneration and cell loss in outer hair cells, support cells, and spiral ganglia.
AUDIOLOGY AND NEURO-OTOLOGY
(2022)
Review
Audiology & Speech-Language Pathology
Jenna E. Bergman, Camron Davies, Alexa J. Denton, Peter E. Ashman, Rahul Mittal, Adrien A. Eshraghi
Summary: The use of organoids in stem cell therapy shows promise in creating functional replacement cells for irreversible hearing loss, potentially providing crucial information for restoring sensorineural hearing loss. Further advancements are needed to address challenges associated with stem cell-based regenerative therapy.
JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY
(2021)
Review
Medicine, General & Internal
Camron Davies, Jenna Bergman, Carly Misztal, Renuka Ramchandran, Jeenu Mittal, Erdogan Bulut, Viraj Shah, Rahul Mittal, Adrien A. Eshraghi
Summary: Most USH patients benefit from CI, with younger patients generally achieving better outcomes in hearing, speech, and cognition. Prolonged auditory deprivation may lead to poorer performance outcomes post-CI. Further research is needed to understand gene mutations underlying USH pathophysiology for optimal timing of CI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Ezgi Bulut, Ebru Tastekin, Canberk Topuz, Sevgi Ozturk, Ali Gokyer
Summary: Skin metastases from gastric adenocarcinoma are rare and have a poor prognosis. It may be the initial manifestation of an undetected visceral cancer or a recurrence of an internal malignancy. Early detection and appropriate treatment are crucial for improving patient outcomes.
JOURNAL OF GASTROINTESTINAL CANCER
(2022)
Article
Medicine, Research & Experimental
Camron Davies, Daniel Gorelik, Andrew P. Lane, Masayoshi Takashima, Omar G. Ahmed
Article
Medicine, General & Internal
Camron Davies, Rahul Mittal, Crystal Y. Li, Hannah Marwede, Jenna Bergman, Nia Hilton, Jeenu Mittal, Sanjoy K. Bhattacharya, Adrien A. Eshraghi
Summary: Given the non-labile, terminal differentiation of inner-ear sensory cells, preserving their function is critical since sensory cell damage results in irreversible hearing loss. Gentamicin-induced cytotoxicity is one of the major causes of sensory cell damage and consequent sensorineural hearing loss. This study aimed to identify target proteins involved in gentamicin-induced cytotoxicity to better understand the molecular pathways of sensory cell damage.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Sunny Shah, Rameen Walters, Jake Langlie, Camron Davies, Ariel Finberg, Maria-Pia Tuset, Dario Ebode, Rahul Mittal, Adrien A. Eshraghi
Summary: This study evaluates the outcomes of cochlear implantation in patients with severe to profound sensorineural hearing loss due to inner ear malformations (IEMs) compared to patients without IEMs. The study found that patients with IEMs have a higher risk of intraoperative complications and may have less favorable audiological outcomes compared to patients without IEMs. Precautionary measures such as preoperative imaging and proper counseling are recommended in this population.
Article
Clinical Neurology
Ahmet Mutlu, Ayse Yasemin Gunduz, Burcu Bakici Balci, Murat Erinc, Erdogan Bulut, Onur Ersoy, Mahmut Tayyar Kalcioglu
Summary: This study aimed to investigate the ototoxic effects of HOCl on an animal model, and found that although HOCl is less ototoxic than the disinfectant used, it may still have a toxic effect on cochlea. Interestingly, a partial recovery in hearing levels was observed in the HOCl group within the study period.
OTOLOGY & NEUROTOLOGY
(2022)
Review
Medicine, General & Internal
Camron Davies, Moeed Moosa, Keelin McKenna, Jeenu Mittal, Idil Memis, Rahul Mittal, Adrien A. A. Eshraghi
Summary: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with a high prevalence and economic impact. Limited knowledge exists regarding neurosensory disorders and co-occurring medical conditions in the ASD population, especially in autistic women. This systematic review aims to explore the quality of life and prevalence of neurosensory disorders and co-occurring medical conditions in individuals with ASD, with a special focus on autistic females. The review highlights concerns such as psychiatric conditions, GI-related disturbances, and chronic pain in autistic females compared to their male counterparts.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Chad A. Nieri, Camron M. Davies, Jordan B. Luttrell, Anthony Sheyn
Summary: Neighborhood-level social vulnerability is associated with poorer surgical outcomes in pediatric tonsillectomy, leading to higher rates of postoperative complications and readmissions. This finding suggests the importance of community-based interventions in improving surgical outcomes.
Article
Regional & Urban Planning
Sergio Pena
Summary: This analysis explores the state of planning education in Mexico, finding that planning programs are still largely rooted in rational models and need to strengthen their curricula with more valuable communicative skills in a postmodern society.
JOURNAL OF PLANNING EDUCATION AND RESEARCH
(2023)
Article
Behavioral Sciences
Edna C. Cieslik, Markus Ullsperger, Martin Gell, Simon B. Eickhoff, Robert Langner
Summary: Previous studies on error processing have primarily focused on the posterior medial frontal cortex, but the role of other brain regions has been underestimated. This study used activation likelihood estimation meta-analyses to explore brain activity related to committing errors and responding successfully in interference tasks. It was found that the salience network and the temporoparietal junction were commonly involved in both correct and incorrect responses, indicating their general involvement in coping with situations that require increased cognitive control. Error-specific convergence was observed in the dorsal posterior cingulate cortex, posterior thalamus, and left superior frontal gyrus, while successful responding showed stronger convergence in the dorsal attention network and lateral prefrontal regions. Underrecruitment of these regions in error trials may reflect failures in activating the appropriate stimulus-response contingencies necessary for successful response execution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2024)