XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

Dendritic Cells Revisited

(2021) Mar Cabeza-Cabrerizo et al.   Annual Review of Immunology

Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH

(2021) Sabine Daemen et al.   Cell Reports

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

(2021) Dominik Pfister et al.   NATURE

Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

(2021) Michael Dudek et al.   NATURE

Dissecting cellular crosstalk by sequencing physically interacting cells

(2020) Amir Giladi et al.   NATURE BIOTECHNOLOGY

Absence of MHC class II on cDC1 dendritic cells triggers fatal autoimmunity to a cross-presented self-antigen

(2020) Christian Wohn et al.   Science Immunology

Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis

(2020) Sophie Tran et al.   IMMUNITY

Transcriptional Networks Driving Dendritic Cell Differentiation and Function

(2020) Stephen L. Nutt et al.   IMMUNITY

Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver

(2020) Anneleen Remmerie et al.   IMMUNITY

Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

(2020) Yunfan Sun et al.   CELL

Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation

(2019) Joachim L. Schultze et al.   IMMUNITY

Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis

(2019) Oliver Krenkel et al.   GUT

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

(2019) Mohsen Malehmir et al.   NATURE MEDICINE

MARS-seq2.0: an experimental and analytical pipeline for indexed sorting combined with single-cell RNA sequencing

(2019) Hadas Keren-Shaul et al.   Nature Protocols

From NASH to HCC: current concepts and future challenges

(2019) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

(2019) Xuelian Xiong et al.   MOLECULAR CELL

CD8+T CELLS REGULATE LIVER INJURY IN OBESITY-RELATED NONALCOHOLIC FATTY LIVER DISEASE

(2019) Denitra A Breuer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

(2019) Qiming Zhang et al.   CELL

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Depletion of CD40 on CD11c+ cells worsens the metabolic syndrome and ameliorates hepatic inflammation during NASH

(2019) Suzanne Aarts et al.   Scientific Reports

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage

(2018) Maria J Perugorria et al.   GUT

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

(2018) Amir Giladi et al.   NATURE CELL BIOLOGY

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

(2018) Mark A. Febbraio et al.   Cell Metabolism

Mouse models of nonalcoholic steatohepatitis Towards optimization of their relevance to human NASH

(2018) Geoff Farrell et al.   HEPATOLOGY

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

(2018) Samira Parhizkar et al.   NATURE NEUROSCIENCE

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

The differential organogenesis and functionality of two liver-draining lymph nodes in mice

(2017) Jiali Yu et al.   JOURNAL OF AUTOIMMUNITY

Murine CD103 + dendritic cells protect against steatosis progression towards steatohepatitis

(2017) Eva-Carina Heier et al.   JOURNAL OF HEPATOLOGY

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

(2017) Keren Bahar Halpern et al.   NATURE

Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis

(2017) Anna M. Diehl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β

(2017) Kevin M. Hart et al.   Science Translational Medicine

The Liver at the Nexus of Host-Microbial Interactions

(2016) Andrew J. Macpherson et al.   Cell Host & Microbe

NKp46+ natural killer cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation in mice

(2016) Annie-Carole Tosello-Trampont et al.   HEPATOLOGY

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

(2016) Martin Guilliams et al.   IMMUNITY

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells

(2016) E. L. Soucie et al.   SCIENCE

Kupffer Cells Undergo Fundamental Changes during the Development of Experimental NASH and Are Critical in Initiating Liver Damage and Inflammation

(2016) D. T. Reid et al.   PLoS One

Neutrophils Play a Crucial Role in the Early Stage of Nonalcoholic Steatohepatitis via Neutrophil Elastase in Mice

(2015) Shufei Zang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

(2015) Shlomi Finkin et al.   NATURE IMMUNOLOGY

Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow

(2015) Andreas Schlitzer et al.   NATURE IMMUNOLOGY

High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers

(2015) Ingmar Mederacke et al.   Nature Protocols

Murine models provide insight to the development of non-alcoholic fatty liver disease

(2015) D. T. Reid et al.   NUTRITION RESEARCH REVIEWS

Dendritic cells and monocyte-derived cells: Two complementary and integrated functional systems

(2015) Andreas Schlitzer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Nonalcoholic fatty liver disease

(2015) Elizabeth M. Brunt et al.   Nature Reviews Disease Primers

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

CD8 + DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3

(2013) C. Seillet et al.   BLOOD

Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice

(2013) Justin R. Henning et al.   HEPATOLOGY

Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics

(2012) Evaggelia Liaskou et al.   HEPATOLOGY

Compensatory dendritic cell development mediated by BATF–IRF interactions

(2012) Roxane Tussiwand et al.   NATURE

Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression

(2011) Jingjing Jiao et al.   HEPATOLOGY

Pathology of the liver in obese and diabetic ob/ob and db/db mice fed a standard or high-calorie diet

(2011) Viviane Trak-Smayra et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE