Review
Integrative & Complementary Medicine
Zeinab Vafaeipour, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: This paper provides an updated review on the effects of turmeric and its constituent, curcumin, on metabolic syndrome (MS). Studies have shown that turmeric and curcumin have beneficial effects on different components of MS, including anti-inflammatory, anti-oxidant, antidiabetic, antihyperlipidemic, anti-obesity, and antihypertensive effects. The findings suggest that turmeric or curcumin may serve as a complementary therapy for MS. However, more clinical trials are needed to confirm these effects.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Article
Agricultural Engineering
Swathi Chintala, Rosalin Laishram, Prithusayak Mondal, Kumaresh Pal, Prudveesh Kantamraju, Srinjoy Ghosh, Kapudeep Karmakar, Hillol Chakdar, Ria Mukhopadhyay, Ramkrishna Sen, Ashok Choudhury, Somnath Mandal, Nandita Sahana
Summary: This study successfully synthesized silver nanoparticles from turmeric rhizome extract using nanotechnology and demonstrated their antifungal properties. The results suggest that SNPTs can inhibit the growth of Rhizoctonia solani and enhance plant innate immunity, enabling resistance against the fungal pathogen.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Analytical
Nhan Trong Le, Nguyen Thuy Hoang, Van Tuong Thi Van, Trieu Phat Dac Nguyen, Ngoc Huyen Thi Chau, Nguyen Thao Nguyen Le, Hien Bich Thi Le, Huong Thanh Phung, Hoai Thi Nguyen, Hien Minh Nguyen
Summary: This study used deep eutectic solvents (DESs) and surfactant solvents (SSs) to extract curcumin from turmeric residues (TRs). Choline chloride-propylene glycol (ChCl-Pro) showed the highest yield among the solvents used. The optimized extraction conditions achieved a curcumin yield of 54.2 mg g(-1), which was 1.31 times higher than using methanol as a solvent. The recovered curcumin exhibited antioxidant and acetylcholinesterase (AChE) inhibitory activities.
ANALYTICAL METHODS
(2022)
Article
Plant Sciences
Amena Ali, Abuzer Ali, Abu Tahir, Md. Afroz Bakht, Salahuddin, Mohamed Jawed Ahsan
Summary: Cancer, as the second leading cause of death globally in 2020, has led to nearly 10 million deaths and 19.3 million new cases. Curcumin analogs are increasingly being recognized as promising anticancer agents. In this study, three curcumin analogs showed efficient binding to EGFR and demonstrated superior antiproliferative activity compared to curcumin and gefitinib, with compound 3c exhibiting the most significant interaction and inhibition against leukemia cells. These curcumin analogs have the potential to advance cancer drug discovery efforts.
Article
Food Science & Technology
Gal Slacek, Petra Kotnik, Azra Osmic, Vesna Postruznik, Zeljko Knez, Matjaz Finsgar, Masa Knez Marevci
Summary: This study investigated the chemical components and health benefits of turmeric using different extraction methods. Supercritical extracts had the highest phenolic content, while Soxhlet extracts had the highest proanthocyanidin content. UAE and supercritical extracts showed the highest antioxidant potential. Additionally, the study confirmed that turmeric, especially curcumin, is an excellent source of antioxidants that play a crucial role in reducing cellular stress by neutralizing free radicals.
Article
Chemistry, Multidisciplinary
Amjad Hussain, Faisal Attique, Syed Ali Raza Naqvi, Akbar Ali, Muhammad Ibrahim, Hidayat Hussain, Fatiqa Zafar, Rana Saqib Iqbal, Muhammad Adnan Ayub, Mohammed A. Assiri, Muhammad Imran, Shaheed Ullah
Summary: In this study, a nanoformulation of Curcuma longa L. plant extract was prepared to enhance its dissolution potential and biological activities. The nanosuspensions were formulated using different stabilizers, with sodium lauryl sulfate (SLS) showing the best results. The optimized nanosuspension had an average particle size of 308.2 nm and a dissolution rate of 192.32 μg/mL at pH = 7.
Article
Biochemistry & Molecular Biology
Michaela Zeiner, Monika Soltic, Ivan Nemet, Iva Juranovic Cindric
Summary: Turmeric, known for its antioxidant, anti-inflammatory, and antiseptic properties, has a rich nutritional composition that makes it useful in both cooking and medicine. The study examined the elemental composition of turmeric, finding variations between samples due to factors such as origin, production procedures, and harvesting year.
Article
Agronomy
Kylie Tavares, Emilie Kirk, Sharon Motomura-Wages, Justin Calpito, Jon-Paul Bingham, Amjad A. Ahmad, Kevin Flanagan, Jensen Uyeda, Michael B. Kantar, Theodore J. K. Radovich
Summary: Turmeric and its constituent curcuminoid compounds have been traditionally used for their medicinal properties. Recent studies have confirmed their anti-inflammatory, antioxidant, and anticarcinogenic properties. Our research in Hawaii suggests that turmeric yield is influenced by genotype and environmental factors, with suboptimal temperatures at high elevations impacting yield. However, high yielding turmeric varieties show adaptability across diverse environments, but further evaluations are needed in non-optimal environments and high pest pressure areas.
Review
Chemistry, Medicinal
Bibi Marjan Razavi, Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
Summary: Turmeric and its active constituent, curcumin, possess anti-inflammatory, antinociceptive, and antioxidant effects, making them potentially effective in preventing and treating inflammatory disorders and pain. While literature and patents support their clinical application, further high-quality studies are needed to establish their clinical efficacy.
PHYTOTHERAPY RESEARCH
(2021)
Article
Agricultural Engineering
B. S. Harish, K. Umesha, R. Venugopalan, B. N. Maruthi Prasad
Summary: Turmeric grown under different photo-selective nets and sprayed with different elicitors showed differences in growth, yield, and quality. The yellow net had a positive impact on root and rhizome yield, while the blue net had a positive impact on chlorophyll content and curcuminoid content.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Matteo Perini, Silvia Pianezze, Luca Ziller, Roberto Larcher, Roberto Pace
Summary: Curcuminoid complex, a popular natural antioxidant, is threatened by the proliferation of counterfeit products containing synthetic curcuminoids. The addition of synthetic curcuminoids in correct ratios is difficult to detect, increasing the need to identify this fraudulent practice.
Article
Biochemistry & Molecular Biology
Hai Thanh Nguyen, Siyuan Wu, Tomoki Ootawa, Hieu Chi Nguyen, Hong Thi Tran, Pitchaya Pothinuch, Hang Thi Thu Pham, Anh Thi Hong Do, Hao Thanh Hoang, Md. Zahorul Islam, Atsushi Miyamoto, Ha Thi Thanh Nguyen
Summary: Heat treatment can alter the therapeutic effects of turmeric. Dark-roasted turmeric has weaker antibacterial properties and reduced curcumin contents, total polyphenol values, and antioxidant activities. Non-roasting or light-roasting is more suitable for processing turmeric materials for bacterial infections.
Article
Chemistry, Applied
Verena Huber, Laurie Muller, Pierre Degot, Didier Touraud, Werner Kunz
Summary: A choline chloride + lactic acid (1:1) NADES was used to enhance the solubility and extraction power of curcumin in ethanol/triacetin mixtures. The ternary system showed significant nanostructures and a twofold increase in curcumin solubility, enabling more extraction cycles with less solvent required to achieve the same yield.
Article
Food Science & Technology
Elok Zubaidah, Ike Susanti, Hidayat Sujuti, Erryana Martati, Aldilla Putri Rahayu, Ignatius Srianta, Ihab Tewfik
Summary: This study investigates the hepatoprotective activity of fermented turmeric kombucha compared to turmeric essence beverage. The presence of bioactive compounds was detected in both turmeric kombucha and turmeric essence beverages. In vivo tests on mice showed that fermented turmeric kombucha had a greater hepatoprotective effect through the production of new bioactive compounds.
Article
Biochemistry & Molecular Biology
Folake Idowu-Adebayo, Mary J. Toohey, Vincenzo Fogliano, Anita R. Linnemann
Summary: Adding turmeric to zobo drink can enhance the content of vitamins, polyphenols, and minerals, improving the antioxidant and nutritional quality of the drink. Consuming turmeric-fortified zobo can contribute significantly to the daily recommended intake of iron and zinc.
Article
Immunology
Zahra Alizadeh, Pooya Omidnia, Farag M. A. Altalbawy, Gamal A. Gabr, Rasha Fadhel Obaid, Narges Rostami, Saeed Aslani, Aliehsan Heidari, Hamed Mohammadi
Summary: NK cells, frontline responders, can efficiently combat various diseases and leishmaniasis. Despite lacking antigen-specific receptors, NK cells can selectively recognize pathogens through the activation of receptors and their effector functions. This review summarizes the evidence supporting NK cells' role in controlling leishmaniasis and discusses Leishmania parasites' strategies in inhibiting NK cell functions.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Zhiyang Zhang, Farag M. A. Altalbawy, Mohammed Al-Bahrani, Yassine Riadi
Summary: This paper investigates a CHP-based multi-energy microgrid to address the issue of increased Earth's temperature due to burning of conventional energy resources. The proposed system aims to meet energy demand through heating, cooling, and electricity carriers while reducing operation and emission costs. The inclusion of a power-to-gas (P2G) technology helps minimize emissions and improve system efficiency. Uncertainties arising from various parameters are addressed using a scenario-based risk assessment approach (p-robust optimization).
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Article
Chemistry, Medicinal
Walaa Yehia Abdelzaher, Michel De Waard, Alyaa Abdelfattah Abdelmonaem, Dalia Mohamed Ali, Nashwa Fathy Gamal El-Tahawy, Rehab Ahmed Rifaai, Hatem A. Mohamed, Kareem Shaheen, Mohamed Ahmed Zeen El-Din, Nermeen N. Welson, Shereen ELsayed Tawfeek, Gaber El-Saber Batiha, Asmaa Mohamed Abdel-Aziz
Summary: The present experiment aimed to identify the potential protective role of empagliflozin (EMPA) on haloperidol (HAL)-induced ovarian damage in female rats because of its anti-inflammatory, antioxidant, and antiapoptotic effects. The results showed that EMPA significantly alleviated HAL-induced ovarian toxicity by modulating the Sirt-1/Hsp70/TNF-alpha/caspase-3 signaling pathway.
Editorial Material
Infectious Diseases
Jaffar A. Al-Tawfiq, Hitesh Chopra, Kuldeep Dhama, Ranjit Sah, Patricia Schlagenhauf, Ziad A. Memish
NEW MICROBES AND NEW INFECTIONS
(2023)
Review
Surgery
Jatin Chhabra, Hitesh Chopra, Rakesh Pahwa, Neha Raina, Karan Wadhwa, Swati Saini, Poonam Negi, Madhu Gupta, Inderbir Singh, Harish Dureja, Talha Bin Emran
Summary: Wounds are a significant health concern and a major cost to healthcare systems. Nanotechnological advances, especially nanoemulsions, have attracted attention for wound therapy due to their stability and bioavailability. Nanotechnology provides benefits in wound healing such as improved skin permeation and controlled release. This article reviews recent research advancements on the utilization of nanoemulsions in wound treatment.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Letter
Surgery
Hitesh Chopra, Om Prakash Priyanka, Om Prakash B. Choudhary, Talha Emran
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Review
Medicine, General & Internal
Yashendra Sethi, Neil Patel, Nirja Kaka, Oroshay Kaiwan, Jill Kar, Arsalan Moinuddin, Ashish Goel, Hitesh Chopra, Simona Cavalu
Summary: Cardiac diseases have become a major global health issue, with increasing prevalence and a shift towards non-infectious diseases. Precision medicine offers new opportunities for individually personalized management of cardiac diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Mai Abdel Haleem Priyanka, Mai Abdel Haleem Abusalah, Hitesh Chopra, Abhilasha Sharma, Suhad Asad Mustafa, Om Prakash Choudhary, Manish Sharma, Manish Dhawan, Rajiv Khosla, Aanchal Loshali, Ankush Sundriyal, Jyoti Saini
Summary: The field of nanotechnology has revolutionized global efforts in fighting infectious diseases with the development of nanovaccines, which are composed of nanoparticles that stimulate the host's immune system and possess delivery and adjuvant properties. Nanovaccines have the potential to promote rapid and long-lasting immunity, and they offer benefits such as site-specific antigen delivery and reduced adverse effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Sabrean Farhan Jawad, Farag M. A. Altalbawy, Radhwan M. Hussein, Ali Abdulhussain Fadhil, Mohammed Abed Jawad, Rahman S. Zabibah, Tasneem Younus Taraki, Chakrabhavi Dhananjaya Mohan, Kanchugarakoppal S. Rangappa
Summary: The hypoxic environment in solid tumors is closely related to various tumor-promoting processes such as cell proliferation, epithelial-mesenchymal transition (EMT), angiogenesis, metabolic reprogramming, therapeutic resistance, and metastasis. The transcription factor HIF-1a is responsible for mediating these effects by regulating the expression of specific genes. In this article, the role of non-coding RNAs (ncRNAs) in modulating the stability and expression of HIF-1a is critically discussed, along with their potential as targets for cancer treatment.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Cardiac & Cardiovascular Systems
Manasa Kanithi, Lata Kumari, Keerthika Yalakaturi, Kavita Munjal, Santhoshkumar Jimitreddy, Mounika Kandamuri, Phanigreeshma Veeramachineni, Hitesh Chopra, Sunil Junapudi
Summary: Cardiovascular diseases are a major cause of death and morbidity worldwide. Nanoparticles and nanomaterials are increasingly being used as therapeutic and diagnostic modalities in the field of biomedicine. They can interact with the cardiovascular system in multiple ways, impacting cardiac physiology and cellular death. However, the use of nanoparticles can also lead to cardiotoxicity by increasing reactive oxidative species.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Editorial Material
Orthopedics
Hitesh Chopra, Kavita Munjal, Vinod Kumar Gauttam, Shabana Bibi, Partha Biswas
INTERNATIONAL JOURNAL OF SURGERY OPEN
(2023)
Letter
Medicine, General & Internal
Neeraj Gajwani, Kamna Rawat, Akshita Sharma, Mahesh Rachamalla, Niraj K. K. Jha, Hitesh Chopra, Kuldeep Dhama, Talha B. B. Emran
ANNALS OF MEDICINE AND SURGERY
(2023)
Letter
Medicine, General & Internal
Hitesh Chopra, Muhammad S. Khan, Simona Cavalu, Pradipta R. Rauta, Kuldeep Dhama, Talha B. Emran
ANNALS OF MEDICINE AND SURGERY
(2023)
Article
Chemistry, Analytical
Basim Al-Qargholi, F. Al-dolaimy, Farag M. A. Altalbawy, Abed J. Kadhim, Ali Hashiem Alsaalamy, Muath Suliman, Ahmed Hussien R. Abbas
Summary: This study developed a DNA biosensor for the detection of pemigatinib, with low detection limit and good selectivity. The interaction between pemigatinib and DNA was revealed using electrochemical techniques and molecular docking.
ANALYTICAL METHODS
(2023)