Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazole-2-one Scaffold as a Novel NLRP3 Inhibitor
出版年份 2021 全文链接
标题
Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazole-2-one Scaffold as a Novel NLRP3 Inhibitor
作者
关键词
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出版物
MOLECULES
Volume 26, Issue 13, Pages 3975
出版商
MDPI AG
发表日期
2021-06-29
DOI
10.3390/molecules26133975
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes
- (2021) Meenakshi Sharma et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- NLRP3 inflammasome in cardiovascular diseases: Pathophysiological and pharmacological implications
- (2021) Carolina Pellegrini et al. MEDICINAL RESEARCH REVIEWS
- Diagnosis and Management of the Cryopyrin-Associated Periodic Syndromes (CAPS): What Do We Know Today?
- (2021) Tatjana Welzel et al. Journal of Clinical Medicine
- Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities
- (2021) Zhu Liang et al. Cell Communication and Signaling
- NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages
- (2021) Yuhua Shi et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- The Role of the Inflammasome in Neurodegenerative Diseases
- (2021) Federica Piancone et al. MOLECULES
- NLRP3 inflammasome in cancer and metabolic diseases
- (2021) Bhesh Raj Sharma et al. NATURE IMMUNOLOGY
- Neurodegenerative Disease and the NLRP3 Inflammasome
- (2021) Jonathan A. Holbrook et al. Frontiers in Pharmacology
- Regulation of the NLRP3 Inflammasome by Post-Translational Modifications and Small Molecules
- (2021) Jin Kyung Seok et al. Frontiers in Immunology
- NLRP3 Inflammasome at the Interface of Inflammation, Endothelial Dysfunction, and Type 2 Diabetes
- (2021) Ilona M. Gora et al. Cells
- An update on the regulatory mechanisms of NLRP3 inflammasome activation
- (2021) Seungwha Paik et al. Cellular & Molecular Immunology
- The NLRP3 inflammasome: an emerging therapeutic target for chronic pain
- (2021) Ruixiang Chen et al. Journal of Neuroinflammation
- Techniques to Study Inflammasome Activation and Inhibition by Small Molecules
- (2021) Diego Angosto-Bazarra et al. MOLECULES
- Inflammasomes in dendritic cells: Friend or foe?
- (2021) Lukas Hatscher et al. IMMUNOLOGY LETTERS
- Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis
- (2020) Kun Wang et al. CELL
- Toward targeting inflammasomes: insights into their regulation and activation
- (2020) Shelbi Christgen et al. CELL RESEARCH
- Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease
- (2020) Antonio Abbate et al. CIRCULATION RESEARCH
- Cellular Models and Assays to Study NLRP3 Inflammasome Biology
- (2020) Giovanni Zito et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Multifactorial Activation of NLRP3 Inflammasome: Relevance for a Precision Approach to Atherosclerotic Cardiovascular Risk and Disease
- (2020) Andrea Baragetti et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies
- (2020) Danlin Liu et al. CLINICAL SCIENCE
- ATP-Binding and Hydrolysis in Inflammasome Activation
- (2020) Christina F. Sandall et al. MOLECULES
- Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro
- (2020) Anna Gritsenko et al. Frontiers in Immunology
- Recent insights into the regulatory networks of NLRP3 inflammasome activation
- (2020) Alexander N. R. Weber et al. JOURNAL OF CELL SCIENCE
- Inhibiting the NLRP3 Inflammasome
- (2020) Lina Y. El-Sharkawy et al. MOLECULES
- Application of immobilized ATP to the study of NLRP inflammasomes
- (2019) Kuo-Chieh Liao et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- MCC950 closes the active conformation of NLRP3 to an inactive state
- (2019) Ana Tapia-Abellán et al. Nature Chemical Biology
- The NLRP3 inflammasome as pharmacological target
- (2019) Carlo Marchetti JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
- (2019) Humayun Sharif et al. NATURE
- Targeting the NLRP3 inflammasome in inflammatory diseases
- (2018) Matthew S. J. Mangan et al. NATURE REVIEWS DRUG DISCOVERY
- Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming
- (2018) Jack P. Green et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Development of covalent NLRP3 inflammasome inhibitors: Chemistry and biological activity
- (2018) Massimo Bertinaria et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Discovering New Casein Kinase 1d Inhibitors with an Innovative Molecular Dynamics Enabled Virtual Screening Workflow
- (2018) Simone Sciabola et al. ACS Medicinal Chemistry Letters
- NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway
- (2018) Iva Hafner-Bratkovič et al. Nature Communications
- A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-clinical Model of Bowel Inflammation
- (2018) Carolina Pellegrini et al. Frontiers in Pharmacology
- Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease
- (2017) Mattia Cocco et al. JOURNAL OF MEDICINAL CHEMISTRY
- MolProbity: More and better reference data for improved all-atom structure validation
- (2017) Christopher J. Williams et al. PROTEIN SCIENCE
- Allosteric Communication Networks in Proteins Revealed through Pocket Crosstalk Analysis
- (2017) Giuseppina La Sala et al. ACS Central Science
- Design, Synthesis, and Evaluation of Acrylamide Derivatives as Direct NLRP3 Inflammasome Inhibitors
- (2016) Mattia Cocco et al. ChemMedChem
- NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
- (2016) Yuan He et al. NATURE
- Mechanism and Regulation of NLRP3 Inflammasome Activation
- (2016) Yuan He et al. TRENDS IN BIOCHEMICAL SCIENCES
- Inflammasomes: mechanism of action, role in disease and therapeutics
- (2015) Haitao Guo et al. NATURE MEDICINE
- BioGPS: Navigating biological space to predict polypharmacology, off-targeting, and selectivity
- (2015) Lydia Siragusa et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Electrophilic Warhead-Based Design of Compounds Preventing NLRP3 Inflammasome-Dependent Pyroptosis
- (2014) Mattia Cocco et al. JOURNAL OF MEDICINAL CHEMISTRY
- K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
- (2013) Raúl Muñoz-Planillo et al. IMMUNITY
- Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation
- (2013) M. E. Heid et al. JOURNAL OF IMMUNOLOGY
- Magnesium Ion–Water Coordination and Exchange in Biomolecular Simulations
- (2012) Olof Allnér et al. Journal of Chemical Theory and Computation
- Critical role for calcium mobilization in activation of the NLRP3 inflammasome
- (2012) T. Murakami et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure and function of the AAA+ nucleotide binding pocket
- (2011) Petra Wendler et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Tautomer Enumeration and Stability Prediction for Virtual Screening on Large Chemical Databases
- (2009) Francesca Milletti et al. Journal of Chemical Information and Modeling
- Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
- (2008) Veit Hornung et al. NATURE IMMUNOLOGY
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