Neurosteroids: Structure-Uptake Relationships and Computational Modeling of Organic Anion Transporting Polypeptides (OATP)1A2

Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

(2021) Magdalena Markowicz-Piasecka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amino-terminal region of human organic anion transporting polypeptide 1B1 dictates transporter stability and substrate interaction

(2019) Xuyang Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs)

(2019) Johanna Huttunen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A molecular approach in drug development for Alzheimer’s disease

(2018) Snezana Agatonovic-Kustrin et al.   BIOMEDICINE & PHARMACOTHERAPY

A pharmacoeconomic evaluation of cholinesterase inhibitors and memantine for the treatment of Alzheimer’s disease

(2018) Anees Shajhan Ebrahem et al.   EXPERT OPINION ON PHARMACOTHERAPY

A Practical and Efficient Stereoselective Synthesis of (S)-Rivastigmine and (R)-Rivastigmine

(2018) Yong-Gang Hua et al.   ChemistrySelect

Classics in Chemical Neuroscience: Donepezil

(2018) James T. Brewster et al.   ACS Chemical Neuroscience

Strong Inhibitory Effect, Low Cytotoxicity and High Plasma Stability of Steroidal Inhibitors of N-Methyl-D-Aspartate Receptors With C-3 Amide Structural Motif

(2018) Santosh Kumar Adla et al.   Frontiers in Pharmacology

Physicochemical and biological properties of novel amide-based steroidal inhibitors of NMDA receptors

(2017) Santosh Kumar Adla et al.   STEROIDS

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

(2015) Edward Harder et al.   Journal of Chemical Theory and Computation

Genetic Polymorphisms and Function of the Organic Anion-Transporting Polypeptide 1A2 and Its Clinical Relevance in Drug Disposition

(2015) Yinhui Zhou et al.   PHARMACOLOGY

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion

(2014) Douglas B. Kell et al.   Frontiers in Pharmacology

Involvement of the GluN2A and GluN2B Subunits in Synaptic and Extrasynaptic N -methyl-d-aspartate Receptor Function and Neuronal Excitotoxicity

(2013) Xianju Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors

(2013) Sandra I. Mota et al.   NEUROPHARMACOLOGY

Impact of Genetic Variation in OATP Transporters to Drug Disposition and Response

(2012) Inna Y. Gong et al.   Drug Metabolism and Pharmacokinetics

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only

(2011) Douglas B. Kell et al.   DRUG DISCOVERY TODAY

Organic Anion Transporter 3 Mediates the Efflux Transport of an Amphipathic Organic Anion, Dehydroepiandrosterone Sulfate, across the Blood-Brain Barrier in Mice

(2011) M. Miyajima et al.   DRUG METABOLISM AND DISPOSITION

Glutamate Receptor Subtypes Mediating Synaptic Activation of Prefrontal Cortex Neurons: Relevance for Schizophrenia

(2011) D. C. Rotaru et al.   JOURNAL OF NEUROSCIENCE

Neurosteroid modulation of N-methyl-d-aspartate receptors: Molecular mechanism and behavioral effects

(2011) Miloslav Korinek et al.   STEROIDS

Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3

(2010) H Glaeser et al.   BRITISH JOURNAL OF PHARMACOLOGY

Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration

(2010) Nicole Ducharme et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identifying and Characterizing Binding Sites and Assessing Druggability

(2009) Thomas A. Halgren   Journal of Chemical Information and Modeling

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

(2008) Paul D. Dobson et al.   NATURE REVIEWS DRUG DISCOVERY