Article
Medicine, Research & Experimental
Wei-Xia Peng, Pei-Xiang He, Li-Jun Liu, Ting Zhu, Ya-Qin Zhong, Lin Xiang, Ke Peng, Jing-Jin Yang, Guang-Da Xiang
Summary: The study found that the long non-coding RNA GAS5 plays a crucial role in wound healing in diabetic foot ulcers (DFUs) by accelerating wound healing through activating the HIF1A/VEGF pathway. GAS5 interacts with TAF15 to facilitate the expression of HIF1A, contributing to its functions in DFUs.
LABORATORY INVESTIGATION
(2021)
Article
Pharmacology & Pharmacy
Bin Tu, Kai Song, Yang Zhou, He Sun, Zhi-Yan Liu, Li-Chan Lin, Ji-Fei Ding, Ji-Ming Sha, Yan Shi, Jing-Jing Yang, Rui Li, Ye Zhang, Jian-Yuan Zhao, Hui Tao
Summary: This study found that dysregulated mitochondrial fission plays a role in cardiac fibrosis, leading to proliferation and migration of cardiac fibroblasts. The researchers discovered that increased expression of METTL3 gene causes excessive mitochondrial fission, promoting fibroblast proliferation and migration, thus aggravating cardiac fibrosis. Inhibiting the expression of METTL3 gene can suppress mitochondrial fission, reduce fibroblast proliferation and migration, and improve cardiac fibrosis.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Genetics & Heredity
Huanhou Su, Jingzhou Xie, Lijing Wen, Shunyi Wang, Sishuo Chen, Jiangchao Li, Cuiling Qi, Qianqian Zhang, Xiaodong He, Lingyun Zheng, Lijing Wang
Summary: The study constructed a ceRNA network associated with renal fibrosis, revealing that Gas5 may regulate extracellular Fn1 deposition by targeting the transcription factor Creb5. This provides a theoretical basis for the ceRNA regulation mechanism of Gas5 and offers experimental evidence supporting Gas5 targeting in the treatment of renal fibrosis.
Article
Medicine, Research & Experimental
Yuqian Guo, Guoxing Li, Lei Gao, Xiaocheng Cheng, Liyou Wang, Yuhong Qin, Dongying Zhang
Summary: In the mouse model of renal fibrosis induced by unilateral ureteric obstruction, deficiency in lncRNA Gas5 exacerbates renal fibrosis, leading to more severe fibrosis and collagen deposition in the obstructed kidney.
Article
Cell Biology
Yingchun Zhu, Fangfang Zha, Bo Tang, Ting-Ting Ji, Xiao-Ying Li, Linhong Feng, Shou-Jun Bai
Summary: The study found that high glucose-induced circ_0125310 promotes the progression of diabetic nephropathy by regulating miR-422a and the IGF1R/p38 axis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Davide Viggiano
Summary: Diabetes mellitus causes kidney damage progressing to end-stage kidney disease. The two forms of diabetes have different patterns of kidney damage, necessitating analysis of metabolites and hormones, as well as studying differential pharmacological treatments, to understand histopathological patterns of the kidneys and their responses to SGLT2 inhibitors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Mathematical & Computational Biology
Yunyun Zhao, Guanchi Yan, Jia Mi, Guoqiang Wang, Miao Yu, Di Jin, Xiaolin Tong, Xiuge Wang
Summary: By conducting a systematic review and computational analysis of lncRNA in diabetic kidney disease (DKD), this study identified several dysregulated lncRNAs associated with the disease and determined their involvement in disease-related signal pathways.
COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
He Sun, Tong Chen, Xin Li, Yonghong Zhu, Shuang Zhang, Ping He, Yali Peng, Qiuling Fan
Summary: This study investigates the diagnostic value of serum lncRNA GAS5 and miR-21 in patients with T2DM and DN, and suggests that miR-21 may be a more accurate serum biomarker for early screening of DN patients.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Biology
Tingwei Peng, Mingchuan Liu, Lang Hu, Dong Guo, Di Wang, Bingchao Qi, Gaotong Ren, Chenchen Hu, Feng Zhang, Hyung J. Chun, Liqiang Song, Jianqiang Hu, Yan Li
Summary: This study demonstrates that LncRNA Airn plays a role in preventing cardiac fibrosis in diabetic heart through the IMP2-p53 axis, in an m6A-dependent manner. It suggests that LncRNA Airn could be a promising therapeutic target for cardiac fibrosis in diabetic cardiomyopathy.
Article
Biochemistry & Molecular Biology
Min Wang, Xin Chen, Henglu Zhang, Lanlan Li, Yang Xu, Weiping Lu, Yibing Lu
Summary: This study reveals that ENSMUST00000147869 can inhibit the proliferation and fibrosis of MMCs by regulating Hspa9 and inhibiting its interaction with HMGB1. This finding may provide a molecular marker for diagnosis and a therapeutic target for DN.
Article
Endocrinology & Metabolism
Jiang Xu, Linqing Liu, Lin Gan, Yuanyuan Hu, Ping Xiang, Yan Xing, Jie Zhu, Shandong Ye
Summary: This study demonstrated that BBR can regulate mitochondrial ROS generation by activating the positive feedback loop of C/EBP beta/Gas5/miR-18a-5p, thus exerting therapeutic effects in diabetic nephropathy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Shaoqiang Wang, Pengfei Yi, Na Wang, Min Song, Wenhui Li, Yingying Zheng
Summary: In this study, it was found that TUG1 could inhibit apoptosis mediated by ERS by negatively regulating miR-29c-3p, while miR-29c-3p could increase ERS and decrease the level of SIRT1, resulting in injury to HK-2 cells induced by high glucose.
Article
Cell Biology
Yu-Rui Duan, Bao-Ping Chen, Fang Chen, Su-Xia Yang, Chao-Yang Zhu, Ya-Li Ma, Yang Li, Jun Shi
Summary: The study showed that lncRNA lnc-ISG20 is up-regulated in the glomerular of patients with diabetic nephropathy (DN). Silencing lnc-ISG20 alleviated fibrosis in kidney cells and delayed renal fibrosis in DN mice. The downstream miRNA of lnc-ISG20, miR-486-5p, was found to inhibit NFAT5 expression by binding to its 3'UTR.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Immunology
Hai-Di Li, Yong-Ke You, Bao-Yi Shao, Wei-Feng Wu, Yi-Fan Wang, Jian-Bo Guo, Xiao-Ming Meng, Haiyong Chen
Summary: Diabetic nephropathy is the most common chronic kidney disease, and the activation and transition of resident macrophages play a crucial role in causing renal inflammation and fibrosis. Inhibiting macrophage activation and macrophage-cell interactions may be a promising approach to attenuate diabetic nephropathy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiao Li, Miaomiao Sun, Anran Cheng, Guangying Zheng
Summary: DC is a major ocular complication of diabetes, characterized by EMT of LECs. GAS5 and miR-204-3p are involved in the pathogenic mechanism through regulating migration and EMT of LECs induced by HG. The dysregulation of GAS5 impacts lens epithelial cell migration and EMT under HG conditions via the miR-204-3p/TGFBR1 axis.
LABORATORY INVESTIGATION
(2022)
