Redox metabolism: ROS as specific molecular regulators of cell signaling and function

Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells

(2021) Ratnasekhar Ch et al.   Nature Communications

The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling

(2021) Kashi Raj Bhattarai et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The phosphorylation switch that regulates ticking of the circadian clock

(2021) Rajesh Narasimamurthy et al.   MOLECULAR CELL

Structural basis for a complex I mutation that blocks pathological ROS production

(2021) Zhan Yin et al.   Nature Communications

Mitochondrial redox and TCA cycle metabolite signaling in the heart

(2021) Ana Vujic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovering the landscape of protein modifications

(2021) E. Keith Keenan et al.   MOLECULAR CELL

The Human 2-Cys Peroxiredoxins form Widespread, Cysteine-Dependent- and Isoform-Specific Protein-Protein Interactions

(2021) Loes van Dam et al.   Antioxidants

Redox regulation of the insulin signalling pathway

(2021) Claudia Lennicke et al.   Redox Biology

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

(2020) Haopeng Xiao et al.   CELL

Spatial and temporal alterations in protein structure by EGF regulate cryptic cysteine oxidation

(2020) Jessica B. Behring et al.   Science Signaling

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

Translational Regulations in Response to Endoplasmic Reticulum Stress in Cancers

(2020) Manon Jaud et al.   Cells

Redox signalling and ageing: insights from Drosophila

(2020) Claudia Lennicke et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Effects of Oxidative Stress on Protein Translation: Implications for Cardiovascular Diseases

(2020) Arnab Ghosh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of the ERO1-PDI interaction in oxidative protein folding and disease

(2020) Andrea G. Shergalis et al.   PHARMACOLOGY & THERAPEUTICS

Crystal structure of sulfonic peroxiredoxin Ahp1 in complex with thioredoxin Trx2 mimics a conformational intermediate during the catalytic cycle

(2020) Fu-Ming Lian et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Pathophysiology of Type 2 Diabetes Mellitus

(2020) Unai Galicia-Garcia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

The correlation of IRE1α oxidation with Nox4 activation in aging-associated vascular dysfunction

(2020) Hwa-Young Lee et al.   Redox Biology

Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer

(2020) Janine M. DeBlasi et al.   Cancers

Crosstalk between metabolism and circadian clocks

(2019) Hans Reinke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A potassium channel β-subunit couples mitochondrial electron transport to sleep

(2019) Anissa Kempf et al.   NATURE

Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease

(2019) Lismont et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bicarbonate is essential for protein tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades

(2019) Markus Dagnell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of translational control by eIF2 phosphorylation

(2019) Tomas Adomavicius et al.   Nature Communications

Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks

(2019) Jian-Fei Pei et al.   NATURE CELL BIOLOGY

Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

(2019) Carlos Henríquez-Olguin et al.   Nature Communications

Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation

(2019) Reiko Matsui et al.   ANTIOXIDANTS & REDOX SIGNALING

Defining a metabolic landscape of tumours: genome meets metabolism

(2019) Chandan Seth Nanda et al.   BRITISH JOURNAL OF CANCER

Enhanced hyperoxidation of peroxiredoxin 2 and peroxiredoxin 3 in the presence of bicarbonate/CO2

(2019) Alexander V. Peskin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Developmental ROS individualizes organismal stress resistance and lifespan

(2019) Daphne Bazopoulou et al.   NATURE

Global redox proteome and phosphoproteome analysis reveals redox switch in Akt

(2019) Zhiduan Su et al.   Nature Communications

Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities

(2018) Juan I. Sbodio et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein Promiscuity in H2O2 Signaling

(2018) David Young et al.   ANTIOXIDANTS & REDOX SIGNALING

Hyperoxidation of Peroxiredoxins: Gain or Loss of Function?

(2018) Elizabeth A. Veal et al.   ANTIOXIDANTS & REDOX SIGNALING

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Redox clocks: Time to rethink redox interventions

(2018) Andras D. Nagy et al.   FREE RADICAL BIOLOGY AND MEDICINE

Maintaining a Healthy Proteome during Oxidative Stress

(2018) Dana Reichmann et al.   MOLECULAR CELL

Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions

(2018) György Csordás et al.   TRENDS IN CELL BIOLOGY

Oxidation of Atg3 and Atg7 mediates inhibition of autophagy

(2018) Karen Frudd et al.   Nature Communications

Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species

(2018) Ulrike Topf et al.   Nature Communications

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

(2018) Bernadette Carroll et al.   Nature Communications

Crystal structures of pan-IDH inhibitor AG-881 in complex with mutant human IDH1 and IDH2

(2018) Rui Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

(2018) Elizabeth C Hinchy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes

(2018) Kimberly J Nelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin

(2018) Yuichiro Mita et al.   Scientific Reports

Revisiting the role of metabolism during development

(2018) Hidenobu Miyazawa et al.   DEVELOPMENT

Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila

(2018) Matthew CW Oswald et al.   eLife

Glyceraldehyde-3-phosphate dehydrogenase from Citrobacter sp. S-77 is post-translationally modified by CoA (protein CoAlation) under oxidative stress

(2018) Kohsei Tsuji et al.   FEBS Open Bio

Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer’s disease

(2017) Caterina Branca et al.   HUMAN MOLECULAR GENETICS

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson’s Disease Models

(2017) Chang-Ki Oh et al.   Cell Reports

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

(2017) Ana I. Rojo et al.   Redox Biology

Quantitative biology of hydrogen peroxide signaling

(2017) Fernando Antunes et al.   Redox Biology

The Hallmarks of Cancer from a Redox Perspective

(2016) Marten Hornsveld et al.   ANTIOXIDANTS & REDOX SIGNALING

Crystal structures of human peroxiredoxin 6 in different oxidation states

(2016) Kyung Hee Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Succinate metabolism: a new therapeutic target for myocardial reperfusion injury

(2016) Victoria R. Pell et al.   CARDIOVASCULAR RESEARCH

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Suppressors of Superoxide-H 2 O 2 Production at Site I Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury

(2016) Martin D. Brand et al.   Cell Metabolism

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

(2016) Filippo Scialò et al.   Cell Metabolism

Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype

(2016) Gregg L Semenza   EMBO JOURNAL

The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome

(2016) Sandra Reeg et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dissecting the role of redox signaling in neuronal development

(2016) Daniel A. Bórquez et al.   JOURNAL OF NEUROCHEMISTRY

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Reciprocal Control of the Circadian Clock and Cellular Redox State - a Critical Appraisal

(2016)   MOLECULES AND CELLS

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

(2016) Edward T. Chouchani et al.   NATURE

Atomic structure of the entire mammalian mitochondrial complex I

(2016) Karol Fiedorczuk et al.   NATURE

ROS mediates interferon gamma induced phosphorylation of Src, through the Raf/ERK pathway, in MCF-7 human breast cancer cell line

(2016) Kazem Zibara et al.   Journal of Cell Communication and Signaling

Modulation of MHC class I surface expression in B16F10 melanoma cells by methylseleninic acid

(2016) Claudia Lennicke et al.   OncoImmunology

Oxidative Dimerization of PHD2 is Responsible for its Inactivation and Contributes to Metabolic Reprogramming via HIF-1α Activation

(2016) Gibok Lee et al.   Scientific Reports

Metabolism and Epigenetics

(2015) Ryan Janke et al.   Annual Review of Cell and Developmental Biology

Nrf2 inducer and cncC overexpression attenuates neurodegeneration due to α-synuclein in Drosophila

(2015) Bing Wang et al.   Biochemistry and Cell Biology

Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation

(2015) Annelies Peeters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hydrogen peroxide – production, fate and role in redox signaling of tumor cells

(2015) Claudia Lennicke et al.   Cell Communication and Signaling

The cysteine proteome

(2015) Young-Mi Go et al.   FREE RADICAL BIOLOGY AND MEDICINE

The basics of thiols and cysteines in redox biology and chemistry

(2015) Leslie B. Poole   FREE RADICAL BIOLOGY AND MEDICINE

Circadian Oscillation of Sulfiredoxin in the Mitochondria

(2015) In Sup Kil et al.   MOLECULAR CELL

Suppressors of superoxide production from mitochondrial complex III

(2015) Adam L Orr et al.   Nature Chemical Biology

Circadian redox oscillations and metabolism

(2015) Nikolay B. Milev et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Redox regulation of FoxO transcription factors

(2015) Lars-Oliver Klotz et al.   Redox Biology

Thermodynamic and Structural Characterization of the Specific Binding of Zn(II) to Human Protein DJ-1

(2014) Shinya Tashiro et al.   BIOCHEMISTRY

Nox4: A Hydrogen Peroxide-Generating Oxygen Sensor

(2014) Yukio Nisimoto et al.   BIOCHEMISTRY

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Type 2 diabetes as a redox disease

(2014) James D Watson   LANCET

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling

(2014) Mirko C Sobotta et al.   Nature Chemical Biology

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular chaperones and proteostasis regulation during redox imbalance

(2014) Katerina Niforou et al.   Redox Biology

Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes

(2013) Mohammed Mahidur Rahman et al.   AGING CELL

Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide

(2013) Gerd P. Bienert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery

(2013) Candice E. Paulsen et al.   CHEMICAL REVIEWS

Redox regulation of protein kinases

(2013) Aoife Corcoran et al.   FEBS Journal

Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells

(2013) Bo Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

(2013) J. López-Erauskin et al.   HUMAN MOLECULAR GENETICS

Oxidant Sensing by Reversible Disulfide Bond Formation

(2013) Claudia M. Cremers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox-Dependent Control of FOXO/DAF-16 by Transportin-1

(2013) Marrit Putker et al.   MOLECULAR CELL

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum

(2013) A. M. Benham et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Aconitase post-translational modification as a key in linkage between Krebs cycle, iron homeostasis, redox signaling, and metabolism of reactive oxygen species

(2013) Oleh V. Lushchak et al.   REDOX REPORT

Redox Control of 20S Proteasome Gating

(2012) Gustavo M. Silva et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells

(2012) Reagan M. Jarvis et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inactivation of Pyruvate Dehydrogenase Kinase 2 by Mitochondrial Reactive Oxygen Species

(2012) Thomas R. Hurd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Peroxiredoxins are conserved markers of circadian rhythms

(2012) Rachel S. Edgar et al.   NATURE

Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy

(2012) Weiqin Lu et al.   PLOS BIOLOGY

Effects of peroxisomal catalase inhibition on mitochondrial function

(2012) Paul A. Walton   Frontiers in Physiology

Ero1α Regulates Ca2+ Fluxes at the Endoplasmic Reticulum–Mitochondria Interface (MAM)

(2011) Tiziana Anelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Treatment of doxorubicin-resistant MCF7/Dx cells with nitric oxide causes histone glutathionylation and reversal of drug resistance

(2011) Anastasia de Luca et al.   BIOCHEMICAL JOURNAL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Unraveling the Biological Roles of Reactive Oxygen Species

(2011) Michael P. Murphy et al.   Cell Metabolism

HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress

(2011) Tilman Grune et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk

(2011) Oksana Ivashchenko et al.   MOLECULAR BIOLOGY OF THE CELL

Chemistry and biology of reactive oxygen species in signaling or stress responses

(2011) Bryan C Dickinson et al.   Nature Chemical Biology

Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity

(2011) Candice E Paulsen et al.   Nature Chemical Biology

Regulation of Translation by Hydrogen Peroxide

(2010) Chris M. Grant   ANTIOXIDANTS & REDOX SIGNALING

The Redox Basis of Epigenetic Modifications: From Mechanisms to Functional Consequences

(2010) Anthony R. Cyr et al.   ANTIOXIDANTS & REDOX SIGNALING

Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress

(2010) Ulrike Seifert et al.   CELL

Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI

(2010) Kenji Inaba et al.   EMBO JOURNAL

Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase

(2010) Jaroslaw W. Zmijewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine Function Governs Its Conservation and Degeneration and Restricts Its Utilization on Protein Surfaces

(2010) Stefano M. Marino et al.   JOURNAL OF MOLECULAR BIOLOGY

Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

(2010) Long Chen et al.   LABORATORY INVESTIGATION

Mitochondrial redox metabolism: Aging, longevity and dietary effects

(2010) Melissa M. Page et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis

(2010) Hideaki Kaneto et al.   MEDIATORS OF INFLAMMATION

Oxidative Protein Folding by an Endoplasmic Reticulum-Localized Peroxiredoxin

(2010) Ester Zito et al.   MOLECULAR CELL

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hydrogen peroxide is the major oxidant product of xanthine oxidase

(2009) Eric E. Kelley et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of redox modulation of class II histone deacetylases in mediating pathological cardiac hypertrophy

(2009) Shin-ichi Oka et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity

(2009) Tobias B Dansen et al.   Nature Chemical Biology

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Redox signals in wound healing

(2008) Chandan K. Sen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Discovering mechanisms of signaling-mediated cysteine oxidation

(2008) Leslie B Poole et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE

S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

(2008) Alexi Nott et al.   NATURE

The role of FoxO in the regulation of metabolism

(2008) D N Gross et al.   ONCOGENE

HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment

(2008) C. Colussi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prediction of reversibly oxidized protein cysteine thiols using protein structure properties

(2008) Ricardo Sanchez et al.   PROTEIN SCIENCE

Glutathionylation-triggered conformational changes of glutaredoxin Grx1 from the yeast Saccharomyces cerevisiae

(2008) Jiang Yu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Mitochondrially encoded cysteine predicts animal lifespan

(2007) Bernd Moosmann et al.   AGING CELL