The newly discovered role of endocytosis in artemisinin resistance

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

(2021) Sachel Mok et al.   Nature Communications

Mammalian Deubiquitinating Enzyme Inhibitors Display in Vitro and in Vivo Activity against Malaria Parasites and Potentiate Artemisinin Action

(2021) Nelson V. Simwela et al.   ACS Infectious Diseases

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

(2020) Jakob Birnbaum et al.   SCIENCE

The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation

(2020) Ryan C. Henrici et al.   mBio

Role of Plasmodium falciparum Kelch 13 Protein Mutations in P. falciparum Populations from Northeastern Myanmar in Mediating Artemisinin Resistance

(2020) Faiza Amber Siddiqui et al.   mBio

Experimentally engineered mutations in a ubiquitin hydrolase, UBP-1, modulate in vivo susceptibility to artemisinin and chloroquine in Plasmodium berghei.

(2020) Nelson V. Simwela et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cullin 3 Is Crucial for Pro-B Cell Proliferation, Interacts with CD22, and Controls CD22 Internalization on B Cells

(2020) Sarah J. Meyer et al.   JOURNAL OF IMMUNOLOGY

Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial

(2020) Rob W van der Pluijm et al.   LANCET

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13

(2020) Nina F. Gnädig et al.   PLoS Pathogens

Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance

(2020) Luana C Mathieu et al.   eLife

Plasmodium falciparum Artemisinin Resistance: The Effect of Heme, Protein Damage, and Parasite Cell Stress Response

(2020) Melissa R. Rosenthal et al.   ACS Infectious Diseases

Characterization of putative drug resistant biomarkers in Plasmodium falciparum isolated from Ghanaian blood donors

(2020) Enoch Aninagyei et al.   BMC INFECTIOUS DISEASES

Different Plasmodium falciparum clearance times in two Malian villages following artesunate monotherapy

(2020) Aminatou Kone et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

(2020) Aline Uwimana et al.   NATURE MEDICINE

A lipocalin mediates unidirectional heme biomineralization in malaria parasites

(2020) Joachim M. Matz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endocytosis in Plasmodium and Toxoplasma Parasites

(2020) Tobias Spielmann et al.   TRENDS IN PARASITOLOGY

Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial

(2020) David S. Khoury et al.   TRENDS IN PARASITOLOGY

Structure-Based Identification and Functional Characterization of a Lipocalin in the Malaria Parasite Plasmodium falciparum

(2020) Paul-Christian Burda et al.   Cell Reports

K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair

(2020) Aoli Xiong et al.   Cell Reports

Artemisinin susceptibility in the malaria parasite Plasmodium falciparum: propellers, adaptor proteins and the need for cellular healing

(2020) Colin J Sutherland et al.   FEMS MICROBIOLOGY REVIEWS

Safety and parasite clearance of artemisinin-resistant Plasmodium falciparum infection: A pilot and a randomised volunteer infection study in Australia

(2020) Rebecca E. Watts et al.   PLOS MEDICINE

Syk Kinase Inhibitors Synergize with Artemisinins by Enhancing Oxidative Stress in Plasmodium falciparum-Parasitized Erythrocytes

(2020) Ioannis Tsamesidis et al.   Antioxidants

Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum

(2020) Aabha I. Sharma et al.   PLoS Genetics

Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis

(2019)   BMC Medicine

A Temporizing Solution to “Artemisinin Resistance”

(2019) Jigang Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors

(2019) Wenhu Zhan et al.   JOURNAL OF MEDICINAL CHEMISTRY

An alternative dogma on reduced artemisinin susceptibility: A new shadow from east to west

(2019) Thirumalaisamy P. Velavan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reply to Velavan et al.: Polymorphisms ofpfcoroninin natural populations: Implications for functional significance

(2019) Aabha I. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative structural and evolutionary analyses predict functional sites in the artemisinin resistance malaria protein K13

(2019) Romain Coppée et al.   Scientific Reports

Modification of pfap2μ and pfubp1 Markedly Reduces Ring-Stage Susceptibility of Plasmodium falciparum to Artemisinin In Vitro

(2019) Ryan C. Henrici et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Kelch-like proteins: Physiological functions and relationships with diseases

(2019) Xiaoxian Shi et al.   PHARMACOLOGICAL RESEARCH

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

(2019) Tuo Yang et al.   Cell Reports

Multigenic architecture of piperaquine resistance trait in Plasmodium falciparum

(2019) Miguel Silva et al.   LANCET INFECTIOUS DISEASES

Do fitness costs explain the rapid spread of kelch13-C580Y substitutions conferring artemisinin resistance?

(2018) Shalini Nair et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Remodeling of the malaria parasite and host human red cell by vesicle amplification that induces artemisinin resistance

(2018) Souvik Bhattacharjee et al.   BLOOD

Resistance screening and trend analysis of imported falciparum malaria in NSW, Australia (2010 to 2016)

(2018) Christiane Prosser et al.   PLoS One

Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance

(2018) Laura A. Kirkman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy

(2018) Rebecca S. Lee et al.   Nature Communications

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

(2018) Frances Rocamora et al.   PLoS Pathogens

High-level artemisinin-resistance with quinine co-resistance emerges in P. falciparum malaria under in vivo artesunate pressure

(2018) Rajeev K. Tyagi et al.   BMC Medicine

Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors

(2018) Euna Yoo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Implications of population-level immunity for the emergence of artemisinin-resistant malaria: a mathematical model

(2018) Nick Scott et al.   MALARIA JOURNAL

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

(2018) Jessica L. Bridgford et al.   Nature Communications

Altered expression of K13 disrupts DNA replication and repair in Plasmodium falciparum

(2018) Justin Gibbons et al.   BMC GENOMICS

PfVPS45 Is Required for Host Cell Cytosol Uptake by Malaria Blood Stage Parasites

(2018) Ernst Jonscher et al.   Cell Host & Microbe

Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome

(2018) Stanley C. Xie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model

(2018) Juliana M. Sá et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility

(2018) Allison R. Demas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative pathway to reduced artemisinin susceptibility in Plasmodium falciparum

(2018) Ryan C. Henrici et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient temperature fluctuations severely decrease P. falciparum susceptibility to artemisinin in vitro

(2018) Ryan C. Henrici et al.   International Journal for Parasitology-Drugs and Drug Resistance

Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine

(2018) Duangkamon Loesbanluechai et al.   International Journal for Parasitology-Drugs and Drug Resistance

Partner-Drug Resistance and Population Substructuring of Artemisinin-Resistant Plasmodium falciparum in Cambodia

(2017) Christian M. Parobek et al.   Genome Biology and Evolution

Absence of association between polymorphisms in the K13 gene and the presence of Plasmodium falciparum parasites at day 3 after treatment with artemisinin derivatives in Senegal

(2017) Marylin Madamet et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Multi-omics Based Identification of Specific Biochemical Changes Associated With PfKelch13-Mutant Artemisinin-Resistant Plasmodium falciparum

(2017) Ghizal Siddiqui et al.   JOURNAL OF INFECTIOUS DISEASES

Spread of a single multidrug resistant malaria parasite lineage ( PfPailin ) to Vietnam

(2017) Mallika Imwong et al.   LANCET INFECTIOUS DISEASES

Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia

(2017) Angana Mukherjee et al.   MALARIA JOURNAL

Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisinin–piperaquine in the south of Vietnam

(2017) Ngo Viet Thanh et al.   MALARIA JOURNAL

A genetic system to study Plasmodium falciparum protein function

(2017) Jakob Birnbaum et al.   NATURE METHODS

Emergence of Indigenous Artemisinin-Resistant Plasmodium falciparum in Africa

(2017) Feng Lu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Host immunity toPlasmodium falciparumand the assessment of emerging artemisinin resistance in a multinational cohort

(2017) Ricardo Ataide et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro

(2017) Judith Straimer et al.   mBio

The AP-2 complex has a specialized clathrin-independent role in apical endocytosis and polar growth in fungi

(2017) Olga Martzoukou et al.   eLife

Split dosing of artemisinins does not improve antimalarial therapeutic efficacy

(2017) N. J. White et al.   Scientific Reports

A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile

(2016) Hanafy M. Ismail et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The cryo-EM structure of thePlasmodium falciparum20S proteasome and its use in the fight against malaria

(2016) Hao Li et al.   FEBS Journal

Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study

(2016) Chanaki Amaratunga et al.   LANCET INFECTIOUS DISEASES

Lack of K13 mutations in Plasmodium falciparum persisting after artemisinin combination therapy treatment of Kenyan children

(2016) Julian Muwanguzi et al.   MALARIA JOURNAL

A Worldwide Map ofPlasmodium falciparumK13-Propeller Polymorphisms

(2016) Didier Ménard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasitesPlasmodium falciparum3D7

(2016) Hanafy M. Ismail et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Artemisinin Action and Resistance in Plasmodium falciparum

(2016) Leann Tilley et al.   TRENDS IN PARASITOLOGY

Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites

(2016) Suresh M. Ganesan et al.   Nature Communications

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

(2016) M. Isabel Veiga et al.   Nature Communications

Genome-wide association analysis identifies genetic loci associated with resistance to multiple antimalarials in Plasmodium falciparum from China-Myanmar border

(2016) Zenglei Wang et al.   Scientific Reports

Genomic epidemiology of artemisinin resistant malaria

(2016)   eLife

Altering Antimalarial Drug Regimens May Dramatically Enhance and Restore Drug Effectiveness

(2015) Katherine Kay et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Artemisinin-Resistant Plasmodium falciparum Parasites Exhibit Altered Patterns of Development in Infected Erythrocytes

(2015) Amanda Hott et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Mu Subunit of Plasmodium falciparum Clathrin-Associated Adaptor Protein 2 ModulatesIn VitroParasite Response to Artemisinin and Quinine

(2015) Gisela Henriques et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Eps15 homology domain containing protein of Plasmodium falciparum (PfEHD) associates with endocytosis and vesicular trafficking towards neutral lipid storage site

(2015) Vandana Thakur et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Defining the Morphology and Mechanism of the Hemoglobin Transport Pathway in Plasmodium falciparum-Infected Erythrocytes

(2015) Katharine J. Milani et al.   EUKARYOTIC CELL

Independent Emergence of thePlasmodium falciparumKelch Propeller Domain Mutant Allele C580Y in Guyana

(2015) Stella M. Chenet et al.   JOURNAL OF INFECTIOUS DISEASES

Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites

(2015) Maya A Olshina et al.   MALARIA JOURNAL

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

(2015) Alassane Mbengue et al.   NATURE

Genetic architecture of artemisinin-resistant Plasmodium falciparum

(2015) Olivo Miotto et al.   NATURE GENETICS

Advances in molecular genetic systems in malaria

(2015) Tania F. de Koning-Ward et al.   NATURE REVIEWS MICROBIOLOGY

Artemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa

(2015) Brandyce St. Laurent et al.   Nature Communications

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

(2015) Jigang Wang et al.   Nature Communications

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

(2015) Con Dogovski et al.   PLOS BIOLOGY

Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation

(2014) Frances-Rose Schumacher et al.   BIOCHEMICAL JOURNAL

Directional Selection at the pfmdr1, pfcrt, pfubp1, and pfap2mu Loci of Plasmodium falciparum in Kenyan Children Treated With ACT

(2014) Gisela Henriques et al.   JOURNAL OF INFECTIOUS DISEASES

Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system

(2014) Mehdi Ghorbal et al.   NATURE BIOTECHNOLOGY

Efficient CRISPR-Cas9–mediated genome editing in Plasmodium falciparum

(2014) Jeffrey C Wagner et al.   NATURE METHODS

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dihydroartemisinin–Piperaquine Failure in Cambodia

(2014) David L. Saunders et al.   NEW ENGLAND JOURNAL OF MEDICINE

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

(2014) S. Mok et al.   SCIENCE

Clathrin-Independent Pathways of Endocytosis

(2014) S. Mayor et al.   Cold Spring Harbor Perspectives in Biology

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

(2013) Nectarios Klonis et al.   CURRENT OPINION IN MICROBIOLOGY

Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies

(2013) Benoit Witkowski et al.   LANCET INFECTIOUS DISEASES

Artemisinin resistance in rodent malaria - mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking

(2013) Gisela Henriques et al.   MALARIA JOURNAL

Robust inducible Cre recombinase activity in the human malaria parasitePlasmodium falciparumenables efficient gene deletion within a single asexual erythrocytic growth cycle

(2013) Christine R. Collins et al.   MOLECULAR MICROBIOLOGY

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

(2013) Olivo Miotto et al.   NATURE GENETICS

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Reduced Susceptibility of Plasmodium falciparum to Artesunate in Southern Myanmar

(2013) Myat P. Kyaw et al.   PLoS One

Inducible Knockdown of Plasmodium Gene Expression Using the glmS Ribozyme

(2013) Parichat Prommana et al.   PLoS One

Genome-wide screen identifies new candidate genes associated with artemisinin susceptibility in Plasmodium falciparum in Kenya

(2013) Steffen Borrmann et al.   Scientific Reports

First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

(2012) Joerg J. Moehrle et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study

(2012) Aung Pyae Phyo et al.   LANCET

Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia

(2012) S. Takala-Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Major Genome Region Underlying Artemisinin Resistance in Malaria

(2012) I. H. Cheeseman et al.   SCIENCE

Artemisinin resistance in Plasmodium falciparum: A process linked to dormancy?

(2012) Qin Cheng et al.   International Journal for Parasitology-Drugs and Drug Resistance

Phenotypic Changes in Artemisinin-Resistant Plasmodium falciparum LinesIn Vitro: Evidence for Decreased Sensitivity to Dormancy and Growth Inhibition

(2011) Franka Teuscher et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription

(2011) Sachel Mok et al.   BMC GENOMICS

The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

(2011) Youyou Tu   NATURE MEDICINE

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Artesunate Dose Escalation for the Treatment of Uncomplicated Malaria in a Region of Reported Artemisinin Resistance: A Randomized Clinical Trial

(2011) Delia Bethell et al.   PLoS One

Effects of Artesunate on Parasite Recrudescence and Dormancy in the Rodent Malaria Model Plasmodium vinckei

(2011) Alexis N. LaCrue et al.   PLoS One

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

(2011) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

(2011) S. A. Charman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development and host cell modifications of Plasmodium falciparum blood stages in four dimensions

(2011) Christof Grüring et al.   Nature Communications

Experimental evolution, genetic analysis and genome re-sequencing reveal the mutation conferring artemisinin resistance in an isogenic lineage of malaria parasites

(2010) Paul Hunt et al.   BMC GENOMICS

Digestive-vacuole genesis and endocytic processes in the early intraerythrocytic stages of Plasmodium falciparum

(2010) N. A. Bakar et al.   JOURNAL OF CELL SCIENCE

Artemisinin‐Induced Dormancy inPlasmodium falciparum: Duration, Recovery Rates, and Implications in Treatment Failure

(2010) Franka Teuscher et al.   JOURNAL OF INFECTIOUS DISEASES

Systems survey of endocytosis by multiparametric image analysis

(2010) Claudio Collinet et al.   NATURE

Eps15: a multifunctional adaptor protein regulating intracellular trafficking

(2009) Paul MP van Bergen en Henegouwen   Cell Communication and Signaling

Acquired Immunity to Malaria

(2009) D. L. Doolan et al.   CLINICAL MICROBIOLOGY REVIEWS

Control of Rapsyn Stability by the CUL-3-containing E3 Ligase Complex

(2009) Seunghee Nam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum

(2008) D. A. Elliott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA