Article
Biochemistry & Molecular Biology
Jia Zhang, Ya-Nan Li, Lin-Bo Guo, Jun He, Peng-Hui Liu, Hai-Yan Tian, Wei-Ku Zhang, Jie-Kun Xu
Summary: A phytochemical investigation of the roots of Euphorbia fischeriana Steud. led to the isolation of eleven undescribed gallotannins, fishertannins A-K, together with four known analogues. Fishertannin A, possessing an unusual skeleton, showed the strongest inhibitory activity against alpha-glucosidase. These findings indicate the potential antidiabetic activity of the compounds from E. fischeriana.
Article
Biochemistry & Molecular Biology
Akinsola A. Famuwagun, Adeola M. Alashi, Olasunkanmi S. Gbadamosi, Kehinde A. Taiwo, Durodoluwa Oyedele, Odunayo C. Adebooye, Rotimi E. Aluko
Summary: The study hydrolyzed and fractionated amaranth leaf protein isolate, finding that different protease hydrolyzates and peptide fractions displayed good antioxidant and enzyme inhibitory activities; Different protease hydrolysis can produce hydrolyzates with varying activities, suitable for nutraceutical and functional food applications.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Food Science & Technology
Mengjie Wei, Minyue Tang, Luyu Wang, Xuanxuan Cheng, Yanwen Wu, Jie Ouyang
Summary: The free and bound bioactive extracts from naked oat showed inhibitory effects on amylase and glucosidase activity, reducing starch hydrolysis rates significantly. Ginsenoside Re and soyasaponin Ba had different inhibitory effects on amylase and glucosidase.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Amita Bhadkaria, Nidhi Srivastava, Sameer Suresh Bhagyawant
Summary: This study comprehensively analyzed 60 moth bean accessions from diverse regions in India, focusing on phytochemical and pharmacological attributes. The findings suggest that certain moth bean accessions contain bioactive compounds with potential health benefits, particularly in terms of amino acids, minerals, and antioxidants.
Article
Food Science & Technology
Fengyu Guo, Jie An, Minlong Wang, Weibo Zhang, Chong Chen, Xueying Mao, Siyuan Liu, Pengjie Wang, Fazheng Ren
Summary: In this study, Quercimeritrin was identified as a selective inhibitor of alpha-glucosidase and shown to effectively control postprandial blood glucose in vivo. The results provide insights into using flavone aglycones to improve postprandial blood glucose levels.
Article
Chemistry, Applied
Yi Zhang, Shudong He, Xin Rui, Benjamin K. Simpson
Summary: The study demonstrates the molecular mechanisms of marine-derived peptides in inhibiting multiple enzymes involved in chronic diseases. In silico analyses showed that one peptide could inhibit multiple enzymes by forming specific interactions with their active sites. Peptides with different mechanisms were found to inhibit ACE and α-amylase, while another peptide inhibited ACE, α-amylase, and lipase through direct interactions with catalytic residues.
Article
Agriculture, Multidisciplinary
Ekkarat Tangkhawanit, Sirithon Siriamornpun
Summary: This study found that the bioactive components in soybean residues significantly increased after hot-air drying, with improved antioxidant properties and reduced starch digestion. These findings suggest that soybean residues could be utilized as functional food ingredients.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Agricultural Engineering
Jie Tu, Guanhui Liu, Yinchun Jin, Caiyun Tang, Tong Yao, Jun Zhuo, Qiang Li, Li Liu, Jun Wang
Summary: Different methods were used to treat mulberry leaves and accumulate gamma-aminobutyric acid (GABA), which increased ACE inhibitory activity. Molecular docking showed that GABA interacts with ACE through zinc ion chelation. However, the inhibition of mulberry leaf extract on alpha-glucosidase was not closely related to GABA content.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Plant Sciences
Alev Onder, Ahsen Sevde Cinar, Merve Yuzbasioglu Baran, Ayse Kuruuzum-Uz, Antoaneta Trendafilova
Summary: The phytochemical investigation of the n-hexane extract of Seseli petraeum M. Bieb., a plant growing in northern Turkey, led to the isolation of a new pyranocoumarin and 12 known coumarins. These coumarins exhibited notable inhibitory activity against the alpha-glucosidase enzyme and low inhibitory potential against alpha-amylase.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Plant Sciences
Mohamad Gazali, Odi Jolanda, Amir Husni, Fadzilah Adibah Abd Nurjanah, Fadzilah Adibah Abd Majid, Zuriat, Rina Syafitri
Summary: This study aimed to determine the antidiabetic activity of extracts and fractions from the green seaweed Halimeda tuna. The results showed that the ethyl acetate fraction and methanol extract exhibited strong inhibitory activity against alpha-amylase and alpha-glucosidase. Additionally, these extracts and fractions contained various secondary metabolites that may contribute to their inhibitory activity.
Article
Chemistry, Applied
Qing-Qing Lv, Juan-Juan Cao, Rui Liu, Han-Qing Chen
Summary: Two polysaccharide fractions, WXA-1 and AXA-1, were isolated from wheat bran in this study. Structural analysis revealed that they are heteropolysaccharides, with AXA-1 showing stronger inhibitory effects on enzyme activities compared to WXA-1.
Article
Food Science & Technology
Yanglin Ji, Dong Liu, Yan Jin, Juan Zhao, Jiang Zhao, Heyu Li, Liwei Li, Hua Zhang, Hao Wang
Summary: The study found that bilberry extract had inhibitory activity against alpha-glucosidase and alpha-amylase, acting as a mixed-type inhibitor and changing the enzyme structure and stability. In vivo study also showed a hypoglycaemic effect of bilberry extract. Molecular docking assay indicated that bilberry extract could be a potential glycosidase inhibitor.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Weidan Guo, Yu Xiao, Xiangjin Fu, Zhao Long, Yue Wu, Qinlu Lin, Kangzi Ren, Liwen Jiang
Summary: In this study, the effect of Douchi extract (DWE) on a-glucosidase and angiotensin-converting enzymes (ACE) was investigated. Peptidomics approach based on UPLC-MS/MS was used to identify several novel peptides with inhibitory activity against a-glucosidase and ACE. The results showed that DWE had high inhibition rates on a-glucosidase and moderate inhibition rates on ACE. Through peptidomics and molecular docking, new peptides with potential inhibitory activity against a-glucosidase and ACE were discovered.
Article
Food Science & Technology
S. A. N. A. GAMMOH, M. U. H. A. M. M. A. D. H. ALU'DATT, M. O. H. A. M. M. A. D. N. ALHAMAD, M. O. H. A. M. M. A. D. ALROSAN, B. E. L. A. L. AL-HUSEIN, DOA'A G. AL-U'DATT, S. H. A. R. I. F. A. AL-KANDARI, T. A. H. A. RABABAH, Z. A. I. D. AMMARI, B. O. R. H. A. N. A. ALBISS, H. A. Y. A. ALZOUBI, S. T. A. N. KUBOW
Summary: This study investigates the biological properties of bioactive peptides derived from digestive enzymatic hydrolysis for nanoscaled protein particles from camel whey proteins. The findings demonstrate that enzymatic hydrolysis and/or ultrasonication of camel whey proteins can enhance their antioxidant, anti-hypertensive, and anti-diabetic properties.
INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY
(2022)
Article
Plant Sciences
Ha-Rim Kim, Paulrayer Antonisamy, Ye-Seul Kim, Guemsan Lee, Hyang-Do Ham, Kang-Beom Kwon
Summary: The study indicates that the plant extract of Amomum villosum Lomb or Indian cardamom dried fruits has significant inhibitory effects on the activity of alpha-glucosidase, making it a potential natural treatment option for type-2 diabetes with fewer side effects than acarbose.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2022)
Article
Food Science & Technology
Maria Sapatinha, Claudia M. Afonso, Carlos L. Cardoso, Carla Pires, Rogerio Mendes, Maria P. Montero, Maria C. Gomez-Guillen, Narcisa M. Bandarra
Summary: To develop a healthy and easily absorbable food for the elderly, a functional ready-to-eat seafood based on restructured fish fillets and encapsulated fish oil was prepared. The study analyzed the lipid fraction and bioaccessibility of the product. The results showed that frying increased the n6 PUFA content and bioaccessibility varied among different fish products.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Ana L. Alves, Ana C. Carvalho, Ines Machado, Gabriela S. Diogo, Emanuel M. Fernandes, Vania I. B. Castro, Ricardo A. Pires, Jose A. Vazquez, Ricardo I. Perez-Martin, Miguel Alaminos, Rui L. Reis, Tiago H. Silva
Summary: This study evaluated the potential of Gelatin Methacryloyl (GelMA) hydrogels produced from marine-derived gelatin for corneal stromal applications. The hydrogels exhibited excellent optical and swelling properties, easy handling, structural stability, and adequate degradation rates. The addition of ascorbic acid enhanced the biological performance of the cells and induced collagen production.
BIOENGINEERING-BASEL
(2023)
Article
Chemistry, Applied
Carolina Camacho, Tatiana Correia, Barbara Teixeira, Rogerio Mendes, Luisa M. P. Valente, M. Fernanda Pessoa, M. Leonor Nunes, Amparo Goncalves
Summary: This study aims to report the chemical changes in sea urchin during refrigerated storage and their contribution to taste. The results showed that adenylate energy charge is a suitable indicator of freshness, while amino acids are related to taste and maturation stage. Storage had minimal effect on amino acids, but nucleotides showed potential changes after day 5.
Article
Food Science & Technology
Jose Antonio Vazquez, Jesus Valcarcel, Maria Sapatinha, Narcisa M. Bandarra, Rogerio Mendes, Carla Pires
Summary: Currently, valorization of fish discards by-products is becoming fundamental for the sustainable management of fisheries and seafood transforming industries. In this study, the production and chemical properties of fish protein hydrolysates (FPH) and oils from gurnard by-products were investigated. The results showed that FPH and oil from gurnard residues had excellent properties in terms of productivity, composition, and nutrition, indicating their valuable interest as potential food and nutraceutical ingredients.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Silvia Blanco, Maria Sapatinha, Mick Mackey, Julie Maguire, Simona Paolacci, Susana Goncalves, Helena Maria Lourenco, Rogerio Mendes, Narcisa Maria Bandarra, Carla Pires
Summary: This study aimed to determine the optimal growing season and harvest time for Alaria esculenta to maximize biomass production and quality. Results showed that the biomass production was significantly higher for seaweed deployed in October. The seaweed had a high content of useful bio compounds with antioxidant and anti-hypertensive activities.
Article
Food Science & Technology
Barbara Teixeira, Helena Vieira, Sandra Martins, Rogerio Mendes
Summary: Consumer expectations of octopus quality are often not met due to excessive weight loss after cooking. A rapid and non-destructive method using time domain reflectometry (TDR) was developed to control water addition. Results showed that immersion in freshwater increased the weight and cooking losses of octopus, potentially misleading consumers.
Article
Chemistry, Applied
Maria Lopez-Pedrouso, Jose M. Lorenzo, Ricard Bou, Jose Antonio Vazquez, Jesus Valcarcel, Monica Toldra, Daniel Franco
Summary: Porcine liver can be used for extracting zinc-protoporphyrin (ZnPP) as a natural red meat pigment. In this study, porcine liver homogenates were incubated at pH 4.8 and 45 degrees C under anaerobic conditions to obtain insoluble ZnPP. The molecular weight distributions of the porcine liver fractions at pH 4.8 and pH 7.5 were similar, but the fractions obtained at pH 4.8 had higher abundance of eight essential amino acids. The results demonstrate the potential of porcine liver in extracting natural pigments and bioactive peptides.
Article
Biochemistry & Molecular Biology
Maria Blanco, Ana C. Sanchez, Begona Correa, Jose Antonio Vazquez, Andrea Vazquez, Ricardo I. Perez-Martin, Carmen G. Sotelo
Summary: Hydrolyzed collagen, glycogen, and hyaluronic acid obtained from underutilized marine bioresources have been successfully used in cosmetic formulations. This study demonstrates the potential use of specific combinations of hydrolyzed collagen and hyaluronic acid as stimulators of collagen synthesis in fibroblast cultures. The ingredients and cosmetic preparation were found to be non-irritant for the skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Green & Sustainable Science & Technology
Jose Antonio Vazquez, Araceli Menduina, Ana I. Duran, Margarita Nogueira, Javier Fraguas, Adrian Pedreira, Jesus Valcarcel
Summary: Marine gelatin is a fascinating biocompound that can be recovered from fish skin by-products. The initial processes for gelatin isolation involve alkaline and acid washing of the skins. Efficient management and purification of these high-protein streams are necessary to prevent environmental pollution and make gelatin recovery viable.
JOURNAL OF CLEANER PRODUCTION
(2023)