Pleiotropy data resource as a primer for investigating co-morbidities/multi-morbidities and their role in disease

Human and mouse essentiality screens as a resource for disease gene discovery

(2020) Pilar Cacheiro et al.   Nature Communications

Phenome-wide functional dissection of pleiotropic effects highlights key molecular pathways for human complex traits

(2020) Anton E. Shikov et al.   Scientific Reports

Adaptation via pleiotropy and linkage: Association mapping reveals a complex genetic architecture within the stickleback Eda locus

(2020) Sophie L. Archambeault et al.   Evolution Letters

Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping

(2020) Kerry A. Geiler-Samerotte et al.   PLOS BIOLOGY

The Human Phenotype Ontology in 2021

(2020) Sebastian Köhler et al.   NUCLEIC ACIDS RESEARCH

Transforming the study of organisms: Phenomic data models and knowledge bases

(2020) Anne E. Thessen et al.   PLoS Computational Biology

Beyond the One Gene–One Disease Paradigm

(2019) Marina Cerrone et al.   CIRCULATION

The dark genome and pleiotropy: challenges for precision medicine

(2019) Steve D. M. Brown et al.   MAMMALIAN GENOME

The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation

(2018) Violeta Muñoz-Fuentes et al.   CONSERVATION GENETICS

Unexplored therapeutic opportunities in the human genome

(2018) Tudor I. Oprea et al.   NATURE REVIEWS DRUG DISCOVERY

High-throughput mouse phenomics for characterizing mammalian gene function

(2018) Steve D. M. Brown et al.   NATURE REVIEWS GENETICS

Large-scale investigation of the reasons why potentially important genes are ignored

(2018) Thomas Stoeger et al.   PLOS BIOLOGY

Mouse Genome Database (MGD) 2019

(2018) Carol J Bult et al.   NUCLEIC ACIDS RESEARCH

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium

(2017) Terrence F Meehan et al.   NATURE GENETICS

Trait Correlations in the Genomics Era

(2017) Julia B. Saltz et al.   TRENDS IN ECOLOGY & EVOLUTION

High-throughput discovery of novel developmental phenotypes

(2016) Mary E. Dickinson et al.   NATURE

The Monarch Initiative: an integrative data and analytic platform connecting phenotypes to genotypes across species

(2016) Christopher J. Mungall et al.   NUCLEIC ACIDS RESEARCH

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

(2015) Martin Hrabě de Angelis et al.   NATURE GENETICS

Finding Our Way through Phenotypes

(2015) Andrew R. Deans et al.   PLOS BIOLOGY

Expanding the mammalian phenotype ontology to support automated exchange of high throughput mouse phenotyping data generated by large-scale mouse knockout screens

(2015) Cynthia L Smith et al.   Journal of Biomedical Semantics

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

(2013) Jacqueline K. White et al.   CELL

PhenoDigm: analyzing curated annotations to associate animal models with human diseases

(2013) D. Smedley et al.   Database-The Journal of Biological Databases and Curation

The many faces of pleiotropy

(2012) Annalise B. Paaby et al.   TRENDS IN GENETICS

Too many roads not taken

(2011) Aled M. Edwards et al.   NATURE

The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms

(2011) Günter P. Wagner et al.   NATURE REVIEWS GENETICS

One Hundred Years of Pleiotropy: A Retrospective

(2010) F. W. Stearns   GENETICS

Genomic patterns of pleiotropy and the evolution of complexity

(2010) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Human Phenotype Ontology: A Tool for Annotating and Analyzing Human Hereditary Disease

(2008) Peter N. Robinson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Pleiotropic scaling of gene effects and the ‘cost of complexity’

(2008) Günter P. Wagner et al.   NATURE