Article
Multidisciplinary Sciences
Jacqueline Langedijk, Ruth Bolier, Dagmar Tolenaars, Lysbeth ten Bloemendaal, Suzanne Duijst, Dirk de Waart, Ulrich Beuers, Piter Bosma, Ronald Oude Elferink
Summary: In this study, researchers found that scratch activity decreased rather than increased in cholestatic mice and wild type mice under cholestasis conditions, indicating that increased plasma ATX activity does not necessarily lead to exacerbated scratching behavior. This raises doubts about the suitability of mice for studying cholestatic itch perception.
SCIENTIFIC REPORTS
(2021)
Review
Dermatology
P. Najafi, O. Dufor, D. Ben Salem, L. Misery, J. -L. Carre
Summary: Researchers are studying the central mechanisms of itch using various experimental methods, including histamine-induced and induction by other chemicals. Some studies suggest that the itch-processing network in the brain could be disrupted in certain diseases.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Dermatology
J. Theunis, C. Nordon, B. Falissard, M. Orri, V. Mengeaud, L. Misery
Summary: The study developed a conceptual framework for a self-reported HRQoL questionnaire for patients with Chronic Pruritus, and tested a 50-item questionnaire with 21 participants, resulting in a 39-item version. Through a cross-sectional study with 251 participants, a 20-item version with three main dimensions was identified, and a two-dimension solution was determined for the questionnaire's factorial structure, making it useful for trials and practitioners.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Allergy
Papapit Tuchinda, Kanokvalai Kulthanan, Leena Chularojanamontri, Chuda Rujitharanawong, Chanika Subchookul, Suphattra Trakanwittayarak
Summary: This study evaluated the validity, reliability, and sensitivity to change of the Thai 5-D itch scale in Thai patients. The results showed strong correlations with related measures, good reliability, and sensitivity to change. Therefore, the Thai 5-D itch scale can be used as a tool to assess pruritus in Thai patients and can also be used in other languages.
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
(2022)
Editorial Material
Dermatology
Shwetapadma Sahu, Gil Yosipovitch
Summary: Nonmelanoma skin cancer is the most common type of cancer in the United States, with pain and pruritus being common presenting clinical manifestations. Studies have shown that patients with squamous cell carcinoma report more pain compared to those with basal cell carcinoma.
CLINICS IN DERMATOLOGY
(2021)
Article
Nutrition & Dietetics
Yong Zhu, John E. Blundell, Norton M. Holschuh, Ross McLean, Ravi S. Menon
Summary: There is currently no validated digital tool available for measuring appetite using a visual analog scale (VAS) on participants' smart phones in virtual settings. In order to address this gap, a digital VAS was developed and a digital cross-over clinical trial was conducted comparing appetite responses measured by this digital tool to a paper-based VAS. The results showed no significant difference in hunger, fullness, satiety, or desire to eat between the digital and paper VAS. The digital VAS is therefore a validated tool for measuring appetite in the real world, providing researchers with a new way to collect appetite data in digital trials using participants' mobile devices.
Article
Psychiatry
Christina D. Sirianni, Christopher A. Abeare, Sami Ali, Parveen Razvi, Arianna Kennedy, Sadie R. Pyne, Laszlo A. Erdodi
Summary: This study aimed to cross-validate the V-5 psychiatric screener across different administration formats and examinee acculturation levels. The V-5 showed high test-retest reliability on Depression and Pain scales, and was sensitive to changes in symptom severity. Classification accuracy was driven by the base rate of the target construct, and was consistent regardless of administration format or English proficiency level. The V-5 demonstrated potential as a cross-culturally robust screening tool sensitive to changes over time, suitable for online administration, and applicable to examinees with limited English proficiency.
PSYCHIATRY RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Juan Trivella, Cynthia Levy
Summary: Pruritus is a disabling symptom in cholestatic liver disease, with lysophosphatidic acid (LPA) and autotaxin (ATX) correlating with symptom intensity. Conventional therapies are effective for some patients, but experimental treatments may be necessary for refractory cases. Ongoing research aims to explore new drugs targeting the ATX-LPA axis for a more effective management of cholestatic itching.
EXPERT OPINION ON DRUG SAFETY
(2021)
Article
Otorhinolaryngology
Ana Margarida Amorim, Joao Simoes, Joana Goncalves, Mafalda Ferreira, Joao Carlos Ribeiro
Summary: This study translated and cross-culturally adapted the Visual Vertigo Analogue Scale (VVAS) from English to Portuguese, and validated its use for assessing self-perceived and severity of visual vertigo in Portuguese patients with vestibular disorders.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Article
Engineering, Multidisciplinary
Disai Yang, Haiping Ai, Jiantao Liu, Bingwei He
Summary: This paper solves the scale ambiguity in underwater monocular visual odometry by using 2D sonar measurements from three viewpoints. The proposed method allows spatial distribution of observation points, extending its applicability to more general environments. A constraint weighting approach is introduced to reduce the influence of noisy input. Experimental results demonstrate the improved accuracy and lower time consumption of the proposed method.
Article
Medicine, Research & Experimental
Adrian Castillo-Allendes, Daniel Guzman-Ferrada, Eric J. Hunter, Eduardo Fuentes-Lopez
Summary: This study investigated the feasibility of using three visual analog scales (VASs) for voice quality and symptoms as a screening tool in call center agents. The results demonstrated an association between VASs and vocal symptoms and acoustic voice parameters, suggesting that VASs can be used to identify voice complaints in call center workers.
Review
Gastroenterology & Hepatology
Ulrich Beuers, Frank Wolters, Ronald P. J. Oude Elferink
Summary: Pruritus in cholestatic liver diseases is a common symptom that significantly impairs quality of life. This Review provides an overview of the mechanisms underlying cholestasis-associated itch, discusses potential pruritogens, and highlights therapeutic approaches for managing pruritus in different conditions.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Robotics
Yassine Ahmine, Guillaume Caron, Fatima Chouireb, El Mustapha Mouaddib
Summary: The algorithm proposed in the letter improves the robustness of image alignment by optimizing scale parameters and camera pose parameters, adapting to scale changes at different levels. Experiments show that the algorithm outperforms the current state-of-the-art fixed scale pyramid alignment method on the TUM RGB-D dataset.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2021)
Article
Rheumatology
Weiyu Ye, Simon Hackett, Claire Vandevelde, Sarah Twigg, Philip S. Helliwell, Laura C. Coates
Summary: In patients with PsA, there is reasonable agreement between the VAS and NRS in evaluating key patient-reported outcomes. Results from both scales are correlated with disease severity and life impact.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Dermatology
S. Staender, C. Zeidler, M. Pereira, J. C. Szepietowski, L. McLeod, S. Qin, N. Williams, T. Sciascia, M. Augustin
Summary: This study evaluated the safety and efficacy of nalbuphine ER for prurigo nodularis and assessed the psychometric properties of the Worst Itch Numeric Rating Scale (WI-NRS). The results showed that WI-NRS has good measurement properties and can be used to evaluate treatment change in PN.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Gastroenterology & Hepatology
Cynthia Levy, Stuart Kendrick, Christopher L. Bowlus, Atsushi Tanaka, David Jones, Andreas E. Kremer, Marlyn J. Mayo, Nazneen Haque, Robyn von Maltzahn, Matthew Allinder, Brandon Swift, Megan M. McLaughlin, Gideon M. Hirschfield, GLIMMER Study Grp
Summary: GLIMMER evaluated the dose-response, efficacy, and safety of linerixibat in the treatment of cholestatic pruritus associated with primary biliary cholangitis (PBC). The study found that linerixibat did not show significant difference in itch reduction compared to placebo in the primary intent-to-treat analysis, but it demonstrated a significant dose-dependent reduction in itch in the per protocol population. A well-tolerated dose was identified for Phase 3 investigation in the treatment of cholestatic pruritus in PBC.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Christopher L. Bowlus, Lionel Arrive, Annika Bergquist, Mark Deneau, Lisa Forman, Sumera I. Ilyas, Keri E. Lunsford, Mercedes Martinez, Gonzalo Sapisochin, Rachna Shroff, James H. Tabibian, David N. Assis
Letter
Gastroenterology & Hepatology
Lisa M. M. Forman, Gonzalo Sapisochin, David N. N. Assis, Lionel Arrive, Annika Bergquist, Christopher L. L. Bowlus, Mark Deneau, Sumera I. I. Ilyas, Keri E. E. Lunsford, Mercedes Martinez, Rachna Shroff, James H. H. Tabibian
Article
Gastroenterology & Hepatology
Michael Trauner, Chuhan Chung, Kate Sterling, Xiangyu Liu, Xiaomin Lu, Jun Xu, Clare Tempany-Afdhal, Zachary D. Goodman, Martti Faerkkilae, Atsushi Tanaka, Palak Trivedi, Kris V. Kowdley, Christopher L. Bowlus, Cynthia Levy, Robert P. Myers
Summary: This article presents the background of PSC and the design and implementation of the phase 3 PRIMIS trial, which aims to evaluate the efficacy and safety of cilofexor in noncirrhotic patients with large-duct PSC. The primary objective is to assess whether cilofexor reduces the risk of fibrosis progression compared with placebo.
BMC GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Gideon M. Hirschfield, Mitchell L. Shiffman, Aliya Gulamhusein, Kris Kowdley, John M. Vierling, Cynthia Levy, Andreas E. Kremer, Ehud Zigmond, Pietro Andreone, Stuart C. Gordon, Christopher L. Bowlus, Eric J. Lawitz, Richard J. Aspinall, Daniel S. Pratt, Karina Raikhelson, Maria S. Gonzalez-Huezo, Michael A. Heneghan, Sook-Hyang Jeong, Alma L. Ladron de Guevara, Marlyn J. Mayo, George N. Dalekos, Joost P. H. Drenth, Ewa Janczewska, Barbara A. Leggett, Frederik Nevens, Victor Vargas, Eli Zuckerman, Christophe Corpechot, Eduardo Fassio, Holger Hinrichsen, Pietro Invernizzi, Palak J. Trivedi, Lisa Forman, David E. J. Jones, Stephen D. Ryder, Mark G. Swain, Alexandra Steinberg, Pol F. Boudes, Yun-Jung Choi, Charles A. McWherter
Summary: This study evaluated the efficacy and safety of seladelpar in patients with primary biliary cholangitis who had inadequate response or intolerance to ursodeoxycholic acid. The results showed that seladelpar significantly improved liver biochemistry and pruritus in these patients, and it was well tolerated.
Article
Gastroenterology & Hepatology
Pietro Invernizzi, Marco Carbone, David Jones, Cynthia Levy, Nicola Little, Philippe Wiesel, Frederik Nevens, study invest
Summary: This study investigated the efficacy and safety of setanaxib, a NOX1/4 inhibitor, in patients with PBC. The results showed that setanaxib can improve fatigue and certain biochemical markers. However, the primary endpoint was not met. These findings provide preliminary evidence for the further evaluation of setanaxib in future clinical trials.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Cynthia Levy, Michael Manns, Gideon Hirschfield
Summary: Primary biliary cholangitis is an autoimmune disease with symptoms including fatigue, itch, abdominal pain, and sicca complex. Treatment focuses on cholestatic consequences.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Correction
Gastroenterology & Hepatology
Marlyn Mayo, Elizabeth T. Carey, Helen R. Smith, Andrea Mospan, Megan McLaughlin, April L. Thompson, Heather Morris, Robert Sandefur, W. Ray Kim, Christopher Bowlus, TARGET PBC Investigators, Cynthia Levy
DIGESTIVE DISEASES AND SCIENCES
(2023)
Editorial Material
Gastroenterology & Hepatology
Christopher L. Bowlus, Cynthia Levy
Article
Oncology
Al B. Benson, Michael I. D'Angelica, Thomas Abrams, Daniel E. Abbott, Aijaz Ahmed, Daniel A. Anaya, Robert Anders, Chandrakanth Are, Melinda Bachini, David Binder, Mitesh Borad, Christopher Bowlus, Daniel Brown, Adam Burgoyne, Jason Castellanos, Prabhleen Chahal, Jordan Cloyd, Anne M. Covey, Evan S. Glazer, William G. Hawkins, Renuka Iyer, Rojymon Jacob, Lawrence Jennings, R. Kate Kelley, Robin Kim, Matthew Levine, Manisha Palta, James O. Park, Steven Raman, Sanjay Reddy, Sean Ronnekleiv-Kelly, Vaibhav Sahai, Gagandeep Singh, Stacey Stein, Anita Turk, Jean-Nicolas Vauthey, Alan P. Venook, Adam Yopp, Nicole McMillian, Ryan Schonfeld, Cindy Hochstetler
Summary: In 2023, the NCCN Guidelines for Hepatobiliary Cancers were divided into two separate guidelines: Hepatocellular Carcinoma and Biliary Tract Cancers. The Biliary Tract Cancers guidelines provide recommendations for the evaluation and comprehensive care of patients with gallbladder cancer, intrahepatic cholangiocarcinoma, and extrahepatic cholangiocarcinoma. A multidisciplinary panel of experts meets regularly to review new data and therapies.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Article
Medicine, General & Internal
Elnaz Payani, Dionysios Koliogiannis, Markus Bo Schoenberg, Dominik Koch, Daniela Eser-Valeri, Gerald Denk, Markus Rehm, Simon Schaefer, Ursula Ehmer, Andreas E. Kremer, Bruno Meiser, Jens Werner, Markus Guba, Nikolaus Boerner
Summary: This observational study examines the characteristics and survival of patients who are removed from the liver transplant waiting list. The findings indicate that assessing post-delisting survival and closely monitoring delisted patients are crucial for improving the survival rate of liver failure patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Kris. V. V. Kowdley, Christopher. L. L. Bowlus, Cynthia Levy, Marlyn. J. J. Mayo, Daniel. S. S. Pratt, Raj Vuppalanchi, Zobair. M. M. Younossi
Summary: Primary biliary cholangitis (PBC) is a chronic, cholestatic, autoimmune liver disease. There have been recent important developments in the diagnosis, treatment, and monitoring of patients with PBC. In this updated expert consensus document, we provide updates on staging, noninvasive prognostic tools, and a treatment algorithm for clinicians managing PBC.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)