Review
Biochemistry & Molecular Biology
Hayden W. Hyatt, Scott K. Powers
Summary: Skeletal muscle, essential for functions like breathing and movement, is susceptible to wasting due to various factors such as chronic diseases, cancer treatment, aging, and inactivity. Mitochondrial dysfunction plays a key role in this muscle wasting process, linking it to conditions like cancer, sepsis, and aging. Future research directions in this field are crucial for understanding and addressing muscle wasting.
Review
Biochemistry & Molecular Biology
Arman Fesharaki-Zadeh
Summary: Traumatic Brain Injury (TBI) is a major cause of disability worldwide. The complex neurometabolic cascade, including oxidative stress, plays a key role in TBI. Antioxidant therapies offer a promising treatment option for TBI, leading to cognitive and functional recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Peiman Zandi, Ewald Schnug
Summary: Environmental changes caused by anthropogenic activities have a significant impact on plants, leading to the generation of reactive oxygen species (ROS) and ultimately oxidative stress. Plants have developed defensive mechanisms, including enzymatic and non-enzymatic antioxidants, to scavenge excess ROS and maintain cellular redox homeostasis. Additionally, plant-microbe interactions have been found to improve immune systems in plants under stress. Understanding and studying these antioxidant systems and beneficial microbiome interactions in plants are important for plant survival and productivity.
Article
Plant Sciences
Pavel Kerchev, Frank Van Breusegem
Summary: Reactive oxygen species (ROS), once considered harmful metabolic byproducts, are now seen as integral to cellular programs, activating signaling pathways that regulate plant growth, development, and defense. Adverse environmental conditions can lead to excessive ROS levels, causing oxidative stress and negative impacts on cellular components. Research efforts have focused on enhancing antioxidant mechanisms to improve oxidative stress resilience in both model and crop species.
Article
Plant Sciences
Tushar Khare, Dhanashree Dange, Ashwini Jadhav, Varsha Shriram, Suresh Gosavi, Vinay Kumar
Summary: The study revealed that nano-sized aluminum oxyhydroxide particles had negative impacts on V. radiata plants, reducing biomass production, damaging cellular membrane stability, and increasing chlorophyll content. Exposure to 12 mM nBhm resulted in oxidative and nitrosative bursts, as well as activation of antioxidative machinery and non-enzymatic antioxidants. The findings suggest a dose-dependent toxicity of nBhm on V. radiata, with higher concentrations above or equal to 8 mM showing greater negative effects.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Review
Biochemistry & Molecular Biology
Masuko Ushio-Fukai, Dipankar Ash, Sheela Nagarkoti, Eric J. Belin de Chantemele, David J. R. Fulton, Tohru Fukai
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles as signaling molecules at physiological levels, but excess levels are associated with cardiovascular disease. Cells regulate ROS and RNS levels by controlling metabolic pathways, with implications for disease treatment strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Sulagna Dutta, Pallav Sengupta, Sanghamitra Das, Petr Slama, Shubhadeep Roychoudhury
Summary: Reactive nitrogen species (RNS) play important roles in male reproduction, but excessive levels can impair fertility by affecting testicular functions and compromising semen quality. High RNS levels lead to abnormalities in germ cells and gametes, and severely impact maturation and fertilization processes. Conventional semen analyses are not reliable predictors for assisted reproductive technology outcomes in cases of male infertility, highlighting the need for novel assessment and treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria Robles, Rafael Torronteras, Carol Ostojic, Cinta Oria, Maria Cuaresma, Ines Garbayo, Francisco Navarro, Carlos Vilchez
Summary: This study investigated the physiological and biochemical responses of Coccomyxa onubensis to Fe(III)-induced stress. The results showed that moderate levels of Fe(III) improved the growth and photosynthetic viability of C. onubensis, as well as triggered antioxidant responses. The findings suggest that C. onubensis has a notable antioxidant capacity, making it suitable for producing cell extracts with potential anti-inflammatory activity.
Review
Biochemistry & Molecular Biology
Zhen Zeng, Christoph Centner, Albert Gollhofer, Daniel Koenig
Summary: Whole dietary strategies rich in antioxidants have gained attention for their potential to alleviate exercise-induced oxidative stress, with most studies showing favorable effects. However, research on the effects of such strategies on oxidative stress is still limited, and further systematically designed studies are needed to strengthen the evidence.
Review
Biochemistry & Molecular Biology
Maochao Luo, Li Zhou, Zhao Huang, Bowen Li, Edouard C. Nice, Jia Xu, Canhua Huang
Summary: Cancer is associated with oxidative stress, and targeting this imbalance between reactive oxygen species (ROS) and antioxidants may have therapeutic potential. However, the clinical efficacy of antioxidants in cancer treatment remains uncertain. This review discusses the rationale and recent advances in antioxidant therapy for cancer, as well as potential strategies for improving its effectiveness.
Review
Biochemistry & Molecular Biology
Elena-Codruta Dobrica, Matei-Alexandru Cozma, Mihnea-Alexandru Gaman, Vlad-Mihai Voiculescu, Amelia Maria Gaman
Summary: Psoriasis is associated with oxidative stress, and the duration and severity of the disease are positively correlated with the concentration of oxidative stress markers. The crosstalk between psoriasis and oxidative stress is influenced by polymorphisms in genes related to redox balance. Further research should focus on evaluating oxidative stress biomarkers and studying the polymorphisms in genes regulating redox balance in psoriasis patients, as well as translating these findings into the management of psoriasis and understanding its pathogenesis.
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Jeyasree M. Ganesh, P. Prerana, Arun Dharmarajan, Sudha Warrier, Rajesh Kumar Gandhirajan
Summary: Oxidation-reduction reactions have played a significant role in the chemical evolution of life forms. Reactive oxygen species (ROS) play an important role in cellular signaling, but high levels of ROS can cause severe damage to tissues. Elevated and chronic levels of ROS are associated with carcinogenesis, and some therapies rely on altering ROS levels to eliminate tumor cells. The effective modulation of ROS levels has been a focal point in recent research.
FREE RADICAL RESEARCH
(2022)
Review
Oncology
Maria Alba Sorolla, Ivan Hidalgo, Anabel Sorolla, Robert Montal, Ona Pallise, Antonieta Salud, Eva Parisi
Summary: Colorectal cancer is associated with a high mortality rate, and oxidative stress has been linked to its initiation and progression. ROS play diverse roles in cancer, and ROS-modulating agents may have therapeutic potential for cancer patients.
Review
Toxicology
Xiaoqing Xu, Xiaohui Wang, Yaqin Yang, Irma Ares, Marta Martinez, Bernardo Lopez-Torres, Maria-Rosa Martinez-Larranaga, Xu Wang, Arturo Anadon, Maria-Aranzazu Martinez
Summary: This article reviews the effects of neonicotinoids on mitochondria and evaluates the protective effects of various active substances against neonicotinoid-induced toxicity. The research found that neonicotinoids can disrupt mitochondrial calcium ions homeostasis, inhibit mitochondrial respiration, and induce reactive oxygen species production, which leads to damage in non-target organisms. However, several active substances can protect against neonicotinoid-induced systemic toxicity by inhibiting oxidative signaling pathways, apoptosis, and lipid peroxidation. The article emphasizes the importance and urgency of developing neonicotinoid antidotes, with a focus on targeted mitochondrial antidotes.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Physiology
Philip D. Coblentz, Bumsoo Ahn, Linda F. Hayward, Jeung-Ki Yoo, Demetra D. Christou, Leonardo F. Ferreira
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2019)
Article
Sport Sciences
Andres Mor Huertas, Aaron B. Morton, J. Matthew Hinkey, Noriko Ichinoseki-Sekine, Ashley J. Smuder
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2020)
Article
Cell Biology
Shylesh Bhaskaran, Natalie Pollock, Peter C. Macpherson, Bumsoo Ahn, Katarzyna M. Piekarz, Caroline A. Staunton, Jacob L. Brown, Rizwan Qaisar, Aphrodite Vasilaki, Arlan Richardson, Anne McArdle, Malcolm J. Jackson, Susan V. Brooks, Holly Van Remmen
Article
Biochemistry & Molecular Biology
Ashley J. Smuder, Sara M. Turner, Cassandra M. Schuster, Aaron B. Morton, J. Matthew Hinkley, David D. Fuller
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Geriatrics & Gerontology
Jacob L. Brown, Marcus M. Lawrence, Bumsoo Ahn, Parker Kneis, Katarzyna M. Piekarz, Rizwan Qaisar, Rojina Ranjit, Jan Bian, Gavin Pharaoh, Chase Brown, Fredrick F. Peelor, Michael T. Kinter, Benjamin F. Miller, Arlan Richardson, Holly Van Remmen
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2020)
Article
Medicine, Research & Experimental
Stephanie E. Hall, Bumsoo Ahn, Ashley J. Smuder, Aaron B. Morton, J. Matthew Hinkley, Michael P. Wiggs, Kurt J. Sollanek, Hayden Hyatt, Scott K. Powers
Summary: Mechanical ventilation is a life-saving intervention, but can lead to inspiratory muscle weakness over time. Research suggests blocking angiotensin II type 1 receptors may protect against this weakness. Comparing two ARBs, irbesartan and olmesartan, it was found that olmesartan is more effective in protecting against VIDD, providing a potential future therapy.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Rizwan Qaisar, Gavin Pharaoh, Shylesh Bhaskaran, Hongyang Xu, Rojina Ranjit, Jan Bian, Bumsoo Ahn, Constantin Georgescu, Jonathan D. Wren, Holly Van Remmen
Summary: The study showed that pharmacological activation of SERCA can mitigate sarcopenia phenotype in aging mice, reversing reductions in muscle mass and force generation, and preventing an increase in mitochondrial ROS production. These effects are mediated in part by enhanced cellular energetics through activation of PGC1-alpha, UCP1, HSF1, and APMK, as well as increased regenerative capacity by suppression of MEF2C and p38 MAPK signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yu Su, Bumsoo Ahn, Peter C. D. Macpherson, Rojina Ranjit, Dennis R. Claflin, Holly Van Remmen, Susan Brooks
Summary: Restoring CuZnSOD specifically in neurons of mice deficient in SOD can prevent muscle atrophy and loss of force, and restore mitochondrial function, ROS generation, and calcium handling levels. This suggests that intact neuronal function and innervation are key to maintaining excitation-contraction coupling and muscle mitochondrial function.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Rohan Varshney, Rojina Ranjit, Ying Ann Chiao, Michael Kinter, Bumsoo Ahn
Summary: Mice lacking cytoplasmic superoxide dismutase exhibit an increase in heart weights and concentric hypertrophy, indicating a pathological adaptation of the hearts to oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Aaron B. Morton, Nicole L. Jacobsen, Steven S. Segal
Summary: Dual targeting of blood vessels and nerves to promote neurovascular regeneration is an emerging therapeutic approach in biomedical engineering, with the cross talk between emergent vessels and nerves during regeneration in adults poorly understood. Advances in microfabrication, cell culture techniques, and progenitor cell biology hold great promise for engineering bioconstructs able to restore organ function after volumetric muscle loss.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Noriko Ichinoseki-Sekine, Ashley J. Smuder, Aaron B. Morton, James M. Hinkley, Andres Mor Huertas, Scott K. Powers
Summary: Mechanical ventilation can lead to ventilator-induced diaphragm dysfunction (VIDD), but there is currently no standard treatment available. Research shows that sodium sulfide can protect the diaphragm from MV-induced damage, indicating therapeutic potential for preventing VIDD.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Cell Biology
Bumsoo Ahn, Rojina Ranjit, Parker Kneis, Hongyang Xu, Katarzyna M. Piekarz, Willard M. Freeman, Michael Kinter, Arlan Richardson, Qitao Ran, Susan V. Brooks, Holly Van Remmen
Summary: The study aimed to determine the impact of mitochondrial hydrogen peroxide on muscle aging and contractile dysfunction. Results showed that muscle-specific overexpression of mPRDX3 can reduce mitochondrial H2O2 generation, improve mitochondrial function, and mitigate loss of muscle quantity and quality, despite the persistence of neuromuscular junction impairment.
Article
Multidisciplinary Sciences
Hongyang Xu, Bumsoo Ahn, Holly Van Remmen
Summary: Aging and oxidative stress have specific impacts on mechanisms related to muscle weakness, including reduced membrane excitability, altered signaling and stability, decreased Ca2+ sensitivity, modified SERCA activity, disrupted Ca2+ homeostasis, and impaired mitochondrial function.
Article
Biochemistry & Molecular Biology
Rojina Ranjit, Holly Van Remmen, Bumsoo Ahn
Summary: Sarcopenia, the progressive loss of muscle mass and dysfunction, affects the elderly and has negative effects on their quality of life. However, no pharmacological therapies are currently available for this condition. Recent studies have shown that ghrelin, a gut-released hormone, has protective effects on skeletal muscle. In this study, it was found that unacylated ghrelin can reduce muscle atrophy and contractile dysfunction.
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)