An mTOR anti-sense oligonucleotide decreases polycystic kidney disease in mice with a targeted mutation in Pkd2

Folate-Conjugated Rapamycin Slows Progression of Polycystic Kidney Disease

(2012) J. M. Shillingford et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeting mTOR globally in cancer: Thinking beyond rapamycin

(2011) Boris Shor et al.   CELL CYCLE

mTOR complex 2 signaling and functions

(2011) Won Jun Oh et al.   CELL CYCLE

mTOR signaling in disease

(2011) Eva Dazert et al.   CURRENT OPINION IN CELL BIOLOGY

Neuroprotective, immunosuppressant and antineoplastic properties of mTOR inhibitors: current and emerging therapeutic options

(2011) Giuseppe Pignataro et al.   CURRENT OPINION IN PHARMACOLOGY

Multiple Site Acetylation of Rictor Stimulates Mammalian Target of Rapamycin Complex 2 (mTORC2)-dependent Phosphorylation of Akt Protein

(2011) Emily J. Glidden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling

(2011) V. S. Rodrik-Outmezguine et al.   Cancer Discovery

Perspectives on the role of mTORC2 in B lymphocyte development, immunity and tumorigenesis

(2011) Adam S. Lazorchak et al.   Protein & Cell

Branching morphogenesis: Rac signaling “PIX” tubulogenesis. Focus on “Pak1 regulates branching morphogenesis in 3D MDCK cell culture by a PIX and β1-integrin-dependent mechanism”

(2010) James A. Marrs   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cyclic AMP-mediated cyst expansion

(2010) Darren P. Wallace   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Curcumin inhibits renal cyst formation and enlargement in vitro by regulating intracellular signaling pathways

(2010) Jinsheng Gao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

(2010) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin Ameliorates PKD Resulting from Conditional Inactivation of Pkd1

(2010) J. M. Shillingford et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sirolimus Therapy to Halt the Progression of ADPKD

(2010) N. Perico et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The mTOR Pathway Is Activated in Human Autosomal-Recessive Polycystic Kidney Disease

(2010) Jan Ulrich Becker et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Sirolimus attenuates disease progression in an orthologous mouse model of human autosomal dominant polycystic kidney disease

(2010) Iram Zafar et al.   KIDNEY INTERNATIONAL

Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models

(2010) Thomas A Natoli et al.   NATURE MEDICINE

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct patterns of kidney and liver cyst growth in pkd2(WS25/−) mice

(2010) R. Brian Doctor et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Inhibition of mTOR with sirolimus does not attenuate progression of liver and kidney disease in PCK rats

(2010) C. Renken et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Sirolimus and Kidney Growth in Autosomal Dominant Polycystic Kidney Disease

(2010) Andreas L. Serra et al.   NEW ENGLAND JOURNAL OF MEDICINE

Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease

(2010) Gerd Walz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapamycin inhibits mTORC1, but not completely

(2009) Carson C. Thoreen et al.   Autophagy

mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

(2009) David A. Guertin et al.   CANCER CELL

Long-term rapamycin therapy in the Han:SPRD rat model of polycystic kidney disease (PKD)

(2009) I. Zafar et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Activation of the AKT/mTOR pathway in autosomal recessive polycystic kidney disease (ARPKD)

(2009) D.-C. Fischer et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mammalian Target of Rapamycin and Caspase Inhibitors in Polycystic Kidney Disease

(2008) C. L. Edelstein   Clinical Journal of the American Society of Nephrology

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

The PI 3-kinase and mTOR signaling pathways are important modulators of epithelial tubule formation

(2008) Shereaf Walid et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sirolimus Reduces Polycystic Liver Volume in ADPKD Patients

(2008) Q. Qian et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autosomal Dominant Polycystic Kidney Disease

(2008) Jared J. Grantham   NEW ENGLAND JOURNAL OF MEDICINE