Article
Surgery
Perisa Ruhi-Williams, Baolin Wu, Jeffry Nahmias, Fabio Sagebin, Reza Fazl Alizadeh, Kishore M. Gadde, Alpesh Amin, Ninh T. Nguyen
Summary: This study analyzed the characteristics and outcomes of veno-venous (V-V) extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS) due to COVID-19 versus non-COVID causes. The results showed that patients with COVID-19 ARDS requiring V-V ECMO support had higher in-hospital mortality, longer length of stay, and higher direct hospitalization cost compared to non-COVID etiologies.
Article
Cardiac & Cardiovascular Systems
J. W. Awori Hayanga, Subhasis Chatterjee, Bo Soo Kim, HelenMari Merritt-Genore, Rita Carrie Karianna Milewski, Jonathan W. Haft, Rakesh C. Arora
Summary: The high transmissibility of SARS-CoV-2 and severity of COVID-19 have created a global health emergency. The virus enters host cells through the spike membrane protein, with angiotensin-converting enzyme 2 as the receptor. The pandemic has tested the global health infrastructure and led to the exploration of new strategies. ECMO has been used as a rescue option, but there is no consensus on a specific scoring system for its severity assessment.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Critical Care Medicine
Kollengode Ramanathan, Kiran Shekar, Ryan Ruiyang Ling, Ryan P. Barbaro, Suei Nee Wong, Chuen Seng Tan, Bram Rochwerg, Shannon M. Fernando, Shinhiro Takeda, Graeme MacLaren, Eddy Fan, Daniel Brodie
Summary: A systematic review and meta-analysis of ECMO use in COVID-19 patients with ARDS found venovenous ECMO to be the predominant mode, with age and duration of ECMO support associated with increased mortality. In-hospital mortality for COVID-19 patients receiving ECMO during the first year of the pandemic was 37.1%. Efficacy of venovenous ECMO in selected COVID-19 patients with ARDS was highlighted.
Article
Cardiac & Cardiovascular Systems
Yudai Iwasaki, Takuya Shiga, Naoki Hoshi, Daisuke Irimada, Hidehisa Saito, Daisuke Konno, Koji Saito, Masanori Yamauchi
Summary: One major issue during the COVID-19 pandemic is the shortage of intravenous anesthetics. This case report describes a patient with acute respiratory distress syndrome caused by COVID-19 who was treated with ECMO. Due to difficulties in controlling sedation with intravenous anesthetics, inhaled anesthetics were administered via the gas flow of ECMO. This method could help overcome the shortage of intravenous anesthetics.
Article
Critical Care Medicine
Jad Malas, Qiudong Chen, Tao Shen, Dominic Emerson, Tyler Gunn, Dominick Megna, Pedro Catarino, Michael Nurok, Michael Bowdish, Joanna Chikwe, Susan Cheng, Joseph Ebinger, Abirami Kumaresan
Summary: This study aimed to describe the institutional experience with extremely prolonged venovenous extracorporeal membrane oxygenation (ECMO) support for patients with acute respiratory failure. The study found that most patients in this cohort had adult respiratory distress syndrome (ARDS) secondary to COVID-19. Prolonged ECMO support was successful in weaning patients off and enabling their recovery, with a high rate of survival.
CRITICAL CARE MEDICINE
(2023)
Article
Anesthesiology
Sankalp P. Patel, Brian J. Solomon, Robert D. Pascotto, Stephen E. D'Orazio, Elsy Navas, Robert J. Cubeddu, Gaston A. Cudemus
Summary: The importance of the right ventricle (RV) has been magnified due to the exacerbation of RV failure caused by severe acute respiratory syndrome coronavirus 2 infection. Venovenous extracorporeal membranous oxygenation (VV-ECMO) has become a main treatment for severe COVID-19 acute respiratory distress syndrome, and early implementation of a right ventricular assist device may improve patient outcomes.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Medicine, General & Internal
Jing Hua, Xin Zhang, Na Wang, Linyu Ran, Shengyun Wang, Chiungwei Huang, Wei Gao, Chenchen Qian, Wei Guo, Zhongmin Liu, Qiang Li, Feilong Wang
Summary: ECMO may be an effective treatment for critically ill patients with COVID-19, but careful patient selection and management by a trained team are crucial. More randomized controlled trials with larger sample sizes are needed to evaluate the actual effectiveness of ECMO in patients with COVID-19.
FRONTIERS IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Rocco Edoardo Stio, Andrea Montalto, Mariano Feccia, Alfredo Intorcia, Vitaliano Buffa, Vincenzo Cesario, Giulia Petroni, Francesco De Felice, Francesco Musumeci
Summary: The article discusses a case where a 51-year-old male patient presented with acute heart failure symptoms and reduced LVAD flow, ultimately undergoing successful stent implantation to restore adequate cardiac output. The study highlights the importance of catheter-based approach in extracorporeal membrane oxygenation assistance for treating outflow graft stenosis in acutely unstable patients.
Article
Engineering, Biomedical
Jae Kyeom Sim, Kyeongman Jeon, Gee Young Suh, Suryeun Chung, Yang Hyun Cho
Summary: VV ECMO is effective in supporting patients with respiratory failure, but issues like recirculation and right ventricular failure can arise. OxyRVAD, with its advantages of hemodynamic support and facilitating rehabilitation, can be a better option. Combining VV ECMO with OxyRVAD can overcome these challenges and lead to better outcomes for patients in need of lung transplantation.
Article
Medicine, General & Internal
Marion Wiegele, Daniel Laxar, Eva Schaden, Andreas Baierl, Mathias Maleczek, Paul Knoebl, Martina Hermann, Alexander Hermann, Christian Zauner, Johannes Gratz
Summary: This study retrospectively analyzed the use of subcutaneous enoxaparin for systemic anticoagulation in COVID-19 patients undergoing extracorporeal membrane oxygenation. The results showed that enoxaparin was associated with lower rates of thromboembolic and hemorrhagic events compared to unfractionated heparin. The findings suggest that subcutaneous enoxaparin may be a successful alternative for anticoagulation in these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Rodrigo A. Diaz, Jeronimo Graf, Jose M. Zambrano, Carolina Ruiz, Juan A. Espinoza, Sebastian Bravo, Pablo A. Salazar, Juan C. Bahamondes, Luis B. Castillo, Abraham I. J. Gajardo, Andres Kursbaum, Leonila L. Ferreira, Josefa Valenzuela, Roberto E. Castillo, Rodrigo A. Perez-Araos, Marcela Bravo, Andres F. Aquevedo, Mauricio G. Gonzalez, Rodrigo Pereira, Leandro Ortega, Cesar Santis, Paula A. Fernandez, Vilma Cortes, Rodrigo A. Cornejo
Summary: This study identified the cumulative incidence of ECMO use during the first COVID-19 pandemic wave in Chile and described a nationwide cohort of ECMO-supported COVID-19 patients. The 90-day mortality rate of the Chilean cohort of ECMO-supported patients with COVID-19 was found to be 38.8%, comparable to previous reports.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Medicine, General & Internal
Sua Kim, Hyeri Seok, Beong Ki Kim, Jinwook Hwang, Dae Won Park, Jae Seung Shin, Je Hyeong Kim
Summary: This retrospective study compared the clinical course and outcomes of ARDS patients who received VV ECMO based on the etiology of ARDS. COVID-19 patients exhibited lower organ failure scores and longer duration of VV ECMO support, but no significant differences were found in weaning off rate and mortality rates between COVID-19 and non-COVID-19 patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Nicolas Massart, Christophe Guervilly, Alexandre Mansour, Alizee Porto, Erwan Flecher, Maxime Esvan, Claire Fougerou, Pierre Fillatre, Thibault Duburcq, Guillaume Lebreton, Marylou Para, Francois Stephan, Sami Hraiech, James T. Ross, Matthieu Schmidt, Andre Vincentelli, Nicolas Nesseler
Summary: This study aimed to evaluate the potential survival benefit of prone positioning in venovenous ECMO patients with COVID-19-related ARDS. The study found that prone position on ECMO was associated with lower in-hospital mortality. However, more data are needed to draw definitive conclusions.
CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Darya Rudym, Tai Pham, Craig R. Rackley, Giacomo Grasselli, Michaela Anderson, Matthew R. Baldwin, Jeremy Beitler, Cara Agerstrand, Alexis Serra, Lisle A. Winston, Desiree Bonadonna, Natalie Yip, Logan J. Emerson, Amy Dzierba, Joshua Sonett, Darryl Abrams, Niall D. Ferguson, Matthew Bacchetta, Matthieu Schmidt, Daniel Brodie
Summary: This study investigated the association between obesity and mortality in patients with ARDS receiving ECMO. The results showed that patients with obesity had lower ICU mortality than patients without obesity, supporting the idea that obesity should not be considered a general contraindication to ECMO.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Critical Care Medicine
Ricardo Teijeiro-Paradis, Whitney D. Gannon, Eddy Fan
Summary: This narrative review discusses the various complications that can occur during treatment with venovenous extracorporeal membrane oxygenation (V-V ECMO), including both short-term and long-term complications. Patient selection, timing of initiation, and management decisions greatly influence the presence and severity of these potential harms.
CRITICAL CARE MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Nathan J. Smith, Adhitya Ramamurthi, Lyle D. Joyce, Lucian A. Durham, Takushi Kohmoto, David L. Joyce
Summary: In this study, four patients with ischemic cardiomyopathy and left ventricular dysfunction underwent CABG with perioperative ventricular support using a microaxial tMCS device. All patients survived to device explant without device-related complications, demonstrating that perioperative tMCS may be a viable strategy for preventing postoperative low-output state in high-risk CABG patients with low complication rate and acceptable morbidity. Further investigation is needed to explore the impact of microaxial tMCS devices on perioperative outcomes and expand the indications for such devices.
JOURNAL OF CARDIAC SURGERY
(2021)
Article
Surgery
Nathan J. Smith, Devashis Mukherjee, Yu Wang, Ruta Brazauskas, Ariel A. Nelson, Chandler S. Cortina
Summary: Primary pediatric lung malignancies are rare tumors, with the majority of patients being white and aged 12 years and older. Neuroendocrine and blastoma are the most common histologies, and surgery remains an important treatment modality.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Surgery
John M. LeClaire, Nathan J. Smith, Sonal Chandratre, Lisa Rein, Mohammed A. Kamalia, Takushi Kohmoto, Lyle D. Joyce, David L. Joyce
Summary: Donor-recipient race-matching does not significantly influence patient outcomes in organ transplantation, except for some benefit observed in African American liver transplant recipients.
TRANSPLANT INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Michael T. Cain, David Joyce, Brian D. Lahr, Courtney N. Day, Gurpreet S. Sandhu, Sudhir Kushwaha, Lyle D. Joyce
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Engineering, Biomedical
Adhitya Ramamurthi, Michael T. Cain, Nathan Smith, Angelia Espinal, David L. Joyce, Asim Mohammed, Lyle D. Joyce, Lucian A. Durham
Summary: This study presents a case series of transcarotid placement of mLVADs as an alternative option to traditional support strategies or prohibitive arterial anatomy. However, further research is needed to determine its efficacy.
Article
Engineering, Biomedical
Samuel F. Carlson, Nathan J. Smith, Colton Brown, Lyle D. Joyce, David L. Joyce
Article
Anesthesiology
Nathan J. Smith, Beth A. Nance, Lucian A. Durham, Lindsey A. McAlarnen, Erin A. Bishop, M. Tracy Zundel
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Engineering, Biomedical
Sonal R. Chandratre, Nathan J. Smith, Richard W. Walsh, Tammy L. Kindel, Sakthi K. Sundararajan, David L. Joyce, Asim Mohammed
Summary: This study examined BMI changes in LVAD patients and found that weight changes may impact transplant candidacy, with higher BMI groups potentially benefiting from targeted weight-loss interventions.
Article
Engineering, Biomedical
Nathan J. Smith, Nicholas Collar, Padmaraj Duvvuri, Bryan Miles, Ruizhe Wu, Aniko Szabo, Nunzio Gaglianello, Lyle D. Joyce, David L. Joyce
Summary: Myocardial recovery is rare but achievable in patients with non-ischemic cardiomyopathy who receive destination therapy LVAD. A combination of left ventricular unloading and pharmacologic reverse remodeling can increase the rate of recovery. Revascularization during LVAD implantation is safe and beneficial. LVAD therapy may not be the final destination for these patients.
Article
Anesthesiology
Thomas J. Ebert, Craig E. Cumming, Christopher J. Roberts, Missy F. Anglin, Sweeta Gandhi, Christopher J. Anderson, Thomas A. Stekiel, Ross Gliniecki, Shannon M. Dugan, Mohamed T. Abdelrahim, Victoria B. Klinewski, Katherine Sherman
Summary: Reversal of neuromuscular blockade with sugammadex can cause changes in heart rate, but the relationship between dose and heart rate slowing remains unclear.
ANESTHESIA AND ANALGESIA
(2022)
Article
Engineering, Biomedical
Nathan J. Smith, Sarah Park, M. Tracy Zundel, Huaying Dong, Aniko Szabo, Michael T. Cain, Lucian A. Durham
Summary: This study compared the outcomes of ECMO treatment for COVID-19 at our institution. The results showed that ECMO support is beneficial for COVID-19, but comes with significant morbidity. RVAD/ECMO demonstrated consistent advantages in survival, but with declining efficacy during the pandemic.
Article
Surgery
Richard W. Walsh, Nathan J. Smith, John F. Shepherd, Mia S. Turbati, Bi Qing Teng, Ruta Brazauskas, David L. Joyce, Lyle D. Joyce, Lucian Durham Iii, Peter J. Rossi
Summary: In this study, a novel approach to peripheral mechanical circulatory support was compared with a conventional femoral approach, focusing on the incidence of acute limb ischemia.
Article
Cardiac & Cardiovascular Systems
Michael T. Cain, Michal Schafer, Lexie K. Ross, David D. Ivy, Max B. Mitchell, Brett E. Fenster, Todd M. Bull, Alex J. Barker, Daniel Vargas, Jordan R. H. Hoffman
Summary: This study investigated right ventricular (RV) diastolic dysfunction in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension with chronic lung disease (PH-CLD) using 4D-Flow cardiac MRI (CMR). The results showed that reduced E-vorticity could differentiate PAH and PH-CLD from healthy controls, and E-vorticity was further decreased in PAH patients compared to PH-CLD group. Intracardiac flow analysis using 4D-Flow CMR is a sensitive method to differentiate diastolic dysfunction in patients with different PH etiology and similar Doppler echocardiography profile.
PULMONARY CIRCULATION
(2023)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)