Article
Critical Care Medicine
Darya Rudym, Tai Pham, Craig R. Rackley, Giacomo Grasselli, Michaela Anderson, Matthew R. Baldwin, Jeremy Beitler, Cara Agerstrand, Alexis Serra, Lisle A. Winston, Desiree Bonadonna, Natalie Yip, Logan J. Emerson, Amy Dzierba, Joshua Sonett, Darryl Abrams, Niall D. Ferguson, Matthew Bacchetta, Matthieu Schmidt, Daniel Brodie
Summary: This study investigated the association between obesity and mortality in patients with ARDS receiving ECMO. The results showed that patients with obesity had lower ICU mortality than patients without obesity, supporting the idea that obesity should not be considered a general contraindication to ECMO.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Jad Malas, Qiudong Chen, Tao Shen, Dominic Emerson, Tyler Gunn, Dominick Megna, Pedro Catarino, Michael Nurok, Michael Bowdish, Joanna Chikwe, Susan Cheng, Joseph Ebinger, Abirami Kumaresan
Summary: This study aimed to describe the institutional experience with extremely prolonged venovenous extracorporeal membrane oxygenation (ECMO) support for patients with acute respiratory failure. The study found that most patients in this cohort had adult respiratory distress syndrome (ARDS) secondary to COVID-19. Prolonged ECMO support was successful in weaning patients off and enabling their recovery, with a high rate of survival.
CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Oliver Hunsicker, Lukas Beck, Alexander Krannich, Tobias Finger, Vincent Prinz, Claudia Spies, Steffen Weber-Carstens, Stefan Wolf, Jan Adriaan Graw, Mario Menk
Summary: Intracranial hemorrhage is a serious complication in patients receiving venovenous extracorporeal membrane oxygenation during treatment of the acute respiratory distress syndrome. The study found that early occurrence of intracranial hemorrhage is associated with higher 60-day mortality, and adjusting modifiable risk factors may lower the prevalence of this complication.
CRITICAL CARE MEDICINE
(2021)
Review
Critical Care Medicine
Wynne Hsing Poon, Kollengode Ramanathan, Ryan Ruiyang Ling, Isabelle Xiaorui Yang, Chuen Seng Tan, Matthieu Schmidt, Kiran Shekar
Summary: Prone positioning during VV ECMO treatment for ARDS patients can improve survival rates, but may result in longer ICU stays and ECMO durations.
Article
Multidisciplinary Sciences
Ting-Yu Liao, Sheng-Yuan Ruan, Chien-Heng Lai, Li-Jung Tseng, Li-Ta Keng, You-Yi Chen, Chih-Hsien Wang, Jung-Yien Chien, Huey-Dong Wu, Yih-Sharng Chen, Chong-Jen Yu
Summary: This study aimed to investigate the impact of ventilator settings on patient outcomes in influenza-associated ARDS patients receiving vv-ECMO support. The results showed that a higher respiratory rate was associated with higher mortality. Therefore, adjusting the respiratory rate may improve outcomes in this patient population.
Article
Medicine, General & Internal
Kevin Pilarczyk, Katharina Huenges, Burkhard Bewig, Lorenz Balke, Jochen Cremer, Assad Haneya, Bernd Panholzer
Summary: AKI is a common complication in adult patients receiving ECMO support, with two-thirds of patients experiencing moderate to severe AKI and increased morbidity and long-term mortality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Matthieu Petit, Catalin Fetita, Augustin Gaudemer, Ludovic Treluyer, Guillaume Lebreton, Guillaume Franchineau, Guillaume Hekimian, Juliette Chommeloux, Marc Pineton de Chambrun, Nicolas Brechot, Charles-Edouard Luyt, Alain Combes, Matthieu Schmidt
Summary: This study analyzed the characteristics and outcomes of patients with severe acute respiratory distress syndrome who received prone-positioned extracorporeal membrane oxygenation treatment. The results showed that prone-positioning during extracorporeal membrane oxygenation was safe and effective, and was associated with a higher probability of surviving and being weaned-off ECMO at 90 days. Additionally, quantitative lung CT-scan performed before prone-positioning can help predict the improvement in static compliance after that procedure.
CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Rodrigo A. Diaz, Jeronimo Graf, Jose M. Zambrano, Carolina Ruiz, Juan A. Espinoza, Sebastian Bravo, Pablo A. Salazar, Juan C. Bahamondes, Luis B. Castillo, Abraham I. J. Gajardo, Andres Kursbaum, Leonila L. Ferreira, Josefa Valenzuela, Roberto E. Castillo, Rodrigo A. Perez-Araos, Marcela Bravo, Andres F. Aquevedo, Mauricio G. Gonzalez, Rodrigo Pereira, Leandro Ortega, Cesar Santis, Paula A. Fernandez, Vilma Cortes, Rodrigo A. Cornejo
Summary: This study identified the cumulative incidence of ECMO use during the first COVID-19 pandemic wave in Chile and described a nationwide cohort of ECMO-supported COVID-19 patients. The 90-day mortality rate of the Chilean cohort of ECMO-supported patients with COVID-19 was found to be 38.8%, comparable to previous reports.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Marco Giani, Emanuele Rezoagli, Christophe Guervilly, Jonathan Rilinger, Thibault Duburcq, Matthieu Petit, Laura Textoris, Bruno Garcia, Tobias Wengenmayer, Giacomo Bellani, Giacomo Grasselli, Antonio Pesenti, Alain Combes, Giuseppe Foti, Matthieu Schmidt
Summary: This study assesses the association of the timing of prone positioning (PP) during venovenous extracorporeal membrane oxygenation (V-V ECMO) with the probability of being discharged alive from ICU and improvement of respiratory system compliance. The results show that delayed PP during V-V ECMO is associated with lower ICU discharge probability and less improvement in respiratory system compliance. Early PP is beneficial for ARDS patients on ECMO.
CRITICAL CARE MEDICINE
(2023)
Article
Surgery
Perisa Ruhi-Williams, Baolin Wu, Jeffry Nahmias, Fabio Sagebin, Reza Fazl Alizadeh, Kishore M. Gadde, Alpesh Amin, Ninh T. Nguyen
Summary: This study analyzed the characteristics and outcomes of veno-venous (V-V) extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS) due to COVID-19 versus non-COVID causes. The results showed that patients with COVID-19 ARDS requiring V-V ECMO support had higher in-hospital mortality, longer length of stay, and higher direct hospitalization cost compared to non-COVID etiologies.
Article
Biochemistry & Molecular Biology
Li-Chung Chiu, Li-Pang Chuang, Shaw-Woei Leu, Yu- Lin, Chee-Jen Chang, Hsin-Hsien Li, Feng-Chun Tsai, Chih-Hao Chang, Chen-Yiu Hung, Shih-Wei Lin, Han-Chung Hu, Chung-Chi Huang, Huang-Pin Wu, Kuo-Chin Kao
Summary: For patients with severe ARDS, early initiation of ECMO may increase the likelihood of survival, especially for those with more severe conditions. Research has shown a significantly lower hospital mortality rate among patients treated with ECMO compared to those who did not receive ECMO treatment.
Article
Cardiac & Cardiovascular Systems
J. W. Awori Hayanga, Subhasis Chatterjee, Bo Soo Kim, HelenMari Merritt-Genore, Rita Carrie Karianna Milewski, Jonathan W. Haft, Rakesh C. Arora
Summary: The high transmissibility of SARS-CoV-2 and severity of COVID-19 have created a global health emergency. The virus enters host cells through the spike membrane protein, with angiotensin-converting enzyme 2 as the receptor. The pandemic has tested the global health infrastructure and led to the exploration of new strategies. ECMO has been used as a rescue option, but there is no consensus on a specific scoring system for its severity assessment.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Surgery
Ninh T. Nguyen, Brittany Sullivan, Fabio Sagebin, Samuel F. Hohmann, Alpesh Amin, Jeffry Nahmias
Summary: This study analyzed the outcomes of COVID-19 patients with ARDS managed with ECMO across 155 US academic centers. The in-hospital mortality was high but lower than initial reports, highlighting the need for further research to evaluate which patients may benefit from ECMO therapy.
Article
Biochemistry & Molecular Biology
Li-Chung Chiu, Li-Pang Chuang, Shih-Wei Lin, Yu-Ching Chiou, Hsin-Hsien Li, Yung-Chang Chen, Yu- Lin, Chee-Jen Chang, Feng-Chun Tsai, Ko-Wei Chang, Han-Chung Hu, Chung-Chi Huang, Shaw-Woei Leu, Kuo-Chin Kao
Summary: Conservative fluid management can shorten the duration of mechanical ventilation and time spent in intensive care for ARDS patients, without significant impact on survival. Studies suggest that avoiding fluid overload during the early phase of ECMO treatment in severe ARDS patients can be beneficial.
Article
Critical Care Medicine
Marco Giani, Emanuele Rezoagli, Christophe Guervilly, Jonathan Rilinger, Thibault Duburcq, Matthieu Petit, Laura Textoris, Bruno Garcia, Tobias Wengenmayer, Giacomo Grasselli, Antonio Pesenti, Alain Combes, Giuseppe Foti, Matthieu Schmidt
Summary: This study evaluated the association between prone positioning during extracorporeal support and ICU mortality in patients with severe ARDS using pooled individual patient data analysis of European cohort studies. The findings suggest that the use of prone positioning during ECMO was not significantly associated with reduced ICU mortality in a large population of ARDS patients.