标题
Emerging Modulators of TMEM16A and Their Therapeutic Potential
作者
关键词
-
出版物
JOURNAL OF MEMBRANE BIOLOGY
Volume 254, Issue 4, Pages 353-365
出版商
Springer Science and Business Media LLC
发表日期
2021-07-15
DOI
10.1007/s00232-021-00188-9
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis
- (2020) Henry L Danahay et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Development of a QPatch-Automated Electrophysiology Assay for Identifying TMEM16A Small-Molecule Inhibitors
- (2020) Kathryn A. Henckels et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Arctigenin, a novel TMEM16A inhibitor for lung adenocarcinoma therapy
- (2020) Shuai Guo et al. PHARMACOLOGICAL RESEARCH
- Inhibition of TMEM16A Ca2+-activated Cl− channels by avermectins is essential for their anticancer effects
- (2020) Xuan Zhang et al. PHARMACOLOGICAL RESEARCH
- Activation of TMEM16A by natural product canthaxanthin promotes gastrointestinal contraction
- (2020) Qiushuang Ji et al. FASEB JOURNAL
- Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways
- (2019) Kent Miner et al. Frontiers in Pharmacology
- TMEM16A in Cystic Fibrosis: Activating or Inhibiting?
- (2019) Karl Kunzelmann et al. Frontiers in Pharmacology
- Entering the spotlight: Chitosan oligosaccharides as novel activators of CaCCs/TMEM16A
- (2019) Shuai Guo et al. PHARMACOLOGICAL RESEARCH
- The Molecular Mechanism of Ginsenoside Analogs Activating TMEM16A
- (2019) Shuai Guo et al. BIOPHYSICAL JOURNAL
- Synthesis and biological evaluation of novel Ani9 derivatives as potent and selective ANO1 inhibitors
- (2018) Yohan Seo et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Prediction of Novel Anoctamin1 (ANO1) Inhibitors Using 3D-QSAR Pharmacophore Modeling and Molecular Docking
- (2018) Yoon Lee et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Recent advances in TMEM16A: Structure, function, and disease
- (2018) Qiushuang Ji et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Matrine is a novel inhibitor of the TMEM16A chloride channel with antilung adenocarcinoma effects
- (2018) Shuai Guo et al. JOURNAL OF CELLULAR PHYSIOLOGY
- MicroRNA-381 inhibits the metastasis of gastric cancer by targeting TMEM16A expression
- (2017) Qinghua Cao et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A)
- (2017) Eric C. Truong et al. JOURNAL OF MEDICINAL CHEMISTRY
- Identification of Resveratrol, an Herbal Compound, as an Activator of the Calcium-Activated Chloride Channel, TMEM16A
- (2017) Ran Chai et al. JOURNAL OF MEMBRANE BIOLOGY
- Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM
- (2017) Cristina Paulino et al. NATURE
- Cryo-EM structures of the TMEM16A calcium-activated chloride channel
- (2017) Shangyu Dang et al. NATURE
- Ginsenoside Rb1, a novel activator of the TMEM16A chloride channel, augments the contraction of guinea pig ileum
- (2017) Shuai Guo et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Inhibition of ANO1 by luteolin and its cytotoxicity in human prostate cancer PC-3 cells
- (2017) Yohan Seo et al. PLoS One
- Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1
- (2016) Katarzyna A. Piechowicz et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Revealing the activation pathway for TMEM16A chloride channels from macroscopic currents and kinetic models
- (2016) Juan A. Contreras-Vite et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Cellular functions of TMEM16/anoctamin
- (2016) Uhtaek Oh et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Shikonin Inhibits Intestinal Calcium-Activated Chloride Channels and Prevents Rotaviral Diarrhea
- (2016) Yu Jiang et al. Frontiers in Pharmacology
- Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effect on ANO2
- (2016) Yohan Seo et al. PLoS One
- 9-Phenanthrol inhibits recombinant and arterial myocyte TMEM16A channels
- (2015) Sarah K Burris et al. BRITISH JOURNAL OF PHARMACOLOGY
- Quercetin Inhibits Pacemaker Potentials via Nitric Oxide/cGMP-Dependent Activation and TRPM7/ANO1 Channels in Cultured Interstitial Cells of Cajal from Mouse Small Intestine
- (2015) Huijin Gim et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Overexpression of ANO1/TMEM16A, an arterial Ca2+-activated Cl− channel, contributes to spontaneous hypertension
- (2015) Bingxiang Wang et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Anoctamin-1 Cl− Channels in Nociception: Activation by an N-Aroylaminothiazole and Capsaicin and Inhibition by T16A[inh]-A01
- (2015) Farah Deba et al. Molecular Pain
- Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines
- (2015) Yohan Seo et al. PLoS One
- TMEM16A/ANO1 is differentially expressed in HPV-negative versus HPV-positive head and neck squamous cell carcinoma through promoter methylation
- (2015) Ronak Dixit et al. Scientific Reports
- Cystic fibrosis
- (2015) Felix Ratjen et al. Nature Reviews Disease Primers
- Identification of the Novel TMEM16A Inhibitor Dehydroandrographolide and Its Anticancer Activity on SW620 Cells
- (2015) Yujie Sui et al. PLoS One
- Development and validation of HTS assay for screening the calcium-activated chloride channel modulators in TMEM16A stably expressed CHO cells
- (2014) Jinlong Qi et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- A novel biophysical model on calcium and voltage dual dependent gating of calcium-activated chloride channel
- (2014) Suhua Zhang et al. JOURNAL OF THEORETICAL BIOLOGY
- X-ray structure of a calcium-activated TMEM16 lipid scramblase
- (2014) Janine D. Brunner et al. NATURE
- Characterization of the effects of Cl− channel modulators on TMEM16A and bestrophin-1 Ca2+ activated Cl− channels
- (2014) Yani Liu et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Re: Inhibition of Ca2+-Activated Cl- Channel ANO1/TMEM16A Expression Suppresses Tumor Growth and Invasiveness in Human Prostate Carcinoma
- (2013) Anthony Atala JOURNAL OF UROLOGY
- Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling
- (2013) Adrian Britschgi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh-A01
- (2012) Alison J Davis et al. BRITISH JOURNAL OF PHARMACOLOGY
- Fractionation of a Herbal Antidiarrheal Medicine Reveals Eugenol as an Inhibitor of Ca2+-Activated Cl− Channel TMEM16A
- (2012) Zhen Yao et al. PLoS One
- Enhanced Expression of ANO1 in Head and Neck Squamous Cell Carcinoma Causes Cell Migration and Correlates with Poor Prognosis
- (2012) Christian Ruiz et al. PLoS One
- Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction
- (2011) Wan Namkung et al. FASEB JOURNAL
- Altered Expression of Ano1 Variants in Human Diabetic Gastroparesis
- (2011) Amelia Mazzone et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Crofelemer for the treatment of secretory diarrhea
- (2011) Jessica Cottreau et al. Expert Review of Gastroenterology & Hepatology
- Recent Advances in Ligand-Based Drug Design: Relevance and Utility of the Conformationally Sampled Pharmacophore Approach
- (2010) Chayan Acharya et al. Current Computer-Aided Drug Design
- Inhibition of Ca2+-activated Cl− channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea
- (2010) Wan Namkung et al. FASEB JOURNAL
- TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells
- (2010) Wan Namkung et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl– channels
- (2010) Boyi Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- Crofelemer, an Antisecretory Antidiarrheal Proanthocyanidin Oligomer Extracted from Croton lechleri, Targets Two Distinct Intestinal Chloride Channels
- (2009) L. Tradtrantip et al. MOLECULAR PHARMACOLOGY
- Chloride channels as drug targets
- (2009) Alan S. Verkman et al. NATURE REVIEWS DRUG DISCOVERY
- Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit
- (2008) Björn Christian Schroeder et al. CELL
- TMEM16A confers receptor-activated calcium-dependent chloride conductance
- (2008) Young Duk Yang et al. NATURE
- TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity
- (2008) A. Caputo et al. SCIENCE
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