标题
Molecular biology of the SARs‐CoV‐2 spike protein: A review of current knowledge
作者
关键词
-
出版物
JOURNAL OF MEDICAL VIROLOGY
Volume 93, Issue 10, Pages 5729-5741
出版商
Wiley
发表日期
2021-06-14
DOI
10.1002/jmv.27132
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Human SARS CoV ‐2 spike protein mutations
- (2021) Lalitha Guruprasad PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor
- (2021) Jarrod Shilts et al. Scientific Reports
- Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system
- (2021) Man Lung Yeung et al. CELL
- Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China
- (2020) Aiping Wu et al. Cell Host & Microbe
- Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein
- (2020) Shuai Xia et al. Cellular & Molecular Immunology
- Emerging coronaviruses: Genome structure, replication, and pathogenesis
- (2020) Yu Chen et al. JOURNAL OF MEDICAL VIROLOGY
- Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS
- (2020) Yushun Wan et al. JOURNAL OF VIROLOGY
- Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
- (2020) Roujian Lu et al. LANCET
- A new coronavirus associated with human respiratory disease in China
- (2020) Fan Wu et al. NATURE
- A pneumonia outbreak associated with a new coronavirus of probable bat origin
- (2020) Peng Zhou et al. NATURE
- The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade
- (2020) B. Coutard et al. ANTIVIRAL RESEARCH
- SARS-CoV-2–A Tough Opponent for the Immune System
- (2020) Mahsa Golshani Nasab et al. ARCHIVES OF MEDICAL RESEARCH
- Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
- (2020) Qihui Wang et al. CELL
- SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
- (2020) Carly G.K. Ziegler et al. CELL
- Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2
- (2020) Vanessa Monteil et al. CELL
- Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
- (2020) Alexandra C. Walls et al. CELL
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion
- (2020) Shuai Xia et al. CELL RESEARCH
- Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine
- (2020) Wanbo Tai et al. Cellular & Molecular Immunology
- Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?
- (2020) Daniel Batlle et al. CLINICAL SCIENCE
- A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein
- (2020) Hong Zhou et al. CURRENT BIOLOGY
- SARS-CoV-2 and COVID-19: A genetic, epidemiological, and evolutionary perspective
- (2020) Manuela Sironi et al. INFECTION GENETICS AND EVOLUTION
- Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection
- (2020) Jacques Fantini et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- COVID-19 spike-host cell receptor GRP78 binding site prediction
- (2020) Ibrahim M. Ibrahim et al. JOURNAL OF INFECTION
- Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop
- (2020) Javier A. Jaimes et al. JOURNAL OF MOLECULAR BIOLOGY
- A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells
- (2020) Markus Hoffmann et al. MOLECULAR CELL
- Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
- (2020) Jun Lan et al. NATURE
- Structural basis of receptor recognition by SARS-CoV-2
- (2020) Jian Shang et al. NATURE
- Cell entry mechanisms of SARS-CoV-2
- (2020) Jian Shang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells
- (2020) Shutoku Matsuyama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig
- (2020) Changhai Lei et al. Nature Communications
- Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection
- (2020) Xin Zou et al. Frontiers of Medicine
- Variant analysis of SARS-CoV-2 genomes
- (2020) Takahiko Koyama et al. BULLETIN OF THE WORLD HEALTH ORGANIZATION
- The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity
- (2020) Qianqian Li et al. CELL
- Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus
- (2020) Bette Korber et al. CELL
- Longitudinal analyses reveal immunological misfiring in severe COVID-19
- (2020) Carolina Lucas et al. NATURE
- Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation
- (2020) Matthew McCallum et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
- (2020) Ching-Lin Hsieh et al. SCIENCE
- Mutational Frequencies of SARS-CoV-2 Genome during the Beginning Months of the Outbreak in USA
- (2020) Neha Kaushal et al. Pathogens
- Preliminary Virtual Screening Studies to Identify GRP78 Inhibitors Which May Interfere with SARS-CoV-2 Infection
- (2020) Andreia Palmeira et al. Pharmaceuticals
- Exploring the genomic and proteomic variations of SARS-CoV-2 spike glycoprotein: A computational biology approach
- (2020) Syed Mohammad Lokman et al. INFECTION GENETICS AND EVOLUTION
- Insights into the structural and dynamical changes of spike glycoprotein mutations associated with SARS-CoV-2 host receptor binding
- (2020) Shahzaib Ahamad et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- The stress-inducible molecular chaperone GRP78 as potential therapeutic target for coronavirus infection
- (2020) Dat P. Ha et al. JOURNAL OF INFECTION
- COVID-19 pandemic: Insights into structure, function, and hACE2 receptor recognition by SARS-CoV-2
- (2020) Anshumali Mittal et al. PLoS Pathogens
- In Silico Structure-Based Repositioning of Approved Drugs for Spike Glycoprotein S2 Domain Fusion Peptide of SARS-CoV-2: Rationale from Molecular Dynamics and Binding Free Energy Calculations
- (2020) Nishant Shekhar et al. mSystems
- The Proteolytic Regulation of Virus Cell Entry by Furin and Other Proprotein Convertases
- (2019) Gonzalo Izaguirre Viruses-Basel
- Diagnosis of Feline Infectious Peritonitis: A Review of the Current Literature
- (2019) Sandra Felten et al. Viruses-Basel
- Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection
- (2019) Vineet D. Menachery et al. JOURNAL OF VIROLOGY
- Why are RNA virus mutation rates so damn high?
- (2018) Siobain Duffy PLOS BIOLOGY
- Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion
- (2017) Alexandra C. Walls et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Angiotensin Converting Enzyme 2 (ACE2), Gut Microbiota, and Cardiovascular Health
- (2017) Joao Marcus Oliveira Andrade et al. PROTEIN AND PEPTIDE LETTERS
- Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
- (2017) Yuan Yuan et al. Nature Communications
- Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding
- (2016) Miao Gui et al. CELL RESEARCH
- Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer
- (2016) Alexandra C. Walls et al. NATURE
- Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism
- (2016) Jung-Eun Park et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism
- (2016) Sven O. Dahms et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and Inflammatory Lung Disease
- (2016) Hongpeng Jia SHOCK
- Structure, Function, and Evolution of Coronavirus Spike Proteins
- (2016) Fang Li Annual Review of Virology
- KIM-1–mediated phagocytosis reduces acute injury to the kidney
- (2015) Li Yang et al. JOURNAL OF CLINICAL INVESTIGATION
- Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis
- (2015) Jean Kaoru Millet et al. VIRUS RESEARCH
- Inferring the hosts of coronavirus using dual statistical models based on nucleotide composition
- (2015) Qin Tang et al. Scientific Reports
- Coronaviruses: Important Emerging Human Pathogens
- (2014) C. M. Coleman et al. JOURNAL OF VIROLOGY
- Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein
- (2014) Jean Kaoru Millet et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Canine Enteric Coronaviruses: Emerging Viral Pathogens with Distinct Recombinant Spike Proteins
- (2014) Beth Licitra et al. Viruses-Basel
- Middle East respiratory syndrome (MERS)
- (2014) Cheston B Cunha et al. Virulence
- Wild-Type and Mutant Hemagglutinin Fusion Peptides Alter Bilayer Structure as Well as Kinetics and Activation Thermodynamics of Stalk and Pore Formation Differently: Mechanistic Implications
- (2013) Hirak Chakraborty et al. BIOPHYSICAL JOURNAL
- Middle East Respiratory Syndrome Coronavirus Infection Mediated by the Transmembrane Serine Protease TMPRSS2
- (2013) Kazuya Shirato et al. JOURNAL OF VIROLOGY
- HIV-1 gp41 Transmembrane Domain Interacts with the Fusion Peptide: Implication in Lipid Mixing and Inhibition of Virus–Cell Fusion
- (2012) Eliran Moshe Reuven et al. BIOCHEMISTRY
- Mechanisms of Host Receptor Adaptation by Severe Acute Respiratory Syndrome Coronavirus
- (2012) Kailang Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus
- (2012) P. C. Y. Woo et al. JOURNAL OF VIROLOGY
- Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
- (2012) Ali M. Zaki et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion Competence
- (2012) Taylor Heald-Sargent et al. Viruses-Basel
- Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein
- (2012) Sandrine Belouzard et al. Viruses-Basel
- A Virus-Binding Hot Spot on Human Angiotensin-Converting Enzyme 2 Is Critical for Binding of Two Different Coronaviruses
- (2011) K. Wu et al. JOURNAL OF VIROLOGY
- Fusion Peptide from Influenza Hemagglutinin Increases Membrane Surface Order: An Electron-Spin Resonance Study
- (2009) Mingtao Ge et al. BIOPHYSICAL JOURNAL
- The spike protein of SARS-CoV — a target for vaccine and therapeutic development
- (2009) Lanying Du et al. NATURE REVIEWS MICROBIOLOGY
- Coronaviruses post-SARS: update on replication and pathogenesis
- (2009) Stanley Perlman et al. NATURE REVIEWS MICROBIOLOGY
- Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites
- (2009) S. Belouzard et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Membrane insertion of the three main membranotropic sequences from SARS-CoV S2 glycoprotein
- (2008) Jaime Guillén et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Structural Analysis of Major Species Barriers between Humans and Palm Civets for Severe Acute Respiratory Syndrome Coronavirus Infections
- (2008) F. Li JOURNAL OF VIROLOGY
- Viral membrane fusion
- (2008) Stephen C Harrison NATURE STRUCTURAL & MOLECULAR BIOLOGY
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