期刊
FOOD CHEMISTRY
卷 211, 期 -, 页码 860-868出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2016.05.122
关键词
Anthocyanin; Polyphenol; Aronia; Pharmacokinetic; Metabolism; UHPLC-MS; Cyanidin; Ferulic acid
资金
- Connecticut Department of Public Health
A single-dose pharmacokinetic trial was conducted in 6 adults to evaluate the bioavailability of anthocyanins and colonic polyphenol metabolites after consumption of 500 mg aronia berry extract. UHPLC-MS methods were developed to quantitate aronia berry polyphenols and their metabolites in plasma and urine. While anthocyanins were bioavailable, microbial phenolic catabolites increased similar to 10-fold more than anthocyanins in plasma and urine. Among the anthocyanins, cyanidin-3-O-galactoside was rapidly metabolized to peonidin-3-O-galactoside. Aronia polyphenols were absorbed and extensively metabolized with t(max) of anthocyanins and other polyphenol catabolites from 1.0 h to 6.33 h in plasma and urine. Despite significant inter-individual variation in pharmacokinetic parameters, concentrations of polyphenol metabolites in plasma and urine at 24 h were positively correlated with total AUC in plasma and urine (r = 0.93, and r = 0.98, respectively). This suggests that fasting blood and urine collections could be used to estimate polyphenol bioavailability and metabolism after aronia polyphenol consumption. (C) 2016 Elsevier Ltd. All rights reserved.
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