Protein degradation: a novel computational approach to design protein degrader probes for main protease of SARS-CoV-2

Rationalizing PROTAC-Mediated Ternary Complex Formation Using Rosetta

(2021) Nan Bai et al.   Journal of Chemical Information and Modeling

A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease

(2021) Jeremy D. Baker et al.   PLoS One

Emerging coronaviruses: Genome structure, replication, and pathogenesis

(2020) Yu Chen et al.   JOURNAL OF MEDICAL VIROLOGY

Light-induced control of protein destruction by opto-PROTAC

(2020) Jing Liu et al.   Science Advances

PHOTACs enable optical control of protein degradation

(2020) Martin Reynders et al.   Science Advances

Expanding our understanding of the role polyprotein conformation plays in the coronavirus life cycle

(2020) Samantha Gildenhuys   BIOCHEMICAL JOURNAL

Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown

(2020) Yu-Hui Jin et al.   JOURNAL OF MEDICINAL CHEMISTRY

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Repurposing antimalarials and other drugs for COVID-19

(2020) Patricia Schlagenhauf et al.   Travel Medicine and Infectious Disease

Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease

(2020) Brendan T Freitas et al.   ACS Infectious Diseases

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2

(2020) Yadi Zhou et al.   Cell Discovery

The Development of Coronavirus 3C-Like Protease (3CLpro) Inhibitors from 2010 to 2020

(2020) Yuzhi Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

(2020) Laura Riva et al.   NATURE

Could PROTACs Protect Us From COVID-19?

(2020) Wilnelly Martinez-Ortiz et al.   DRUG DISCOVERY TODAY

Remdesivir: First Approval

(2020) Yvette N. Lamb   DRUGS

PRosettaC: Rosetta Based Modeling of PROTAC Mediated Ternary Complexes

(2020) Daniel Zaidman et al.   Journal of Chemical Information and Modeling

Improved Accuracy for Modeling PROTAC-Mediated Ternary Complex Formation and Targeted Protein Degradation via New In Silico Methodologies

(2020) Michael L. Drummond et al.   Journal of Chemical Information and Modeling

Malleability of the SARS-CoV-2 3CL Mpro active site cavity facilitates binding of clinical antivirals

(2020) Daniel W. Kneller et al.   STRUCTURE

An integrated drug repurposing strategy for the rapid identification of potential SARS-CoV-2 viral inhibitors

(2020) Alfonso Trezza et al.   Scientific Reports

Evaluation of acridinedione analogs as potential SARS-CoV-2 main protease inhibitors and their comparison with repurposed anti-viral drugs

(2020) Vijay Kumar Bhardwaj et al.   COMPUTERS IN BIOLOGY AND MEDICINE

ARV-110: An oral androgen receptor PROTAC degrader for prostate cancer.

(2019) Taavi Neklesa et al.   JOURNAL OF CLINICAL ONCOLOGY

In Silico Modeling of PROTAC-Mediated Ternary Complexes: Validation and Application

(2019) Michael L. Drummond et al.   Journal of Chemical Information and Modeling

HawkDock: a web server to predict and analyze the protein–protein complex based on computational docking and MM/GBSA

(2019) Gaoqi Weng et al.   NUCLEIC ACIDS RESEARCH

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations

(2019) Mélissanne de Wispelaere et al.   Nature Communications

Light-Induced Protein Degradation with Photocaged PROTACs

(2019) Gang Xue et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-Based Design of a Macrocyclic PROTAC

(2019) Andrea Testa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein

(2019) Haibin Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting the C481S Ibrutinib-Resistance Mutation in Bruton’s Tyrosine Kinase Using PROTAC-Mediated Degradation

(2018) Alexandru D. Buhimschi et al.   BIOCHEMISTRY

Plasticity in binding confers selectivity in ligand-induced protein degradation

(2018) Radosław P. Nowak et al.   Nature Chemical Biology

Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation

(2018) Philipp M. Cromm et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

UniProt: a worldwide hub of protein knowledge

(2018)   NUCLEIC ACIDS RESEARCH

Pathological role of a point mutation (T315I) in BCR-ABL1 protein-A computational insight

(2017) Vidya Rajendran et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design

(2017) Rebecca F. Alford et al.   Journal of Chemical Theory and Computation

Structural basis of PROTAC cooperative recognition for selective protein degradation

(2017) Morgan S Gadd et al.   Nature Chemical Biology

Targeted protein degradation by PROTACs

(2017) Taavi K. Neklesa et al.   PHARMACOLOGY & THERAPEUTICS

Impact of point mutation P29S in RAC1 on tumorigenesis

(2016) Vidya Rajendran et al.   TUMOR BIOLOGY

Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras

(2016) Honorine Lebraud et al.   ACS Central Science

Catalytic in vivo protein knockdown by small-molecule PROTACs

(2015) Daniel P Bondeson et al.   Nature Chemical Biology

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

The Chromosome-Centric Human Proteome Project for cataloging proteins encoded in the genome

(2012) Young-Ki Paik et al.   NATURE BIOTECHNOLOGY

Benchmarking and Analysis of Protein Docking Performance in Rosetta v3.2

(2011) Sidhartha Chaudhury et al.   PLoS One