标题
Structure-Based Design of a Macrocyclic PROTAC
作者
关键词
-
出版物
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 4, Pages 1727-1734
出版商
Wiley
发表日期
2019-11-20
DOI
10.1002/anie.201914396
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6
- (2019) Baishan Jiang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate
- (2019) Michael J. Roy et al. ACS Chemical Biology
- BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
- (2019) William Farnaby et al. Nature Chemical Biology
- Bifunctional chemical probes inducing protein–protein interactions
- (2019) Chiara Maniaci et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Targeted protein degradation and the enzymology of degraders
- (2018) Stewart L Fisher et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Plasticity in binding confers selectivity in ligand-induced protein degradation
- (2018) Radosław P. Nowak et al. Nature Chemical Biology
- Delineating the role of cooperativity in the design of potent PROTACs for BTK
- (2018) Adelajda Zorba et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Optimization of a “bump-and-hole” approach to allele-selective BET bromodomain inhibition
- (2018) A. C. Runcie et al. Chemical Science
- Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action
- (2018) Kristin M. Riching et al. ACS Chemical Biology
- Structure-based drug design: aiming for a perfect fit
- (2017) Rob L.M. van Montfort et al. Essays in Biochemistry
- Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders
- (2017) Scott J. Hughes et al. Essays in Biochemistry
- Stabilization of protein-protein interactions in drug discovery
- (2017) Sebastian A. Andrei et al. Expert Opinion on Drug Discovery
- Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?
- (2017) Ian Churcher JOURNAL OF MEDICINAL CHEMISTRY
- Structural basis of PROTAC cooperative recognition for selective protein degradation
- (2017) Morgan S Gadd et al. Nature Chemical Biology
- Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
- (2015) Michael Zengerle et al. ACS Chemical Biology
- Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4
- (2015) Jing Lu et al. CHEMISTRY & BIOLOGY
- Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein Interactions
- (2015) Teresa A. F. Cardote et al. ChemMedChem
- Catalytic in vivo protein knockdown by small-molecule PROTACs
- (2015) Daniel P Bondeson et al. Nature Chemical Biology
- Phthalimide conjugation as a strategy for in vivo target protein degradation
- (2015) G. E. Winter et al. SCIENCE
- How proteins bind macrocycles
- (2014) Elizabeth A Villar et al. Nature Chemical Biology
- A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes
- (2014) M. G. J. Baud et al. SCIENCE
- Rapamycin passes the torch: a new generation of mTOR inhibitors
- (2011) Don Benjamin et al. NATURE REVIEWS DRUG DISCOVERY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started