Gene body methylation safeguards ribosomal DNA transcription by preventing PHF6-mediated enrichment of repressive histone mark H4K20me3

Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription.

(2018) Sarmila Majumder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer

(2018) Maria Arechederra et al.   Nature Communications

PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes

(2017) Yadira M. Soto-Feliciano et al.   GENES & DEVELOPMENT

SF-KDM2A binds to ribosomal RNA gene promoter, reduces H4K20me3 level, and elevates ribosomal RNA transcription in breast cancer cells

(2017) Kengo Okamoto et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Intragenic DNA methylation prevents spurious transcription initiation

(2017) Francesco Neri et al.   NATURE

The sub-nucleolar localization of PHF6 defines its role in rDNA transcription and early processing events

(2016) Matthew A M Todd et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A genome-scale in vivo loss-of-function screen identifiesPhf6as a lineage-specific regulator of leukemia cell growth

(2015) Corbin E. Meacham et al.   GENES & DEVELOPMENT

Structural Basis of Plant Homeodomain Finger 6 (PHF6) Recognition by the Retinoblastoma Binding Protein 4 (RBBP4) Component of the Nucleosome Remodeling and Deacetylase (NuRD) Complex

(2015) Zhonghua Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells

(2015) Jing Liao et al.   NATURE GENETICS

BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase

(2015) Abid Khan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer

(2014) Xiaojing Yang et al.   CANCER CELL

Structural and Functional Insights into the Human Börjeson-Forssman-Lehmann Syndrome-associated Protein PHF6

(2014) Zhonghua Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quiescence-Induced LncRNAs Trigger H4K20 Trimethylation and Transcriptional Silencing

(2014) Holger Bierhoff et al.   MOLECULAR CELL

DNA methylation: roles in mammalian development

(2013) Zachary D. Smith et al.   NATURE REVIEWS GENETICS

The X-Linked Intellectual Disability Protein PHF6 Associates with the PAF1 Complex and Regulates Neuronal Migration in the Mammalian Brain

(2013) Chi Zhang et al.   NEURON

PHF6 Regulates Cell Cycle Progression by Suppressing Ribosomal RNA Synthesis

(2012) Jiadong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PHF6 Interacts with the Nucleosome Remodeling and Deacetylation (NuRD) Complex

(2012) Matthew A. M. Todd et al.   JOURNAL OF PROTEOME RESEARCH

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions

(2012) W. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic changes in the human methylome during differentiation

(2010) L. Laurent et al.   GENOME RESEARCH

Replication timing-related and gene body-specific methylation of active human genes

(2010) Dvir Aran et al.   HUMAN MOLECULAR GENETICS

PHF6 mutations in adult acute myeloid leukemia

(2010) P Van Vlierberghe et al.   LEUKEMIA

MOF and Histone H4 Acetylation at Lysine 16 Are Critical for DNA Damage Response and Double-Strand Break Repair

(2010) G. G. Sharma et al.   MOLECULAR AND CELLULAR BIOLOGY

PHF6 mutations in T-cell acute lymphoblastic leukemia

(2010) Pieter Van Vlierberghe et al.   NATURE GENETICS

Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes

(2010) H. Wu et al.   SCIENCE

Epigenetic Reprogramming in Plant and Animal Development

(2010) Suhua Feng et al.   SCIENCE

Loss of Human Ribosomal Gene CpG Methylation Enhances Cryptic RNA Polymerase II Transcription and Disrupts Ribosomal RNA Processing

(2009) Thérèse Gagnon-Kugler et al.   MOLECULAR CELL

Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells

(2009) Madeleine P Ball et al.   NATURE BIOTECHNOLOGY

A human B cell methylome at 100−base pair resolution

(2009) Tibor A. Rauch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclical DNA methylation of a transcriptionally active promoter

(2008) Raphaël Métivier et al.   NATURE

Transient cyclical methylation of promoter DNA

(2008) Sara Kangaspeska et al.   NATURE

DNA methylation landscapes: provocative insights from epigenomics

(2008) Miho M. Suzuki et al.   NATURE REVIEWS GENETICS