Bacterial Cytological Profiling Identifies Rhodanine-Containing PAINS Analogs as Specific Inhibitors of Escherichia coli Thymidylate Kinase In Vivo

Bacterial Cytological Profiling as a Tool To Study Mechanisms of Action of Antibiotics That Are Active against Acinetobacter baumannii

(2019) Htut Htut Htoo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Crossroads of Antibiotic Resistance and Biosynthesis

(2019) Timothy A. Wencewicz   JOURNAL OF MOLECULAR BIOLOGY

Rapid Inhibition Profiling identifies a keystone target in the nucleotide biosynthesis pathway

(2018) Christine E. Peters et al.   ACS Chemical Biology

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Antibiotic resistance

(2017) Marianne Frieri et al.   Journal of Infection and Public Health

Rapid Inhibition Profiling in Bacillus subtilis to Identify the Mechanism of Action of New Antimicrobials

(2016) Anne Lamsa et al.   ACS Chemical Biology

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

First Report of Ceftazidime-Avibactam Resistance in a KPC-3-Expressing Klebsiella pneumoniae Isolate

(2015) Romney M. Humphries et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Appropriate antimicrobial therapy in the era of multidrug-resistant human pathogens

(2015) J.M. Pogue et al.   CLINICAL MICROBIOLOGY AND INFECTION

Application of bacterial cytological profiling to crude natural product extracts reveals the antibacterial arsenal of Bacillus subtilis

(2015) Poochit Nonejuie et al.   JOURNAL OF ANTIBIOTICS

Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It

(2015) Helen I. Zgurskaya et al.   ACS Infectious Diseases

Antibiotic resistance: An infectious arms race

(2014) Karyn Hede   NATURE

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Bacterial cytological profiling rapidly identifies the cellular pathways targeted by antibacterial molecules

(2013) P. Nonejuie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound

(2012) Thomas A. Keating et al.   ACS Chemical Biology

Rhodanine as a scaffold in drug discovery: a critical review of its biological activities and mechanisms of target modulation

(2012) Tihomir Tomašić et al.   Expert Opinion on Drug Discovery

Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK)

(2012) Gabriel Martínez-Botella et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Bacillus subtilis cannibalism toxin SDP collapses the proton motive force and induces autolysis

(2012) Anne Lamsa et al.   MOLECULAR MICROBIOLOGY

Discovery research: the scientific challenge of finding new antibiotics

(2011) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Principles of early drug discovery

(2010) JP Hughes et al.   BRITISH JOURNAL OF PHARMACOLOGY

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY