Soluble Amyloid-β Consumption in Alzheimer’s Disease

Findings of Efficacy, Safety, and Biomarker Outcomes of Atabecestat in Preclinical Alzheimer Disease

(2021) Reisa Sperling et al.   JAMA Neurology

Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial

(2021) Günter U Höglinger et al.   LANCET NEUROLOGY

Donanemab in Early Alzheimer’s Disease

(2021) Mark A. Mintun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis

(2021) Sarah F Ackley et al.   BMJ-British Medical Journal

The Amyloid, Tau, and Neurodegeneration (A/T/N) Classification Applied to a Clinical Research Cohort with Long-Term Follow-Up

(2020) Gøril Rolfseng Grøntvedt et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid β-protein and beyond: the path forward in Alzheimer’s disease

(2020) Dominic M Walsh et al.   CURRENT OPINION IN NEUROBIOLOGY

Kinetic diversity of amyloid oligomers

(2020) Alexander J. Dear et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology

(2020) Maja Malmberg et al.   Frontiers in Neuroscience

A 3D human brain–like tissue model of herpes-induced Alzheimer’s disease

(2020) Dana M. Cairns et al.   Science Advances

The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics

(2020) Sarah A. Kent et al.   ACTA NEUROPATHOLOGICA

Alzheimer’s disease beyond amyloid: Can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery?

(2020) Kevin Mullane et al.   BIOCHEMICAL PHARMACOLOGY

Shifts and drifts in prion science

(2020) Adriano Aguzzi et al.   SCIENCE

Failure of first anti-tau antibody in Alzheimer disease highlights risks of history repeating

(2020) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases

(2019) Alberto J. Espay et al.   NEUROLOGY

The metabolic brain signature of cognitive resilience in the 80+: beyond Alzheimer pathologies

(2019) Eider M Arenaza-Urquijo et al.   BRAIN

The viral protein corona directs viral pathogenesis and amyloid aggregation

(2019) Kariem Ezzat et al.   Nature Communications

Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework

(2019) Clifford R. Jack et al.   JAMA Neurology

Questions EMERGE as Biogen claims aducanumab turnaround

(2019) Robert Howard et al.   Nature Reviews Neurology

A resurrection of aducanumab for Alzheimer's disease

(2019) Lon Schneider   LANCET NEUROLOGY

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes

(2018) Johnny Habchi et al.   Nature Chemistry

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(2018) Jeffrey L. Cummings et al.   NEUROLOGY

Memory decline accompanies subthreshold amyloid accumulation

(2018) Susan M. Landau et al.   NEUROLOGY

Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan

(2018) Nian-Sheng Tzeng et al.   Neurotherapeutics

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

(2018) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Load of Amyloid-β Oligomers is Decreased in the Cerebrospinal Fluid of Alzheimer's Disease Patients

(2018) Giulia M. Sancesario et al.   JOURNAL OF ALZHEIMERS DISEASE

Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease

(2018) Eric McDade et al.   NEUROLOGY

The antimicrobial protection hypothesis of Alzheimer's disease

(2018) Robert D. Moir et al.   Alzheimers & Dementia

Regional amyloid accumulation and cognitive decline in initially amyloid-negative adults

(2018) Michelle E. Farrell et al.   NEUROLOGY

Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons

(2017) Michael C. Donohue et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα

(2017) Bruce G. Mockett et al.   Frontiers in Molecular Neuroscience

Alzheimer disease: modeling an Aβ-centered biological network

(2016) D Campion et al.   MOLECULAR PSYCHIATRY

The activities of amyloids from a structural perspective

(2016) Roland Riek et al.   NATURE

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

(2016) Clifford R. Jack et al.   NEUROLOGY

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model

(2015) Romain Fol et al.   ACTA NEUROPATHOLOGICA

Immunotherapies in Alzheimer’s disease: Too much, too little, too late or off-target?

(2015) Isabelle St-Amour et al.   ACTA NEUROPATHOLOGICA

The Neuropathology of Chronic Traumatic Encephalopathy

(2015) Ann C. McKee et al.   BRAIN PATHOLOGY

Role of Amylin in Type 1 and Type 2 Diabetes

(2015) Laura Hieronymus et al.   DIABETES EDUCATOR

The association between infectious burden and Parkinson's disease: A case-control study

(2015) Xian-Le Bu et al.   PARKINSONISM & RELATED DISORDERS

Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons

(2015) Maria L. Giuffrida et al.   Frontiers in Cellular Neuroscience

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

Altered Cerebrospinal Fluid Levels of Amyloid β and Amyloid Precursor-Like Protein 1 Peptides in Down’s Syndrome

(2014) Erik Portelius et al.   NEUROMOLECULAR MEDICINE

Effect of Proline Mutations on the Monomer Conformations of Amylin

(2013) Chi-cheng Chiu et al.   BIOPHYSICAL JOURNAL

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Cerebrospinal fluid Aβ42 is the best predictor of clinical progression in patients with subjective complaints

(2012) Argonde C. van Harten et al.   Alzheimers & Dementia

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Alzheimer disease pathology and longitudinal cognitive performance in the oldest-old with no dementia

(2012) A. B. Balasubramanian et al.   NEUROLOGY

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amyloid-β associated volume loss occurs only in the presence of phospho-tau

(2011) Rahul S. Desikan et al.   ANNALS OF NEUROLOGY

Cognitive reserve and Alzheimer's disease biomarkers are independent determinants of cognition

(2011) Prashanthi Vemuri et al.   BRAIN

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

(2009) Leslie M. Shaw et al.   ANNALS OF NEUROLOGY

 -Amyloid Monomers Are Neuroprotective

(2009) M. L. Giuffrida et al.   JOURNAL OF NEUROSCIENCE

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

APOE  2 is associated with intact cognition but increased Alzheimer pathology in the oldest old

(2009) D. J. Berlau et al.   NEUROLOGY