Article
Biochemistry & Molecular Biology
Mohammad Irshad Reza, Anees A. Syed, Sanjana Kumariya, Pragati Singh, Athar Husain, Jiaur R. Gayen
Summary: The research suggests that PST can induce the aggregation of IAPP in the pancreas, liver, and skeletal muscle, potentially leading to insulin resistance and type 2 diabetes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Endocrinology & Metabolism
Ana Garcia-Aguilar, Carlos Guillen
Summary: Diabetes is a complex disease characterized by the increase and subsequent apoptosis of pancreatic beta cells. Various conditions can affect the homeostasis and viability of the beta cells. It has been found that different polyphenols may have regulatory effects on these mechanisms, offering potential for diabetes treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Food Science & Technology
Noah Leibold, James R. Bain, Florin Despa
Summary: Type-2 diabetes is linked to an increased risk of Alzheimer's disease and the conversion to dementia from mild cognitive impairment, but the mechanisms connecting the two remain unclear. Amylin, a hormone co-secreted with insulin, is implicated in both satiation regulation and the formation of amyloid in the pancreas. It also interacts with amyloid beta pathology in Alzheimer's disease, suggesting a potential role in neuronal metabolic remodeling.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Medicine, General & Internal
Juan P. Frias, Srikanth Deenadayalan, Lars Erichsen, Filip K. Knop, Ildiko Lingvay, Stanislava Macura, Chantal Mathieu, Sue Pedersen, Melanie Davies
Summary: This study assessed the efficacy and safety of co-administered semaglutide with cagrilintide in participants with type 2 diabetes. The results showed that the combination treatment resulted in clinically relevant improvements in glycemic control and weight loss compared to cagrilintide alone, and it was well tolerated.
Review
Endocrinology & Metabolism
Annika Rosengren, Pigi Dikaiou
Summary: Diabetes is a highly prevalent cardiometabolic disorder associated with cardiovascular disease and premature death. The type of diabetes that carries the highest risk of these outcomes is still controversial and lacks extensive research. The rise in type 2 diabetes prevalence has significant global health implications due to its association with cardiovascular disease.
Review
Biochemistry & Molecular Biology
Rosanna Capparelli, Domenico Iannelli
Summary: Epigenetic marks the genome through DNA methylation, histone modification, or non-coding RNAs, guiding cells to respond to environmental cues and maintain stable gene expression. Studies have revealed associations between DNA methylation and conditions such as body mass index, obesity, and Type 2 Diabetes, highlighting the potential therapeutic value of epigenetic research.
Article
Immunology
Anne-Cathrine S. Vogt, Elisa S. Roesti, Mona O. Mohsen, Ainars Leonchiks, Monique Vogel, Martin F. Bachmann
Summary: Type 2 Diabetes Mellitus is a chronic progressive disease characterized by insulin resistance and insufficient insulin secretion. Research suggests that monoclonal antibody therapy targeting amyloidogenic aggregates may be a potential treatment for T2DM.
Article
Endocrinology & Metabolism
Laura del Bosque-Plata, Eduardo Martinez-Martinez, Miguel Angel Espinoza-Camacho, Claudia Gragnoli
Summary: TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and is consistently associated with the disease across diverse populations with different genetic origins. The exact mechanisms by which TCF7L2 affects T2D are still not well understood.
Review
Immunology
Joanne Boldison, F. Susan Wong
Summary: Regulatory B cells (Bregs) play an anti-inflammatory role through both cytokine secretion and cell-contact mediated mechanisms. While IL-10 secretion is a hallmark feature of Bregs, IL-35 and TGF beta-producing B cells have also been identified. Reports identifying impaired frequency or function of Bregs in individuals with type 1 diabetes are limited, leading to a restricted understanding of the role played by these Breg subsets in the pathogenesis of the condition.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Antea DeMarsilis, Niyoti Reddy, Chrysoula Boutari, Andreas Filippaios, Elliot Sternthal, Niki Katsiki, Christos Mantzoros
Summary: This review provides an updated summary of the pharmacotherapeutic approach to type 2 diabetes (T2D), including the mechanism of action, administration details, side effect profile, cost, and use in specific populations of different classes of agents. It also reviews the targets of novel therapeutic T2D agent development. Finally, it outlines a contemporary treatment approach starting with the identification of an individualized glycemic control goal, followed by the selection, initiation, and further intensification of a personalized therapeutic plan for T2D.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Endocrinology & Metabolism
Emil F. Coccaro, Sophie Lazarus, Joshua Joseph, Kathline Wyne, Tina Drossos, Louis Phillipson, Mary de Groot
Summary: The study found that negative emotional experience is positively related to diabetes-related distress, while the skill at regulating these emotions is negatively related to diabetes-related distress, with a medium-size relationship between these emotional regulation variables and diabetes-related distress. The data suggest that diabetes-related distress in adults with diabetes is meaningfully linked to negative emotionality and skill at regulating such emotions, with a stronger relationship than perceived psychological stress or diabetes self-care.
Article
Endocrinology & Metabolism
Nathaniel M. Putnam, Evan L. Reynolds, Mousumi Banerjee, Kara Mizokami-Stout, Dana Albright, Joyce Lee, Rodica Pop-Busui, Eva L. Feldman, Brian C. Callaghan
Summary: This study aimed to compare the neuropsychological outcomes of individuals with different types of diabetes and those without diabetes. Results showed that individuals with type 2 diabetes had the highest prevalence of neuropsychological outcomes, but the presence of microvascular/macrovascular complications significantly increased the risk for all patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Vikas S. Sridhar, Christine P. Limonte, Per-Henrik Groop, Hiddo J. L. Heerspink, Richard E. Pratley, Peter Rossing, Jay S. Skyler, David Z. I. Cherney
Summary: The current management of CKD in type 1 diabetes focuses on blood sugar control, inhibiting the renin-angiotensin system and optimizing risk factors. However, individuals with type 1 diabetes and CKD still face elevated risks for kidney and cardiovascular events. Novel therapies used in type 2 diabetes, such as sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide 1 receptor agonists, have shown potential kidney and heart protection. Applying these therapies to individuals with type 1 diabetes for the prevention of CKD is of great importance.
Review
Chemistry, Multidisciplinary
Sabine Szunerits, Amar Abderrahmani, Rabah Boukherroub
Summary: Nanotechnology is revolutionizing human medicine, with nanoparticles (NPs) showing great potential in treating various diseases. The interaction between NPs and proteins plays a crucial role in inhibiting protein aggregation and fibrillation of amyloid proteins. This inhibition represents a new generation of innovative medicines to combat metabolic diseases such as type 2 diabetes. Advances in understanding S-cells and the formation of amylin oligomers and aggregates under diabetic conditions are discussed, and the potential of carbon nanocolloids in reversing protein aggregation is highlighted.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Anna Giovenzana, Debora Carnovale, Brett Phillips, Alessandra Petrelli, Nick Giannoukakis
Summary: Research indicates that neutrophils play a significant role in the pathogenesis of diabetes mellitus, particularly type 1 and type 2 diabetes, by being the first white blood cells to react and accumulate in target tissues. Their functional alteration, including NETosis, contributes to disease progression. Potential therapeutic approaches focus on limiting neutrophil-mediated damage to prevent subclinical disease from progressing to clinical hyperglycaemia.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)