Article
Environmental Sciences
Sridhar Chinthakindi, Kurunthachalam Kannan
Summary: In this study, the concentrations of 30 primary aromatic amines (AAs), nicotine, and cotinine were measured in urine samples collected over a five-week period from 15 participants. The study found that eight AAs were detected in urine with varying frequencies, and their concentrations showed temporal variability within and between individuals. Gender and ethnicity were found to have significant effects on the concentrations of AAs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Sridhar Chinthakindi, Kurunthachalam Kannan
Summary: Primary aromatic amines (AAs) and tobacco smoke markers were found to be prevalent in indoor house dust samples from 10 countries, with concentrations varying significantly between countries. Aniline was identified as the most abundant contaminant among AAs, while nicotine was consistently detected in all indoor samples. Concentrations of AAs in house dust were strongly correlated with nicotine levels.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Sridhar Chinthakindi, Qingqing Zhu, Chunyang Liao, Kurunthachalam Kannan
Summary: This study investigated the occurrence of 35 primary aromatic amines and two tobacco chemical markers in 119 samples of house dust collected from five provinces in China, finding that most samples contained these chemicals, with higher concentrations in Henan and Shanxi provinces. Significant positive correlations were observed between concentrations of nicotine and aromatic amines in the dust samples.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Applied
Yukun Huang, Yaning Song, Fang Chen, Zhenju Jiang, Zhenming Che, Xiao Yang, Xianggui Chen
Summary: A UHPLC-MS/MS method was developed for the simultaneous determination of eight biogenic amines in Pixian Douban. The study found potential pollution of biogenic amines in chili oil Pixian Douban, based on the analysis of 19 samples using the developed method.
Article
Biochemical Research Methods
Sridhar Chinthakindi, Kurunthachalam Kannan
Summary: A bioanalytical method utilizing liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed to determine trace levels of 39 primary aromatic amines and nicotine/cotinine in human urine. The method demonstrated excellent linear dynamic range and precision, and was successfully applied in the analysis of urine samples from the general population and known smokers.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Biochemical Research Methods
M. M. Arce, D. Castro, L. A. Sarabia, M. C. Ortiz, S. Sanllorente
Summary: The purpose of this study is to develop a tool for searching gradient profiles in liquid chromatography with ternary or binary mixtures, to achieve well-resolved chromatograms in the shortest time for multianalyte analysis. The method is experimental-based and does not require a retention time model. The detection capability of the method has been evaluated for the quantification of four primary aromatic amines.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Environmental Sciences
Sridhar Chinthakindi, Kurunthachalam Kannan
Summary: This study investigated the presence of AAs and tobacco chemical markers in pet urine and feces samples. The findings suggested that pets are exposed to AAs, but have low concentrations of nicotine and cotinine. Cats and dogs are more likely to be exposed to AA precursors.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Chemistry, Applied
Wei Jia, Ruiting Li, Xixuan Wu, Li Liu, Shuxing Liu, Lin Shi
Summary: This study quantified the changes in lipid metabolism of Tan sheep under cold chain storage conditions and observed transient increases in certain lipid subclasses followed by subsequent declines or increases during the storage period. These findings provide insights into the lipid transformation and quality of Tan sheep during cold chain storage.
Article
Plant Sciences
Xuanhao Chen, Xiaoyan Wang, Lin Ma, Shiming Fang, Jin Li, Evans Owusu Boadi, Jun He, Xiu-mei Gao, Yu Wang, Yan-xu Chang
Summary: The study investigated the pharmacokinetics and mechanisms of absorbed components of Viticis fructus (VF) in rat plasma through a combination of network pharmacology and UHPLC-MS/MS. Results showed significant differences in pharmacokinetic parameters of key components between aqueous and ethanolic extracts of VF, with potential anti-cancer effects related to 15 pathways identified through network pharmacology analysis. In vitro experiments confirmed the anti-cancer effects and signaling pathways of VF extracts and absorbed components.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Sasa Savic, Sanja Petrovic, Sanela Savic, Nebojsa Cekic
Summary: This study aimed to identify N-alkylamides from commercial Acmella oleracea extract, assess their UV-B photostability in various solvents, and identify degradation products. The results showed that spilanthol and homospilanthol were the most stable N-alkylamides, while 6,9-dihydroxy-deca-2,7-dienoic acid isobutyl-amide and 8,9-dihydroxy-deca-2,6-dienoic acid isobutyl-amide were identified as the main degradation products in all solutions tested.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Medicine, Research & Experimental
Zijun Yang, Dan Wang, Yuanyuan Li, Xinfeng Zhou, Tiantian Liu, Chang Shi, Rongshan Li, Yanwen Zhang, Jun Zhang, Jiuxing Yan, Xuehui Zhu, Ying Li, Min Gong, Chongzhi Wang, Chunsu Yuan, Yan Cui, Xiaohui Wu
Summary: The study investigated the effects of red ginseng extract on T2DM rats through untargeted metabolomics, showing significant improvements in cholesterol, glucose, and insulin levels. Metabolomics analysis revealed that red ginseng may mediate its beneficial effects on T2DM by regulating metabolic pathways such as D-arginine and D-ornithine metabolism.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Ren-jie Luo, Qin-bao Lin, Lei Zhu, Jian-wei Yan, Zhong Li
Summary: This study investigates the migration behavior of polyaromatic acids (PAAs) in flexible packaging composite materials using different solvents for extraction. An effective HPLC method is proposed to screen and separate 25 kinds of PAAs. The experiments confirm the presence of PAAs in polyurethane ink and UV-ink, and corona treatment improves printing capacity but has no effect on migration quantity.
FOOD PACKAGING AND SHELF LIFE
(2022)
Article
Chemistry, Multidisciplinary
Jadwiga Nowak, Anna K. Kiss, Charles Wambebe, Esther Katuura, Lukasz Kuzma
Summary: This study employed chromatographic and spectroscopic techniques to identify and quantify polyphenolic compounds in Vernonia amygdalina leaf extract. The results revealed the presence of seven polyphenols, with 3,5-O-dicaffeoylquinic acid being the most abundant. These polyphenolic compounds may have therapeutic potential in terms of antibacterial, cytotoxic, anticancer, and antioxidant effects.
APPLIED SCIENCES-BASEL
(2022)
Article
Plant Sciences
Xiaoyin Ye, Tong Zhang, Han Han
Summary: This study investigated the absorption and pharmacokinetic behaviors of compounds in Swertia cincta using advanced analytical techniques.
Article
Food Science & Technology
Zilin Li, Hongkang Zhu, Hanyi Hua, Chang Liu, Yuliang Cheng, Yahui Guo, Peng Du, He Qian
Summary: In this study, Brassica rapa L. extract (BE) was found to enhance exercise performance and alleviate fatigue in mice. The anti-fatigue effects of BE were attributed to its ability to regulate blood markers, antioxidant levels, and energy-related substances.