Glutathione and Related Molecules in Parkinsonism

Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats

(2021) Nathalie Van Den Berge et al.   BRAIN

Glutathione in the Brain

(2021) Koji Aoyama   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response

(2021) Alberto Delaidelli et al.   Acta Neuropathologica Communications

Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice

(2020) Collin Challis et al.   NATURE NEUROSCIENCE

Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection

(2020) Yao Wei et al.   Nature Communications

Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates

(2020) Marie-Laure Arotcarena et al.   BRAIN

Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation

(2020) Fiona Limanaqi et al.   Antioxidants

Mirtazapine exerts astrocyte-mediated dopaminergic neuroprotection

(2020) Ryo Kikuoka et al.   Scientific Reports

Region-Specific Neuroprotective Features of Astrocytes against Oxidative Stress Induced by 6-Hydroxydopamine

(2019) Masato Asanuma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

(2019) Sangjune Kim et al.   NEURON

Brain-First versus Gut-First Parkinson’s Disease: A Hypothesis

(2019) Per Borghammer et al.   Journal of Parkinsons Disease

Dopaminergic neuroprotective effects of rotigotine via 5-HT1A receptors: Possibly involvement of metallothionein expression in astrocytes

(2019) Nami Isooka et al.   NEUROCHEMISTRY INTERNATIONAL

Therapeutic Strategy of Targeting Astrocytes for Neuroprotection in Parkinson's Disease

(2018) Ikuko Miyazaki et al.   CURRENT PHARMACEUTICAL DESIGN

The gut-brain axis in Parkinson's disease: Possibilities for food-based therapies

(2017) Paula Perez-Pardo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Zonisamide attenuates lactacystin-induced parkinsonism in mice without affecting system x c −

(2017) Eduard Bentea et al.   EXPERIMENTAL NEUROLOGY

Phase IIb Study of Intranasal Glutathione in Parkinson’s Disease

(2017) Laurie K. Mischley et al.   Journal of Parkinsons Disease

3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of l-DOPA

(2016) Masato Asanuma et al.   BMC NEUROSCIENCE

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

L-Theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes

(2016) Mika Takeshima et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals

(2016) Si Qin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Neuroprotective effect of fermented papaya preparation by activation of Nrf2 pathway in astrocytes

(2016) Shinki Murakami et al.   NUTRITIONAL NEUROSCIENCE

Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician’s Expectation Be Matched by the Reality?

(2016) Christine A. Houghton et al.   Oxidative Medicine and Cellular Longevity

Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2 and autophagy pathways

(2016) Qian Zhou et al.   Scientific Reports

Vagotomy and subsequent risk of Parkinson's disease

(2015) Elisabeth Svensson et al.   ANNALS OF NEUROLOGY

Neuroprotective effects of levetiracetam target xCT in astrocytes in parkinsonian mice

(2015) Ikuko Miyazaki et al.   JOURNAL OF NEUROCHEMISTRY

6-Hydroxydopamine and lipopolysaccharides induced DNA damage in astrocytes: Involvement of nitric oxide and mitochondria

(2015) Sonam Gupta et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors

(2015) Lisa Klingelhoefer et al.   Nature Reviews Neurology

Striatal Astrocytes Act as a Reservoir for L-DOPA

(2014) Masato Asanuma et al.   PLoS One

Pramipexole in patients with early Parkinson's disease (PROUD): a randomised delayed-start trial

(2013) Anthony HV Schapira et al.   LANCET NEUROLOGY

Targeting 5-HT1A receptors in astrocytes to protect dopaminergic neurons in parkinsonian models

(2013) Ikuko Miyazaki et al.   NEUROBIOLOGY OF DISEASE

Health Promoting Effects of Brassica-Derived Phytochemicals: From Chemopreventive and Anti-Inflammatory Activities to Epigenetic Regulation

(2013) Anika Eva Wagner et al.   Oxidative Medicine and Cellular Longevity

Promises of novel multi-target neuroprotective and neurorestorative drugs for Parkinson's disease

(2013) Moussa B.H. Youdim et al.   PARKINSONISM & RELATED DISORDERS

Zonisamide up-regulated the mRNAs encoding astrocytic anti-oxidative and neurotrophic factors

(2012) ME Choudhury et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model

(2012) L. Gan et al.   JOURNAL OF NEUROSCIENCE

Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

(2012) Wei Shao et al.   NATURE

L-theanine Administration Results in Neuroprotection and Prevents Glutamate Receptor Agonist-Mediated Injury in the Rat Model of Cerebral Ischemia-Reperfusion

(2012) Mavdzhuda Zukhurova et al.   PHYTOTHERAPY RESEARCH

Ammonia increases nitric oxide, free Zn2+, and metallothionein mRNA expression in cultured rat astrocytes

(2011) Carolin Kruczek et al.   BIOLOGICAL CHEMISTRY

Polyphenols activate Nrf2 in astrocytes via H2O2, semiquinones, and quinones

(2011) Hilla Erlank et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of the System x−C cystine/glutamate exchanger by intracellular glutathione levels in rat astrocyte primary cultures

(2011) Todd Michael Seib et al.   GLIA

Up-regulation of metallothionein gene expression in Parkinsonian astrocytes

(2011) Gregory J. Michael et al.   NEUROGENETICS

CNS delivery of l-dopa by a new hybrid glutathione–methionine peptidomimetic prodrug

(2010) Francesco Pinnen et al.   AMINO ACIDS

N-acetylcysteine prevents loss of dopaminergic neurons in theEAAC1−/−mouse

(2010) Ari E. Berman et al.   ANNALS OF NEUROLOGY

Dopaminergic neurons of system xc−-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity

(2010) Ann Massie et al.   FASEB JOURNAL

Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity

(2010) Ikuko Miyazaki et al.   GLIA

Neuroprotective Herbs and Foods from Different Traditional Medicines and Diets

(2010) Marcello Iriti et al.   MOLECULES

Liposomal-Glutathione Provides Maintenance of Intracellular Glutathione and Neuroprotection in Mesencephalic Neuronal Cells

(2010) Gail D. Zeevalk et al.   NEUROCHEMICAL RESEARCH

Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage

(2010) Petra Bergström et al.   NEUROPHARMACOLOGY

Different Susceptibility to the Parkinson's Toxin MPTP in Mice Lacking the Redox Master Regulator Nrf2 or Its Target Gene Heme Oxygenase-1

(2010) Nadia G. Innamorato et al.   PLoS One

Neuroprotective effects of zonisamide target astrocyte

(2009) Masato Asanuma et al.   ANNALS OF NEUROLOGY

Levetiracetam enhances endogenous antioxidant in the hippocampus of rats: In vivo evaluation by brain microdialysis combined with ESR spectroscopy

(2009) Yuto Ueda et al.   BRAIN RESEARCH

The Nrf2–ARE cytoprotective pathway in astrocytes

(2009) Marcelo R. Vargas et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson's disease

(2009) Robert A. Hauser et al.   MOVEMENT DISORDERS

A timeline for Parkinson's disease

(2009) Christopher H. Hawkes et al.   PARKINSONISM & RELATED DISORDERS

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

(2009) Pei-Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Theanine, γ-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats

(2008) T. Yamada et al.   AMINO ACIDS

Effects of Theanine, a Unique Amino Acid in Tea Leaves, on Memory in a Rat Behavioral Test

(2008) Takashi YAMADA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Design, Synthesis and Biological Evaluation of Glutathione Peptidomimetics as Components of Anti-Parkinson Prodrugs

(2008) Swati S. More et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glial Dysfunction in Parkin Null Mice: Effects of Aging

(2008) R. M. Solano et al.   JOURNAL OF NEUROSCIENCE

Approaches to Prevent Dopamine Quinone-Induced Neurotoxicity

(2008) Ikuko Miyazaki et al.   NEUROCHEMICAL RESEARCH

Pramipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity

(2008) Keiko Imamura et al.   NEUROSCIENCE LETTERS

Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: Novel cytoprotective mechanism against oxidative damage

(2008) Ju Hee Lim et al.   PHARMACOLOGICAL RESEARCH